ZFIN ID: ZDB-PERS-150722-2
Chiavacci, Elena
Email: elena.chiavacci@kcl.ac.uk
URL: https://www.icgeb.org/group-membersMolmed.html
Affiliation:
Address: School of Cardiovascular Medicine & Sciences Department Of Cardiology King’s College London James Black Centre 125 Coldharbour Lane London
Country: United Kingdom
Phone:
Fax:
ORCID ID: 0000-0003-3924-3635


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
Kirchgeorg, L., Felker, A., van Oostrom, M., Chiavacci, E., Mosimann, C. (2018) Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 247(10):1146-1159
Guzzolino, E., Chiavacci, E., Ahuja, N., Mariani, L., Evangelista, M., Ippolito, C., Rizzo, M., Garrity, D., Cremisi, F., Pitto, L. (2018) Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish. Frontiers in cell and developmental biology. 6:58
D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
Lindsay, H., Burger, A., Biyong, B., Felker, A., Hess, C., Zaugg, J., Chiavacci, E., Anders, C., Jinek, M., Mosimann, C., Robinson, M. D. (2016) CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat. Biotechnol.. 34:701-702
Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
Chiavacci, E., D'Aurizio, R., Guzzolino, E., Russo, F., Baumgart, M., Groth, M., Mariani, L., D'Onofrio, M., Arisi, I., Pellegrini, M., Cellerino, A., Cremisi, F., Pitto, L. (2015) MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome. Scientific Reports. 5:18240
Chiavacci, E., Rizzo, M., Pitto, L., Patella, F., Evangelista, M., Mariani, L., Rainaldi, G. (2015) The zebrafish/tumor xenograft angiogenesis assay as a tool for screening anti-angiogenic miRNAs. Cytotechnology. 67(6):969-75
Agostini, S., Chiavacci, E., Matteucci, M., Torelli, M., Pitto, L., Lionetti, V. (2015) Barley beta-glucan promotes MnSOD expression and enhances angiogenesis under oxidative microenvironment. Journal of Cellular and Molecular Medicine. 19(1):227-38
Chiavacci, E., Cremisi, F., Guzzolino, E., Cellerino, A., Baumgart, M., D'aurizio, R., Pitto, L. (2014) miR-19a replacement rescues cardiac and fin defects in zebrafish model of Holt-Oram Syndrome. Cardiovascular research. 103 Suppl 1:S99
Patella, F., Leucci, E., Evangelista, M., Parker, B., Wen, J., Mercatanti, A., Rizzo, M., Chiavacci, E., Lund, A.H., Rainaldi, G. (2013) MiR-492 impairs the angiogenic potential of endothelial cells. Journal of Cellular and Molecular Medicine. 17(8):1006-1015
Chiavacci, E., Rizzo, M., Patella, F., Evangeslista, M., Mariani, L., Rainaldi, G., Pitto, L. (2013) miR-492 inhibits the angiogenesis in zebrafish (Danio rerio) model. European Heart Journal. 34:1055
Chiavacci, E., Dolfi, L., Verduci, L., Meghini, F., Gestri, G., Evangelista, A.M., Wilson, S.W., Cremisi, F., and Pitto, L. (2012) MicroRNA 218 Mediates the Effects of Tbx5a Over-Expression on Zebrafish Heart Development. PLoS One. 7(11):e50536

NON-ZEBRAFISH PUBLICATIONS
Gambacciani C., Kusmic C., Chiavacci E., Meghini F., Rizzo M., Mariani L., Pitto L. (2014) miR-29a and miR-30c negatively regulate DNMT 3a in cardiac ischemic tissues: implications for cardiac remodelling. microRNA Diagnostics and Therapeutics 1(1): 2084-6843.