ZFIN Person: Zimmerman, Mark

ZFIN ID: ZDB-PERS-140722-14

Zimmerman, Mark

Email:	MarkW_Zimmerman@DFCI.HARVARD.EDU
URL:
Affiliation:	A. Thomas Look Lab
Address:
Country:	United States
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Weichert-Leahey, N., Shi, H., Tao, T., Oldridge, D.A., Durbin, A.D., Abraham, B.J., Zimmerman, M.W., Zhu, S., Wood, A.C., Reyon, D., Joung, J.K., Young, R.A., Diskin, S.J., Maris, J.M., Look, A.T. (2023) Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. The Journal of Clinical Investigation. 133(10):

Jing, C.B., Prutsch, N., He, S., Zimmerman, M.W., Landesman, Y., Look, A.T. (2023) Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors. British journal of haematology. 201(3):489-501

Oppel, F., Shao, S., Gendreizig, S., Zimmerman, M.W., Schürmann, M., Viyof Ful, F., Goon, P., Chi, S.N., Aster, J.C., Sudhoff, H., Look, A.T. (2022) p53 pathway inactivation drives SMARCB1-deficient p53-wildtype epithelioid sarcoma onset indicating therapeutic vulnerability through MDM2 inhibition. Molecular cancer therapeutics. 21(11):1689-1700

Shi, H., Tao, T., Abraham, B.J., Durbin, A.D., Zimmerman, M.W., Kadoch, C., Look, A.T. (2020) ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Science advances. 6:eaaz3440

Tao, T., Shi, H., Mariani, L., Abraham, B.J., Durbin, A.D., Zimmerman, M.W., Powers, J.T., Missios, P., Ross, K.N., Perez-Atayde, A.R., Bulyk, M.L., Young, R.A., Daley, G.Q., Look, A.T. (2020) LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Proceedings of the National Academy of Sciences of the United States of America. 117(28):16516-16526

Oppel, F., Tao, T., Shi, H., Ross, K.N., Zimmerman, M.W., He, S., Tong, G., Aster, J.C., Look, A.T. (2019) Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies. PLoS Genetics. 15:e1008039

Mansour, M.R., He, S., Li, Z., Lobbardi, R., Abraham, B.J., Hug, C., Rahman, S., Leon, T.E., Kuang, Y.Y., Zimmerman, M.W., Blonquist, T., Gjini, E., Gutierrez, A., Tang, Q., Garcia-Perez, L., Pike-Overzet, K., Anders, L., Berezovskaya, A., Zhou, Y., Zon, L.I., Neuberg, D., Fielding, A.K., Staal, F.J.T., Langenau, D.M., Sanda, T., Young, R.A., Look, A.T. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 215(7):1929-1945

Zimmerman, M.W., Liu, Y., He, S., Durbin, A.D., Abraham, B.J., Easton, J., Shao, Y., Xu, B., Zhu, S., Zhang, X., Li, Z., Weichert-Leahey, N., Young, R.A., Zhang, J., Look, A.T. (2018) MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer discovery. 8:320-335

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A.C., Oldridge, D., Ung, C.Y., van Ree, J.H., Khan, A., Salazar, B.M., Lummertz da Rocha, E., Zimmerman, M.W., Guo, F., Cao, H., Hou, X., Weroha, S.J., Perez-Atayde, A.R., Neuberg, D.S., Meves, A., McNiven, M.A., van Deursen, J.M., Li, H., Maris, J.M., Look, A.T. (2017) LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 32(3):310-323.e5

He, S., Mansour, M.R., Zimmerman, M.W., Ki, D.H., Layden, H.M., Akahane, K., Gjini, E., de Groh, E.D., Perez-Atayde, A.R., Zhu, S., Epstein, J.A., Look, A.T. (2016) Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. eLIFE. 5

Morrison, M.A., Zimmerman, M.W., Look, A.T., Stewart, R.A. (2016) Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish. Methods in cell biology. 134:97-138

NON-ZEBRAFISH PUBLICATIONS