ZFIN ID: ZDB-PERS-131003-6
Pei, Desheng
Email: peids@cqmu.edu.cn
URL: http://english.cigit.cas.cn/department/ttgioee/rceh/201403/t20140326_118503.html
Affiliation: Pei Lab, Research Center for Environment and Health (RCEH)
Address: Chongqing Medical University, Chinese Academy of Sciences 61 Daxuecheng Middle Road, Shapingba District, Chongqing 401331,China
Country: China
Phone: +862365935812
Fax: +862365935000
ORCID ID: 0000-0001-6408-9575

Our research interests mainly focus on studying toxicological effects, mechanisms and ecological risk assessment of classic environmental pollutants by using zebrafish model. We are endeavoring to develop the aquatic real-time biological monitoring technologies, and explore the pathogenic mechanisms or carcinogenesis. Our final goal is to provide the theoretical bases and technical support for environmental protection and the potential therapies of the related human diseases.

Research directions:
1.Developing the real-time biological monitoring of environmental pollutants.
2.Evaluating the toxicity and hazard of environmental pollutants.
3.Optimizing biological engineering species to sensitize environmental pollutants.
4.Elucidating DNA damage mechanisms of potentially carcinogenic pollutants.

Biography can be seen from Linkedin:

Jia, P.P., Liu, X.R., Wu, M.F., Li, Y., Zhang, L.C., Pei, D.S. (2024) Generation, Maintenance, and Identification of Germ-Free Zebrafish Models from Larvae to Juvenile Stages. Journal of visualized experiments : JoVE. (206):
Jia, P.P., Li, Y., Zhang, L.C., Wu, M.F., Li, T.Y., Pei, D.S. (2024) Metabolome evidence of CKDu risks after chronic exposure to simulated Sri Lanka drinking water in zebrafish. Ecotoxicology and environmental safety. 273:116149116149
Yang, G., Gou, D., Bu, L.K., Wei, X.Y., Hu, H., Huo, W.B., Sultan, M., Pei, D.S. (2024) Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health. Toxics. 12(2):
Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
Liu, Y., Huo, W.B., Deng, J.Y., Tang, Q.P., Wang, J.X., Liao, Y.L., Gou, D., Pei, D.S. (2023) Neurotoxicity and the potential molecular mechanisms of mono-2-ethylhexyl phthalic acid (MEHP) in zebrafish. Ecotoxicology and environmental safety. 265:115516115516
Wei, X.Y., Jia, P.P., Hu, H., Liu, L., Li, T.Y., Li, Y.Z., Pei, D.S. (2023) Multi-omics reveal mechanisms underlying chronic kidney disease of unknown etiology (CKDu) pathogenesis using zebrafish. Environmental pollution (Barking, Essex : 1987). 337:122524
Bu, L.K., Jia, P.P., Li, W.G., Li, Y.Z., Li, T.Y., Pei, D.S. (2023) Probiotics mitigate kidney damage after exposure to Sri Lanka's local groundwater from chronic kidney disease with uncertain etiology (CKDu) prevalent area in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 262:106671106671
Huo, W.B., Jia, P.P., Li, W.G., Xie, X.Y., Yang, G., Pei, D.S. (2023) Sulfonamides (SAs) exposure causes neurobehavioral toxicity at environmentally relevant concentrations (ERCs) in early development of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 261:106614106614
Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
Yang, Y.F., Li, W.G., Wen, P.P., Jia, P.P., Li, Y.Z., Li, T.Y., Pei, D.S. (2022) Exposure to Sri Lanka's local groundwater in a CKDu prevalent area causes kidney damage in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 251:106276
Deng, S., Zhang, E., Wang, Y., Zhao, Y., Yang, Z., Zheng, B., Mu, X., Deng, X., Shen, H., Rong, H., Pei, D. (2022) In vivo toxicity assessment of four types of graphene quantum dots (GQDs) using mRNA sequencing. Toxicology letters. 363:55-66
Hamid, N., Junaid, M., Manzoor, R., Duan, J.J., Lv, M., Xu, N., Pei, D.S. (2021) Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 242:106040
Jia, P.P., Junaid, M., Xin, G.Y., Wang, Y., Ma, Y.B., Pei, D.S. (2021) Disruption of Intestinal Homeostasis Through Altered Responses of the Microbial Community, Energy Metabolites, and Immune System in Zebrafish After Chronic Exposure to DEHP. Frontiers in microbiology. 12:729530
Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
Ma, Y.B., Manzoor, R., Jia, P.P., Bian, W.P., Hamid, N., Xie, Z.Y., Pei, D.S. (2021) Transcriptome and in silico approaches provide new insights into the mechanism of male reproductive toxicity induced by chronic exposure to DEHP. Environmental pollution (Barking, Essex : 1987). 289:117944
Jia, P.P., Junaid, M., Wen, P.P., Yang, Y.F., Li, W.G., Yang, X.G., Pei, D.S. (2021) Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish. Environmental pollution (Barking, Essex : 1987). 279:116925
Hamid, N., Junaid, M., Manzoor, R., Jia, P.P., Pei, D.S. (2020) Prioritizing phthalate esters (PAEs) using experimental in vitro/vivo toxicity assays and computational in silico approaches. Journal of hazardous materials. 398:122851
Pu, S.Y., Hamid, N., Ren, Y.W., Pei, D.S. (2019) Effects of phthalate acid esters on zebrafish larvae: Development and skeletal morphogenesis. Chemosphere. 246:125808
Hamid, N., Junaid, M., Pei, D.S. (2019) Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China. Journal of hazardous materials. 382:121106
Junaid, M., Wang, Y., Hamid, N., Deng, S., Li, W.G., Pei, D.S. (2019) Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach. Journal of hazardous materials. 380:120828
Pei, D.S., Jia, P.P., Luo, J.J., Liu, W., Strauss, P.R. (2019) AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death & Disease. 10:348
Bian, W.P., Chen, Y., Luo, J., Wang, C., Xie, S., Pei, D. (2019) A knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS synthetic biology. 8(4):621-632
Deng, S., Fu, A., Junaid, M., Wang, Y., Yin, Q., Fu, C., Liu, L., Su, D.S., Bian, W.P., Pei, D.S. (2019) Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish. Biomaterials. 206:61-72
Dong, W., Wang, F., Fang, M., Wu, J., Wang, S., Li, M., Yang, J., Chernick, M., Hinton, D.E., Pei, D.S., Chen, H., Zheng, N., Mu, J., Xie, L., Dong, W. (2019) Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China. Ecotoxicology and environmental safety. 173:339-346
Jia, P.P., Sun, T., Junaid, M., Yang, L., Ma, Y.B., Cui, Z.S., Wei, D.P., Shi, H.F., Pei, D.S. (2019) Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo. Environmental pollution (Barking, Essex : 1987). 247:595-606
Junaid, M., Jia, P.P., Tang, Y.M., Xiong, W.X., Huang, H.Y., Strauss, P.R., Li, W.G., Pei, D.S. (2018) Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environmental pollution (Barking, Essex : 1987). 242(Pt B):1939-1949
Deng, S., Jia, P.P., Zhang, J.H., Junaid, M., Niu, A., Ma, Y.B., Fu, A., Pei, D.S. (2018) Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of hazardous materials. 357:146-158
Luo, J.J., Bian, W.P., Liu, Y., Huang, H.Y., Yin, Q., Yang, X.J., Pei, D.S. (2018) CRISPR/Cas9-based genome engineering of zebrafish using a seamless integration strategy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9):5132-5142
Luo, J.J., Su, D.S., Xie, S.L., Liu, Y., Liu, P., Yang, X.J., Pei, D.S. (2018) Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5):2814-2826
Wang, C., Chen, Y.L., Bian, W.P., Xie, S.L., Qi, G.L., Liu, L., Strauss, P.R., Zou, J.X., Pei, D.S. (2017) Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish & shellfish immunology. 72:572-580
Ma, Y.B., Jia, P.P., Junaid, M., Yang, L., Lu, C.J., Pei, D.S. (2017) Reproductive effects linked to DNA methylation in male zebrafish chronically exposed to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate. Environmental pollution (Barking, Essex : 1987). 237:1050-1061
Xie, S.L., Junaid, M., Bian, W.P., Luo, J.J., Syed, J.H., Wang, C., Xiong, W.X., Ma, Y.B., Niu, A., Yang, X.J., Zou, J.X., Pei, D.S. (2017) Generation and application of a novel transgenic zebrafish line Tg(cyp1a:mCherry) as an in vivo assay to sensitively monitor PAHs and TCDD in the environment. Journal of hazardous materials. 344:723-732
Lu, C.J., Jiang, X.F., Junaid, M., Ma, Y.B., Jia, P.P., Wang, H.B., Pei, D.S. (2017) Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Chemosphere. 184:795-805
Zhang, J.H., Sun, T., Niu, A., Tang, Y.M., Deng, S., Luo, W., Xu, Q., Wei, D., Pei, D.S. (2017) Perturbation effect of reduced graphene oxide quantum dots (rGOQDs) on aryl hydrocarbon receptor (AhR) pathway in zebrafish. Biomaterials. 133:49-59
Tang, Y.M., Junaid, M., Niu, A., Deng, S., Pei, D.S. (2017) Diverse toxicological risks of PAHs in surface water with an impounding level of 175m in the Three Gorges Reservoir Area, China. The Science of the total environment. 580:1085-1096
Li, J., Niu, A., Lu, C.J., Zhang, J.H., Junaid, M., Strauss, P.R., Xiao, P., Wang, X., Ren, Y.W., Pei, D.S. (2017) A novel forward osmosis system in landfill leachate treatment for removing polycyclic aromatic hydrocarbons and for direct fertigation. Chemosphere. 168:112-121
Zhang, J.H., Niu, A., Li, J., Fu, J.W., Xu, Q., Pei, D.S. (2016) In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish. Scientific Reports. 6:37860
Xie, S.L., Bian, W.P., Wang, C., Junaid, M., Zou, J.X., Pei, D.S. (2016) A novel technique based on in vitro oocyte injection to improve CRISPR/Cas9 gene editing in zebrafish. Scientific Reports. 6:34555
Niu, A., Ren, Y.W., Yang, L., Xie, S.L., Jia, P.P., Zhang, J.H., Wang, X., Li, J., Pei, D.S. (2016) Toxicological characterization of a novel wastewater treatment process using EDTA-Na2Zn as draw solution (DS) for the efficient treatment of MBR-treated landfill leachate. Chemosphere. 155:100-108
Jia, P.P., Ma, Y.B., Lu, C.J., Mirza, Z., Zhang, W., Jia, Y.F., Li, W.G., Pei, D.S. (2016) The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS One. 11:e0155762
Dai, Y.J., Jia, Y.F., Chen, N., Bian, W.P., Li, Q.K., Ma, Y.B., Chen, Y.L., and Pei, D.S. (2014) Zebrafish as a model system to study toxicology. Environmental toxicology and chemistry. 33(1):11-17
Pei, D., Luther, W., Wang, W., Paw, B.H., Stewart, R.A., and George, R.E. (2013) Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genetics. 9(6):e1003533
Pei, D.S., and Strauss, P.R. (2013) Zebrafish as a model system to study DNA damage and repair. Mutation research. 743-744:151-9
Chen, Y., Wu, B., Xu, L., Li, H., Xia, J., Yin, W., Li, Z., Li, S., Lin, S., Shu, X., and Pei, D. (2012) A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Research. 22(2):333-345
Pei, D.S., Yang, X.J., Liu, W., Guikema, J.E., Schrader, C.E., and Strauss, P.R. (2011) A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic acids research. 39(8):3156-3165
Chen, C.H., Sun, Y.H., Pei, D.S., and Zhu, Z.Y. (2009) Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(11):2850-2859
Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2009) Identification of a novel gene K23 over-expressed in fish cross-subfamily cloned embryos. Molecular biology reports. 36(6):1375-1380
Liu, J., Sun, Y.H., Wang, Y.W., Wang, N., Pei, D.S., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology. 70(9):1525-1535
Pei, D.S., Sun, Y.H., Long, Y., and Zhu, Z.Y. (2008) Inhibition of no tail (ntl) gene expression in zebrafish by external guide sequence (EGS) technique. Molecular biology reports. 35(2):139-143
Pei, D.S., Sun, Y.H., Chen, C.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Developmental Biology. 8:29
Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2008) Construction of cytoplasmic molecular markers distinguishing Danio rerio from Gobiocypris rarus at high identity domains based on MP-PCR strategy and Sybr Green I detection. Molecular biology reports. 35(1):45-50
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology. 68(9):1282-1291
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Analytical biochemistry. 363(2):291-293

1. Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei DS, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L*, George RE*. The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma. Cancer Cell. 22(1):117-30,2012.

2. Zhong S, Wang YP, Pei DS, Luo DJ, Liao LJ, Zhu ZY*. A one-year investigation of the relationship between serum GH levels and the growth of F4 transgenic and non-transgenic common carp Cyprinus carpio. J Fish Biol. 75 (5): 1092-1100, 2009

3. Pei DS, Sun YH, Chen SP, Wang YP, Zhu ZY*. Cloning and characterization of cytochrome c oxidase subunit I (COXI) in Gobiocypris rarus. Mitochondr DNA / DNA Seq. 18(1):1-8, 2007.