ZFIN Person: Cancela, Leonor

ZFIN ID: ZDB-PERS-130911-1

ZFIN ID: ZDB-PERS-130911-1

Cancela, Leonor

Email:	lcancela@ualg.pt
URL:
Affiliation:
Address:	University of Algarve, Dept of Biomedical Sciences and Medicine / CCMAR Campus de Gambelas 8005-139 Faro Portugal
Country:
Phone:	(+351)289800971
Fax:	(+351)289800076
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310

Adrião, A., Mariano, S., Mariano, J., Gavaia, P.J., Cancela, M.L., Vitorino, M., Conceição, N. (2023) mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour. Biomolecules. 13(5):

Poudel, S., Martins, G., Cancela, M.L., Gavaia, P.J. (2022) Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation. International Journal of Molecular Sciences. 23(23):

Poudel, S., Martins, G., Cancela, M.L., Gavaia, P.J. (2022) Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish. Nutrients. 14(23):

Silva, I.A.L., Varela, D., Cancela, M.L., Conceição, N. (2022) Zebrafish optineurin: genomic organization and transcription regulation. Genome. 65(10):513-523

Varela, T., Varela, D., Martins, G., Conceição, N., Cancela, M.L. (2022) Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 12:9325

Tarasco, M., Gavaia, P.J., Bensimon-Brito, A., Cordelières, F.P., Santos, T., Martins, G., de Castro, D.T., Silva, N., Cabrita, E., Bebianno, M.J., Stainier, D.Y.R., Cancela, M.L., Laizé, V. (2022) Effects of pristine or contaminated polyethylene microplastics on zebrafish development. Chemosphere. 303(Pt 3):135198

Tarasco, M., Gavaia, P.J., Bensimon-Brito, A., Cardeira-da-Silva, J., Ramkumar, S., Cordelières, F.P., Günther, S., Bebianno, M.J., Stainier, D.Y.R., Cancela, M.L., Laizé, V. (2021) New insights into benzo[⍺]pyrene osteotoxicity in zebrafish. Ecotoxicology and environmental safety. 226:112838

Roberto, V.P., Surget, G., Le Lann, K., Mira, S., Tarasco, M., Guérard, F., Poupart, N., Laizé, V., Stiger-Pouvreau, V., Cancela, M.L. (2021) Antioxidant, Mineralogenic and Osteogenic Activities of Spartina alterniflora and Salicornia fragilis Extracts Rich in Polyphenols. Frontiers in nutrition. 8:719438

Tarasco, M., Cordelières, F.P., Cancela, M.L., Laizé, V. (2020) ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures. Bone. 138:115480

Tarasco, M., Martins, G., Gavaia, P.J., Bebianno, M.J., Cancela, M.L., Laizé, V. (2020) ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts. Zebrafish. 17:18-26

Santos, J.M.A., Mendes-Silva, L., Afonso, V., Martins, G., Machado, R.S.R., Lopes, J.A., Cancela, L., Futschik, M.E., Sachinidis, A., Gavaia, P., Bragança, J. (2019) Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants. Cell Death & Disease. 10:582

Granadeiro, L., Dirks, R.P., Ortiz-Delgado, J.B., Gavaia, P.J., Sarasquete, C., Laizé, V., Cancela, M.L., Fernández, I. (2019) Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - From molecular mechanisms to environmental concerns. Ecotoxicology and environmental safety. 181:559-571

Carson, M.A., Nelson, J., Cancela, M.L., Laizé, V., Gavaia, P.J., Rae, M., Heesch, S., Verzin, E., Gilmore, B.F., Clarke, S.A. (2019) Correction: Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. PLoS One. 14:e0211395

Carson, M.A., Nelson, J., Cancela, M.L., Laizé, V., Gavaia, P.J., Rae, M., Heesch, S., Verzin, E., Gilmore, B.F., Clarke, S.A. (2018) Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. PLoS One. 13:e0207303

Laizé, V., Gavaia, P.J., Tarasco, M., Viegas, M.N., Caria, J., Luis, N., Cancela, M.L. (2018) Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and environmental safety. 161:721-728

Carson, M.A., Nelson, J., Cancela, M.L., Laizé, V., Gavaia, P.J., Rae, M., Heesch, S., Verzin, E., Maggs, C., Gilmore, B.F., Clarke, S.A. (2018) Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports. 8:7725

Vitorino, M., Cunha, N., Conceição, N., Cancela, M.L. (2018) Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome. Molecular biology reports. 45(4):445-451

Vitorino, M., Conceicao, N., and Cancela, M. L. (2018) Zebrafish (Danio rerio, Hamilton‐Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology.

Roberto, V.P., Gavaia, P., Nunes, M.J., Rodrigues, E., Cancela, M.L., Tiago, D.M. (2018) Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 8:3704

Fernández, I., Gavaia, P.J., Laizé, V., Cancela, M.L. (2017) Fish as a model to assess chemical toxicity in bone. Aquatic toxicology (Amsterdam, Netherlands). 194:208-226

Carvalho, F.R., Fernandes, A.R., Cancela, M.L., Gavaia, P.J. (2017) Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 25(3):432-442

Cardeira, J., Gavaia, P.J., Fernández, I., Cengiz, I.F., Moreira-Silva, J., Oliveira, J.M., Reis, R.L., Cancela, M.L., Laizé, V. (2016) Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin. Scientific Reports. 6:39191

Divisato, G., Formicola, D., Esposito, T., Merlotti, D., Pazzaglia, L., Del Fattore, A., Siris, E., Orcel, P., Brown, J.P., Nuti, R., Strazzullo, P., Benassi, M.S., Cancela, M.L., Michou, L., Rendina, D., Gennari, L., Gianfrancesco, F. (2016) ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. American journal of human genetics. 98:275-86

Adrião, A., Conceição, N., Cancela, M.L. (2016) MEF2C orthologues from zebrafish: evolution, expression and promoter regulation. Archives of biochemistry and biophysics. 591:43-56

Marques, C.L., Fernández, I., Viegas, M.N., Cox, C.J., Martel, P., Rosa, J., Cancela, M.L., Laizé, V. (2016) Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives. Cellular and molecular life sciences : CMLS. 73(4):841-57

Bensimon-Brito, A., Cardeira, J., Dionísio, G., Huysseune, A., Cancela, M.L., Witten, P.E. (2016) Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration. BMC Developmental Biology. 16:2

Marques, C.L., Cancela, M.L., Laizé, V. (2016) Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Gene. 576:229-36

Fazenda, C., Conceição, N., Cancela, M.L. (2015) Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Gene. 572(1):57-62

Roberto, V.P., Tiago, D.M., Gautvik, K., Cancela, M.L. (2015) Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 566(1):54-62

Fernández, I., Vijayakumar, P., Marques, C., Cancela, M.L., Gavaia, P.J., Laizé, V. (2015) Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish physiology and biochemistry. 41(3):745-59

Simões, B., Conceição, N., Matias, A.C., Bragança, J., Kelsh, R.N., Cancela, M.L. (2015) Molecular characterization of cbfβ gene and identification of new transcription variants: Implications for function. Archives of biochemistry and biophysics. 567:1-12

Fernández, I., Santos, A., Cancela, M.L., Laizé, V., Gavaia, P.J. (2014) Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental pollution (Barking, Essex : 1987). 194C:86-95

Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688

Simões, B., Conceição, N., Kelsh, R. N., Cancela, M. L. (2014) Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: implications for function. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):661-670

Conceição, N., Cox, C. J., Simões, B., Viegas, M., Cancela, M. L. (2010) Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):245-250

Bensimon-Brito, A., Cancela, M. L., Huysseune, A., Witten, P. E. (2010) The zebrafish (Danio rerio) caudal complex – a model to study vertebral body fusion. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):235-238

Robles, V., and Cancela, M.L. (2007) Lipid‐based transfection as a method for gene delivery in zebrafish (Danio rerio) embryos. Aquaculture research. 38(12)

NON-ZEBRAFISH PUBLICATIONS