ZFIN Person: Wythe, Joshua

ZFIN ID: ZDB-PERS-130725-1

ZFIN ID: ZDB-PERS-130725-1

Wythe, Joshua

Email:	joshwythe@gmail.com
URL:	http://www.wythelab.com
Affiliation:	Wythe Lab
Address:	Baylor College of Medicine One Baylor Plaza Rm 413B / Mail Stop BCM335 Houston, Texas 77030
Country:
Phone:	713-798-3657
Fax:
ORCID ID:	0000-0002-3225-2937

BIOGRAPHY AND RESEARCH INTERESTS

2014-
Assistant Professor
Cardiovascular Research Institute
Baylor College of Medicine

2012-2014
Staff Scientist
UCSF
Gladstone Institute of Cardiovascular Disease

2011-2012
Research Scientist
UCSF
Gladstone Institute of Cardiovascular Disease
Benoit Bruneau Lab

Postdoc
2008-2011
UCSF
Gladstone Insitute of Cardiovascular Disease
Benoit Bruneau Lab

PhD
2007
University of Utah
Oncological Sciences
Dean Y. Li Lab

M.S., M.A.
2001
Miami University
Botany / History
Makaroff and Kiss Labs

PUBLICATIONS

Fish, J.E., Flores-Suarez, C.P., Boudreau, E., Herman, A.M., Gutierrez, M.C., Gustafson, D., DiStefano, P.V., Cui, M., Chen, Z., Berman De Ruiz, K., Schexnayder, T.S., Ward, C.S., Radovanovic, I., Wythe, J.D. (2020) Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling. Circulation research. 127(6):727-743

Cantu Gutierrez, A., Cantu Gutierrez, M., Rhyner, A.M., Ruiz, O.E., Eisenhoffer, G.T., Wythe, J.D. (2019) FishNET: An automated relational database for zebrafish colony management. PLoS Biology. 17:e3000343

Wang, K., Zhao, S., Liu, B., Zhang, Q., Li, Y., Liu, J., Shen, Y., Ding, X., Lin, J., Wu, Y., Yan, Z., Chen, J., Li, X., Song, X., Niu, Y., Liu, J., Chen, W., Ming, Y., Du, R., Chen, C., Long, B., Zhang, Y., Tong, X., Zhang, S., Posey, J.E., Zhang, B., Wu, Z., Wythe, J.D., Liu, P., Lupski, J.R., Yang, X., Wu, N. (2018) Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM). Journal of Medical Genetics. 55(10):675-684

Fish, J.E., Cantu Gutierrez, M., Dang, L.T., Khyzha, N., Chen, Z., Veitch, S., Cheng, H.S., Khor, M., Antounians, L., Njock, M.S., Boudreau, E., Herman, A.M., Rhyner, A.M., Ruiz, O.E., Eisenhoffer, G.T., Medina-Rivera, A., Wilson, M.D., Wythe, J.D. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development (Cambridge, England). 144:2428-2444

Fish, J.E., Wythe, J.D. (2015) The Molecular Regulation of Arteriovenous Specification and Maintenance. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(3):391-409

Wythe, J.D., Dang, L.T., Devine, W.P., Boudreau, E., Artap, S.T., He, D., Schachterle, W., Stainier, D.Y., Oettgen, P., Black, B.L., Bruneau, B.G., and Fish, J.E. (2013) ETS Factors Regulate Vegf-Dependent Arterial Specification. Developmental Cell. 26(1):45-58

Wythe, J.D., Jurynec, M.J., Urness, L.D., Jones, C.A., Sabeh, M.K., Werdich, A.A., Sato, M., Yost, H.J., Grunwald, D.J., MacRae, C.A., and Li, D.Y. (2011) Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Disease models & mechanisms. 4(5):607-21

Fish, J.E., Wythe, J.D., Xiao, T., Bruneau, B.G., Stainier, D.Y., Srivastava, D., and Woo, S. (2011) A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (Cambridge, England). 138(7):1409-1419

Fish, J.E., Santoro, M.M., Morton, S.U., Yu, S., Yeh, R.F., Wythe, J.D., Ivey, K.N., Bruneau, B.G., Stainier, D.Y., and Srivastava, D. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Developmental Cell. 15(2):272-284

Navankasattusas, S., Whitehead, K.J., Suli, A., Sorensen, L.K., Lim, A.H., Zhao, J., Park, K.W., Wythe, J.D., Thomas, K.R., Chien, C.B., and Li, D.Y. (2008) The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development (Cambridge, England). 135(4):659-667

Park, K.W., Urness, L.D., Senchuk, M.M., Colvin, C.J., Wythe, J.D., Chien, C.B., and Li, D.Y. (2005) Identification of new netrin family members in zebrafish: Developmental expression of netrin2 and netrin4. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(3):726-731

NON-ZEBRAFISH PUBLICATIONS
Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B (2015). Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun. PMID: 25597280

He L, Tian X, Zhang H, Wythe JD, Zhou B (2014). Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations. J Cell Mol Med. PMID: 25265869

Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG (2014).Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. PMID: 25296024

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol (7):1181-96. PMID: 21690310

Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY (2008) Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med (4):448-53. Erratum in: Nat Med. 2008 May;14(5):585. PMID: 18345009

Karnik SK, Wythe JD, Sorensen L, Brooke BS, Urness LD, Li DY (2003) Elastin induces myofibrillogenesis via a specific domain, VGVAPG. Matrix Biol. 22(5):409-25. PMID: 14614988

Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY (2003) A critical role for elastin signaling in vascular morphogenesis and disease. Development, 130(2):411-23. PMID: 12466207