ZFIN ID: ZDB-PERS-130212-3
Opitz, Robert
Email: r.opitz@excite.com
URL:
Affiliation: Costagliola Lab
Address:
Country: Belgium
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Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Haerlingen, B., Opitz, R., Vandernoot, I., Molinaro, A., Shankar, M.P., Gillotay, P., Trubiroha, A., Costagliola, S. (2023) Mesodermal FGF and BMP govern the sequential stages of zebrafish thyroid specification. Development (Cambridge, England). 150(10):
Narumi, S., Opitz, R., Nagasaki, K., Muroya, K., Asakura, Y., Adachi, M., Abe, K., Sugisawa, C., Kühnen, P., Ishii, T., Nöthen, M.M., Krude, H., Hasegawa, T. (2022) GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling. Human molecular genetics. 31(23):3967-3974
Barone, M., Müller, M., Chiha, S., Ren, J., Albat, D., Soicke, A., Dohmen, S., Klein, M., Bruns, J., van Dinther, M., Opitz, R., Lindemann, P., Beerbaum, M., Motzny, K., Roske, Y., Schmieder, P., Volkmer, R., Nazaré, M., Heinemann, U., Oschkinat, H., Ten Dijke, P., Schmalz, H.G., Kühne, R. (2020) Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 117(47):29684-29690
Vandernoot, I., Haerlingen, B., Gillotay, P., Trubiroha, A., Janssens, V., Opitz, R., Costagliola, S. (2020) Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects. Thyroid : official journal of the American Thyroid Association. 31(3):420-438
Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635
Haerlingen, B., Opitz, R., Vandernoot, I., Trubiroha, A., Gillotay, P., Giusti, N., Costagliola, S. (2019) Small Molecule Screening in Zebrafish Embryos Identifies Signaling Pathways Regulating Early Thyroid Development. Thyroid : official journal of the American Thyroid Association. 29(11):1683-1703
Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
Opitz, R., Hitz, M.P., Vandernoot, I., Trubiroha, A., Abu-Khudir, R., Samuels, M., Désilets, V., Costagliola, S., Andelfinger, G., Deladoëy, J. (2015) Functional Zebrafish Studies Based on Human Genotyping Point to Netrin-1 as a Link Between Aberrant Cardiovascular Development and Thyroid Dysgenesis. Endocrinology. 1(1):377-88
Opitz, R., Antonica, F., Costagliola, S. (2013) New Model Systems to Illuminate Thyroid Organogenesis. Part I: An Update on the Zebrafish Toolbox. European thyroid journal. 2:229-242
Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99

NON-ZEBRAFISH PUBLICATIONS