ZFIN Person: Leighton, Patricia

ZFIN ID: ZDB-PERS-130205-3

Leighton, Patricia

Email:	pleighto@ualberta.ca
URL:
Affiliation:	Allison Lab
Address:
Country:	Canada
Phone:
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ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Pollock, N.M., Leighton, P., Neil, G., Allison, W.T. (2021) Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein. Prion. 15:70-81

Özcan, G.G., Lim, S., Leighton, P., Allison, W.T., Rihel, J. (2020) Sleep is bi-directionally modified by amyloid beta oligomers. eLIFE. 9:

Kanyo, R., Leighton, P.L.A., Neil, G.J., Locskai, L.F., Allison, W.T. (2020) Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Experimental neurology. 328:113283

Leighton, P.L.A., Kanyo, R., Neil, G.J., Pollock, N.M., Allison, W.T. (2018) Prion gene paralogs are dispensable for early zebrafish development but have non-additive roles in seizure susceptibility. The Journal of biological chemistry. 293(32):12576-12592

Leighton, P.L.A., Nadolski, N.J., Morrill, A., Hamilton, T.J., Allison, W.T. (2018) An ancient conserved role for prion protein in learning and memory. Biology Open. 7(1)

Huc-Brandt, S., Hieu, N., Imberdis, T., Cubedo, N., Silhol, M., Leighton, P.L., Domaschke, T., Allison, W.T., Perrier, V., Rossel, M. (2014) Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development. PLoS One. 9:e113331

Pillay, L.M., Selland, L.G., Fleisch, V.C., Leighton, P.L., Cheng, C.S., Famulski, J.K., Ritzel, R.G., March, L.D., Wang, H., Allison, W.T., and Waskiewicz, A.J. (2013) Evaluating the Mutagenic Activity of Targeted Endonucleases Containing a Sharkey FokI Cleavage Domain Variant in Zebrafish. Zebrafish. 10(3):353-64

Fleisch, V.C., Leighton, P.L., Wang, H., Pillay, L.M., Ritzel, R.G., Bhinder, G., Roy, B., Tierney, K.B., Ali, D.W., Waskiewicz, A.J., and Allison, W.T. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of disease. 55:11-25

Kaiser, D.M., Acharya, M., Leighton, P.L., Wang, H., Daude, N., Wohlgemuth, S., Shi, B., and Allison, W.T. (2012) Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. PLoS One. 7(12):e51305

NON-ZEBRAFISH PUBLICATIONS