Person
Zolessi, Flavio
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Biography and Research Interest
Our general research interest is centered on understanding the mechanisms of neural differentiation, both in normal and pathological situations. In particular, the main focus is on understanding cell polarity transitions that occur through the different stages of neural development in vertebrates, from neurulation to neuronal differentiation, mostly using zebrafish and chick as experimental systems.
Non-Zebrafish Publications
Lupo G, Piper M, Zolessi FR (2021) Editorial: Context-dependent regulation of neurogenesis: common themes and unique features of the neurogenic process in different model systems. Front. Cell Dev. Biol. 9:678475. doi: 10.3389/fcell.2021.678475.
Zolessi FR, Berois N, Brauer MM, Castillo E (2021) Building the embryo of developmental biology in Uruguay. Intl J Devl Biol 65: 71 - 76. doi: 10.1387/ijdb.200141fz
Aparicio G, Arruti C, Zolessi FR (2018) MARCKS phosphorylation by PKC strongly impairs cell polarity in the chick neural plate. Genesis 56(4): e23104. doi: 10.1002/dvg.23104.
Lepanto P, Badano JL, Zolessi FR* (2016) Neuron’s little helper: the role of primary cilia in neurogenesis. Neurogenesis. 3:1, e1253363. Review. doi: 10.1080/23262133.2016.1253363.
Zolessi FR (2016) Vertebrate neurogenesis: cell polarity (v. 3). Encyclopedia of Life Sciences (Wiley). DOI: 10.1002/9780470015902.a0000826.pub3.
Tinoco L.W., Fraga J.L., AnoBom C.D., Zolessi F.R., Obal G., Toledo A., Pritsch O., Arruti C. (2014) Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. Biochim Biophys Acta 1844(4): 837-849.
Toledo A., Zolessi F.R., Arruti C. (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLOS ONE 8(4): e62863.
Ruiz-Perera L.M., Arruti C., Zolessi F.R. (2013) Early phosphorylation of MARCKS at Ser25 in migrating precursor cells and differentiating peripheral neurons. Neurosci. Lett. 544: 5-9.
Zolessi F.R., Arruti C. (2004) MARCKS in advanced stages of neural retina histogenesis. Dev. Neurosci. 26: 371-379.
Zolessi F.R., Durán R., Engström U., Cerveñansky C., Hellman U., Arruti C. (2004) Identification of the chicken MARCKS phosphorylation site specific for differentiating neurons as Ser 25 using a monoclonal antibody and mass spectrometry. J. Proteome Res. 3: 84-90.
Zolessi F.R., Arruti C. (2001) Sustained phosphorylation of MARCKS in differentiating neurogenic regions during chick embryo development. Brain Res. Dev. Brain Res. 130: 257-267.
Zolessi F.R., Arruti C. (2001) Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo. BMC Dev. Biol. 1: 7.
Zolessi F.R., Hellman U., Baz A., Arruti C. (1999) Characterization of MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) identified by a monoclonal antibody generated against chick embryo neural retina. Biochem. Biophys. Res. Commun. 257: 480-487.