Biography and Research Interest

BSc Nankai University; PhD University of Pennsylvania

Research interests:
Angiogenesis, vasculogenesis, liver organogenesis, anti-angiogenic proteins and therapeutics

Publications

Non-Zebrafish Publications

1. G. S. Marshall, R. P. Ricciardi, R. F. Rando, J. Puck, R. Ge, S. A. Plotkin and E. Gonczol, An Adenovirus Recombinant that Express the Human Cytomegalovirus Major Envelope Glycoprotein and Induces Neutralizing Antibodies. J. Infect. Dis. Vol.162, p1177-1181, 1990.


2. R. Ge, A. Kralli, R. Weinmann and R. P. Ricciardi, Down-regulation of the Major Histocompatibility Complex Class I Enhancer In Adenovirus-12-Transformed Cells Is Accompanied By An Increase In Factor Binding. J. Virology. Vol 66, No. 12. p6969-6978, 1992.


3. Kralli, R. Ge, U. Graeven, R. P. Ricciardi and R. Weinmann, Negative Regulation of the Major Histocompatibility Complex (MHC) Class I Enhancer In Ad12-Transformed Cells via a Retinoic Acid-Response Element. J. Virology. Vol 66, No.12. p6979-6988, 1992.

4. Mak,P, H. A. Fuernkranz, R. Ge and S. K. Karathanasis, Retinoid X Receptor Homodimers Function As Transcriptional Activators In Yeast. Gene, Vol 145, p129-133, 1994.


5. X. Liu, R. Ge, S. Westmoreland, A. J. Cooney, S. Y. Cai, M-J. Cai and R. P. Ricciardi, Involvement Of COUP-TF Like Proteins In Repressing Class I MHC Gene Expression In Adenovirus-12 Transformed Mouse Cells. Oncogene Vol 9, p2183-2190, 1994.


6. X. Ye, A. Kralli, R. Ge, R. P. Ricciardi and B. Knowles, Downregulation of MHC Class I Antigen in Insulinoma Cells Is Controlled by a Cis-element in Enhancer A region of H-2 Promoter. Oncogene Vol 9, p1195-1204, 1994.


7. R. Ge, X. Liu and R. P. Ricciardi, The Ad12-transformed cells contain trans repressors that can switch off class I MHC gene expression. Virology , Vol 203, p389-392, 1994.


8. R. Ge, M. Rhee, S. Malik and S. K. Karathanasis, Transcriptional Repression of ApoA1 Gene Expression in Liver Cells by ARP-1. J. Biol. Chem. Vol. 269,, No. 18, p13185-13192, 1994.


9. Liu, X, R. Ge, and R. P. Ricciardi, Evidence For The Involvement Of A Nuclear NF-ƒÛB Inhibitor In Global Down-Regulation Of The Major Histocompatibility Complex Class I Enhencer In Adenovirus Type 12-Transformed Cells. Mol. Cell. Biol. Vol.16, No.1: p398-404, 1996.


10. Lee, S. Y, Z. Yin, R. Ge and Y.M.Sin, Isolation and characterization of fish Aeromonas hydrophila adhesins important for in vitro epithelial cell invasion. J. Fish Dis. Vol 20, p169-175, 1997.


11. Fang HM, KC Ling, YL Tan, R Ge and YM Sin. In vitro inhibition of epithelial cell invasion by Aeromonas hydrophila and Vibrio species by fish Aeromonas hydrophila major adhesin. J. Fish Dis. Vol 21, p273-280, 1998.

12. Ge, R. Genetically Manipulated Animals And Their Use In Experimental Research. Ann. Acad. Med. Singapore, Vol 28, 560-564, 1999.

13. Gong, B and R. Ge. Using the SMARTTM cDNA System To Map the Transcription Initiation Site. BioTechniques Vol. 28, p846-852, 2000.

14. Fang, H., K. C. Ling, R. Ge and Y. M. Sin. Enhancement Of Protective Immunity In blue bourami, Trichogaster trichopterus (Pallas), against Aeromonas hydrophila and Vibro anguillarum by A. hydrophila Major Adhesin. J. Fish Dis. Vol. 23, p137-145, 2000.


15. Tan, D C-W., M. R. Kini., J. D. S. Seetharama, D. K-F Lim, L. Xin and R. Ge. A Small Peptide Derived From Flt-1 (VEGFR-1) Functions As An Angiogenic Inhibitor. FEBS Lett. Vol 494, p150-156, 2001.

16. Shim, W. S. N, M. Teh, P. Mack and R. Ge. Inhibition Of Angiopoietin-1 Expression In Tumor Cells By An Antisense RNA Approach Inhibited Xenograft Tumor Growth In Immunodeficient Mice. Int. J. Cancer, Vol 94, 6-15, 2001.

17. Zhang L, Ge R, Shim W, Sim EKW, El Oakley RM. Therapeutic Angiogenesis Using Angiogenic Factors For Ischemic Heart Disease. Med. Progress, Vol 29, 35-43, 2002.


18. Shim, W. S. N, M. Teh, A. Bapna, I, Kim, G-Y Koh, P. Mack and R. Ge. Angiopoietin-1 Promotes Tumor Angiogenesis and Tumor Vessel Plasticity of Human Cervical Cancer in Mice. Exp. Cell Res., Vol 279, 299-309, 2002.

19. Sim EK, Zhang L, Shim WS, Lim YL, Ge R. Therapeutic Angiogenesis for Coronary Artery Disease. J. Cardiac Surg. Vol 17, 350-354, 2002.

20. Ye L, Haider HKh, Jiang S, Ge R, Law PK, Sim EK. High efficiency transduction of human VEGF165 into human skeletal myoblasts: in vitro studies. Exp. Mol. Med. 35(5): 412-20, 2003.

21. Sun, F., B. D. F. Casse, J. A. Van Kan, R. Ge* and F. Watt. Geometric Control of fibroblasts Growth on Proton Beam Micromachined Scaffolds. *corresponding author. Tissue Eng., Vol. 10, 267-272, 2004. (IF: 3.7, Tier 1) (main-author)

22. Fang, H., R. Ge and Y. M. Sin. Cloning, Expression and Role in Protective Immunity of A Fish Aeromona hydrophila Major Adhesion. Fish Shellfish Immunol. 16:645-58. 2004. (IF: 2.7, Tier 2) (co-author)

23. Muhammad I. Niagara, Husnain Kh. Haider, Lei Ye, Valerie S. W. Koh, Yean T. Lim, Kian K. Poh, Ruowen Ge, and Eugene K. W. Sim. Autologous skeletal myoblasts transduced with a new adenoviral bicistronic vector for treatment of hind limb ischemia. J. Vas. Surg. 40: 774-85, 2004. (IF: 3.3, Tier 2) (co-author)

24. Husnain Kh Haider, Lei Ye, Shujia Jiang, Ruowen Ge, Peter K. Law, Terrance Chua, Phillip Wong and Eugene K. W. Sim. Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor. J. Mol. Med., 82: 539-49, 2004. (IF: 5.2, Tier 1) (co-author)

25. F. Zhang, F. Sun, J. A. Van Kan, P.G. Shao, Z. Zheng, R. W. Ge, F. Watt. Measurement of cell motility on proton beam micromachined 3D scaffolds. Nuc. Instru. Method B, 231 413¡V418, 2005. (IF: 0.9, Tier 2 physics) (co-author)

26. K. N. Sulochana, Huapeng Fan, Seetharama Jois, S. Vivekanandan, Feng Sun, R. Manjunatha Kini, and Ruowen Ge. Peptides derived from human decorin leucine rich repeat 5 inhibit angiogenesis. J. Biol. Chem. 280: 27935-27948, 2005. (IF: 5.8, Tier 1) (main-author)

27. Lei Ye, Husnain Kh. Haider, Shujia Jiang, Lieng H. Ling, Ruowen Ge, Peter K. Law, Eugene K.W. Sim. Reversal of myocardial injury using genetically modulated human skeletal myoblasts in a rodent cryoinjured heart model. Eur. J. Heart Fail., 7(6):945-52, 2005. (IF: 3.3, Tier 2) (co-author)

28. Lei Ye, Husnain Kh Haider, Shujia Jiang, Ruowen Ge, Peter K Law, Eugene KW Sim. In vitro functional assessment of human skeletal myoblast after transduction with adenovirus bicistronic vector carrying human VEGF165 and Angiopoietin-1. J. Heart Lung Transplant. 24:1393¡V1402, 2005. (IF: 2.8, Tier 2) (co-author)

29. Winston S.N. Shim, Wei Li, Li Zhang, Shiqi Li, Hwee Choo Ong, In-Chin Song, Akanksha Bapna, Ruowen Ge, Yean Teng Lim, Seng Chye Chuah, Eugene K.W. Sim and Philip Wong. Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. J. Biomed. Sci, 13:579-91, 2006. (IF: 1.7, Tier 3) (co-author)

30. Wang Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair. J. Mol. Cell. Cardiol. 40:736-45, 2006. (IF: 4.9, Tier 1) (co-author)

31. Ye L, Haider HK, Jiang S, Tan RS, Ge R, Law PK, Sim EK. Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF(165) and angiopoietin-1. Eur. J. Heart Fail. 9(1):15-22, 2007. (IF: 3.3, Tier 2) (co-author)

32. Sulochana, K.N. and R. Ge. Developing Antiangiogenic Peptide Drugs for Angiogenesis-Related Diseases. Curr. Pharma. Des., 13(20):2074-86, 2007.

33. Lu Z, Chen PCY, Nam J, Ge RW, Lin W. A micromanipulation system with dynamic force-feedback for automatic batch microinjection. J. Micromech. Microeng. 17 (2): 314-321, 2007.

34. Ye L, Haider HKh, Jiang S, Tan RS, Toh WC, Ge R, Sim EK. Angiopoietin-1 for myocardial angiogenesis: a comparison between delivery strategies. Eur. J. Heart Fail. 9(5):458-65, 2007.

35. Ye, L, Kh H Haider, RS Tan, WC Toh, PK Law, WB Tan, LP Su, W Zhang, R Ge, Y Zhang,
Y T Lim and E K W Sim, "Transplantation of nanoparticle transfected skeletal myoblasts
over expressing vascular endothelial growth factor 165 for cardiac repair.". Circulation 116(11 Suppl):I113-20, 2007.

36. Sharghi-Namini, S., H. Fan, K.N. Sulochana, P. Potturi, W. Xiang, Y-S Chong, Z. Wang, H. Yang, R. Ge. The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor. Biochem. Biophy. Res. Comm. 27, 371(2):215-9, 2008.

37. Fan, H., K.N. Sulochana, Y-S Chong and R. Ge. Decorin Derived Antiangiogenic Peptide LRR5 Inhibits Endothelial Cell Migration By Interfering With VEGF-Stimulated NO Release Int. J. Biochem. Cell Biol., 40 (10), 2120-2128, 2008.

38. He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454, 1123-1126, 2008.

39. Yuan, P., M. Bartlam, Z. Lou, S. Chen, J. Zhou, X. He, Z. Lv, R. Ge, X. Li, T. Deng, E. Fodor, Z. Rao & Y. Liu. Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site. Nature 458, 909-913, 2009.

40. Hou H, Zhang X, Tang T, Dai K, Ge R. Enhancement of bone formation by genetically-engineered bone marrow stromal cells expressing BMP-2, VEGF and angiopoietin-1.
Biotechnol. Lett. 2009 Aug; 31(8):1183-9.
41. Kwong S, Woods AE, Mirtschin PJ, Ge R, Kini RM. The recruitment of blood coagulation factor X into snake venom gland as a toxin: the role of promoter Cis-elements in its expression. Thromb. Haemost. 2009 Sep;102(3):469-78.

42. Jia, J., J. Wang, M. Teh, W. Sun, J. Zhang, I. Kee, P. K-H Chow, R. C. M-Y. Liang, M. C.M. Chung and R. Ge.. Identification Of Proteins Differentially Expressed Between Capillary Endothelial Cells Of Hepatocellular Carcinoma And Normal Liver In An Orthotopic Rat Tumor Model Using 2D-DIGE. Proteomics, 10:224-34, 2010.

43. Xiang W, Ke Z, Zhang Y, Cheng GH, Irwan ID, Sulochana KN, Potturi P, Wang Z, Yang H, Wang J, Zhuo L, Kini RM, Ge R. Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumor growth in mice. J. Cell. Mol. Med. 15:359-74, 2011.

44. Wang JY, Xu XY, Jia JH, Wu CH, Ge RW. Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma. Chin Med J (Engl). 123: 730-733, 2010.

45. Ye, Lei; Zhang, Wei; Su, Li-Ping; Haider, Husnain K; Poh, Kian-Keong; Galupo, Mary J; Songco, Geronica; Ge, Ruo-Wen; Tan, Huay-Cheem; Sim, Eugene K W. Nanoparticle based delivery of hypoxia-regulated VEGF transgene system combined with myoblast engraftment for myocardial repair. Biomaterials 32 (9): 2424-31, 2011.

46. Zhang, Y; M. Chen; S. Venugopal; Y. Zhou; W. Xiang; Y-H. Li; Q. Lin; R.M. Kini; Y-S. Chong and R. Ge. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis. 2: e153, 2011.

47. Kumar, S., S. Sharghi-Namini, N. Rao and R. Ge. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am. J. Pathol., 181(3):1056-68, 2012.

48. Ge R, Tan E, Sharghi-Namini S, Asada HH. Exosomes in cancer microenvironment and beyond: have we overlooked these extracellular messengers? Cancer Microenviron. 2012 May 15.

49. Wood LB, Ge R, Kamm RD, Asada HH. Nascent vessel elongation rate is inversely related to diameter in in vitro angiogenesis. Integr Biol 2012 Jul 31. [Epub ahead of print] PMID: 22847074.