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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-120816-1
Gutierrez, Alejandro
Email: alejandro.gutierrez@childrens.harvard.edu
URL:
Affiliation: Alejandro Gutierrez Lab
Address: Children’s Hospital Boston 300 Longwood Avenue Karp 8 Boston MA 02115 USA
Country: United States
Phone: 617-919-3660
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Mansour, M.R., He, S., Li, Z., Lobbardi, R., Abraham, B.J., Hug, C., Rahman, S., Leon, T.E., Kuang, Y.Y., Zimmerman, M.W., Blonquist, T., Gjini, E., Gutierrez, A., Tang, Q., Garcia-Perez, L., Pike-Overzet, K., Anders, L., Berezovskaya, A., Zhou, Y., Zon, L.I., Neuberg, D., Fielding, A.K., Staal, F.J.T., Langenau, D.M., Sanda, T., Young, R.A., Look, A.T. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 215(7):1929-1945
Burns, M.A., Liao, Z.W., Yamagata, N., Pouliot, G.P., Stevenson, K.E., Neuberg, D.S., Thorner, A.R., Ducar, M., Silverman, E.A., Hunger, S.P., Loh, M.L., Winter, S.S., Dunsmore, K.P., Wood, B., Devidas, M., Harris, M.H., Silverman, L.B., Sallan, S.E., Gutierrez, A. (2018) Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 32(10):2126-2137
Lobbardi, R., Pinder, J., Martinez-Pastor, B., Theodorou, M., Blackburn, J.S., Abraham, B.J., Namiki, Y., Mansour, M., Abdelfattah, N.S., Molodtsov, A., Alexe, G., Toiber, D., de Waard, M., Jain, E., Boukhali, M., Lion, M., Bhere, D., Shah, K., Gutierrez, A., Stegmaier, K., Silverman, L.B., Sadreyev, R.I., Asara, J.M., Oettinger, M.A., Haas, W., Look, A.T., Young, R.A., Mostoslavsky, R., Dellaire, G., Langenau, D.M. (2017) TOX regulates growth, DNA repair, and genomic instability in T-cell Acute Lymphoblastic Leukemia. Cancer discovery. 7(11):1336-1353
Harrison, N.R., Laroche, F.J., Gutierrez, A., Feng, H. (2016) Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Advances in experimental medicine and biology. 916:335-69
Gutierrez, A., Feng, H., Stevenson, K., Neuberg, D.S., Calzada, O., Zhou, Y., Langenau, D.M., Look, A.T. (2014) Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. British journal of haematology. 166(1):84-90
Gutierrez, A., Pan, L., Groen, R.W., Baleydier, F., Kentsis, A., Marineau, J., Grebliunaite, R., Kozakewich, E., Reed, C., Pflumio, F., Poglio, S., Uzan, B., Clemons, P., Verplank, L., An, F., Burbank, J., Norton, S., Tolliday, N., Steen, H., Weng, A.P., Yuan, H., Bradner, J.E., Mitsiades, C., Look, A.T., and Aster, J.C. (2014) Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J. Clin. Invest.. 124(2):644-655
Rudner, L.A., Brown, K.H., Dobrinski, K.P., Bradley, D.F., Garcia, M.I., Smith, A.C., Downie, J.M., Meeker, N.D., Look, A.T., Downing, J.R., Gutierrez, A., Mullighan, C.G., Schiffman, J.D., Lee, C., Trede, N.S., and Frazer, J.K. (2011) Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 30(41):4289-96
Gutierrez, A., Snyder, E.L., Marino-Enriquez, A., Zhang, Y.X., Sioletic, S., Kozakewich, E., Grebliunaite, R., Ou, W.B., Sicinska, E., Raut, C.P., Demetri, G.D., Perez-Atayde, A.R., Wagner, A.J., Fletcher, J.A., Fletcher, C.D., and Look, A.T. (2011) Aberrant AKT activation drives well-differentiated liposarcoma. Proceedings of the National Academy of Sciences of the United States of America. 108(39):16386-91
Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603
Feng, H., Stachura, D.L., White, R.M., Gutierrez, A., Zhang, L., Sanda, T., Jette, C.A., Testa, J.R., Neuberg, D.S., Langenau, D.M., Kutok, J.L., Zon, L.I., Traver, D., Fleming, M.D., Kanki, J.P., and Look, A.T. (2010) T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 18(4):353-366
Rhodes, J., Amsterdam, A., Sanda, T., Moreau, L.A., McKenna, K., Heinrichs, S., Ganem, N.J., Ho, K.W., Neuberg, D.S., Johnston, A., Ahn, Y., Kutok, J.L., Hromas, R., Wray, J., Lee, C., Murphy, C., Radke, I., Downing, J.R., Fleming, M.D., Macconaill, L.E., Amatruda, J.F., Gutierrez, A., Galinsky, I., Stone, R.M., Ross, E.A., Pellman, D.S., Kanki, J.P., and Look, A.T. (2009) Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression. Molecular and cellular biology. 29(21):5911-5922
Feng, H., Langenau, D.M., Madge, J.A., Quinkertz, A., Gutierrez, A., Neuberg, D.S., Kanki, J.P., and Look, A.T. (2007) Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. British journal of haematology. 138(2):169-175

NON-ZEBRAFISH PUBLICATIONS
2012
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches.
Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PLoS ONE 2012; 7(6):e39725

2011
Aberrant AKT activation drives well-differentiated liposarcoma.
Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT. Proc. Natl. Acad. Sci. U.S.A. 2011; 108(39):16386-91

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT. Blood 2011; 118(15):4169-73

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. Nature 2011; 471(7336):104-9

2010
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. Cancer Cell 2010; 18(4):353-66

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT. J. Clin. Oncol. 2010; 28(24):3816-23

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. Blood 2010; 115(14):2845-51

Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea.
Grace RF, Su H, Sena L, Poussaint TY, Heeney MM, Gutierrez A. Am. J. Hematol. 2010; 85(2):135-7

Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.
Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. J. Steroid Biochem. Mol. Biol. 2010; 121(3-5):546-55

2009
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. Blood 2009; 114(3):647-50

2007
NOTCH and PI3K-AKT pathways intertwined.
Gutierrez A, Look AT. Cancer Cell 2007; 12(5):411-3


2000
Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range.
Singh G, Gutierrez A, Xu K, Blair IA. Anal. Chem. 2000; 72(14):3007-13