ZFIN ID: ZDB-PERS-120309-3
Facchinello, Nicola
Email: nicola.facchinello@unipd.it
URL: http://www.researcherid.com/rid/N-7739-2017
Affiliation: Tiso Lab
Address: Developmental Genetics Lab Department of Biology University of Padova via U. Bassi 58/B Padova, I-35121 Italy
Country: Italy
Phone: +39 049 8276349
Fax: +39 049 8276300
ORCID ID: 0000-0003-4898-4064


BIOGRAPHY AND RESEARCH INTERESTS
Qualifications

September 2004: Bachelor's degree in Industrial Biotechnology with the final score of 100/110
Thesis :“ Preparation of biosensor with activity γ-secretase” (Supervisor: Dott. Cristina Fasolato, Department of Biomedical Sciences, University of Padova)

October 2006: Master’s degree in Industrial Biotechnology with the final score of 110/110.
Thesis: “The effects of Ankrd2 alteration in cell cycle regulation during muscle differentiation” (Supervisor: Prof. Gerolamo Lanfranchi, Department of Biology, University of Padova)

17 march 2010: PhD in Biotechnology, 
Doctoral School of Biochemistry and Biotechnology 

Thesis: “Conditional inactivation of Emilin1 and Col6a1 genes”. (Supervisor: Prof. Giorgio Bressan, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova)


PUBLICATIONS
Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100
Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M.T., Yang, H., Beffagna, G., Campanaro, S., Tam, W.L., Argenton, F., Lim, B., Korzh, V., Tiso, N. (2020) miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 9(3):
Morbiato, E., Frigato, E., Dinarello, A., Maradonna, F., Facchinello, N., Argenton, F., Carnevali, O., Dalla Valle, L., Bertolucci, C. (2019) Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor. Cells. 8(11):
Martorano, L., Peron, M., Laquatra, C., Lidron, E., Facchinello, N., Meneghetti, G., Tiso, N., Rasola, A., Ghezzi, D., Argenton, F. (2019) The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria. Disease models & mechanisms. 12(3):
Meneghetti, G., Skobo, T., Chrisam, M., Facchinello, N., Fontana, C.M., Bellesso, S., Sabatelli, P., Raggi, F., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2019) The epg5 knockout zebrafish line: a model to study Vici syndrome. Autophagy. 15(8):1438-1454
Facchinello, N., Skobo, T., Meneghetti, G., Colletti, E., Dinarello, A., Tiso, N., Costa, R., Gioacchini, G., Carnevali, O., Argenton, F., Colombo, L., Valle, L.D. (2018) Author Correction: nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports. 8:4445
Giuliodori, A., Beffagna, G., Marchetto, G., Fornetto, C., Vanzi, F., Toppo, S., Facchinello, N., Santimaria, M., Vettori, A., Rizzo, S., Della Barbera, M., Pilichou, K., Argenton, F., Thiene, G., Tiso, N., Basso, C. (2018) Loss of cardiac Wnt/β-catenin signalling in Desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention. Cardiovascular research. 114(8):1082-1097
Vettori, A., Greenald, D., Wilson, G.K., Peron, M., Facchinello, N., Markham, E., Sinnakaruppan, M., Matthews, L.C., McKeating, J.A., Argenton, F., van Eeden, F.J.M. (2017) Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. Proceedings of the National Academy of Sciences of the United States of America. 114(37):9948-9953
Facchinello, N., Tarifeño-Saldivia, E., Grisan, E., Schiavone, M., Peron, M., Mongera, A., Ek, O., Schmitner, N., Meyer, D., Peers, B., Tiso, N., Argenton, F. (2017) Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports. 7:9605
Facchinello, N., Skobo, T., Meneghetti, G., Colletti, E., Dinarello, A., Tiso, N., Costa, R., Gioacchini, G., Carnevali, O., Argenton, F., Colombo, L., Dalla Valle, L. (2017) nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports. 7:4371
Khatri, D., Zizioli, D., Tiso, N., Facchinello, N., Vezzoli, S., Gianoncelli, A., Memo, M., Monti, E., Borsani, G., Finazzi, D. (2016) Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish. Scientific Reports. 6:37660
Pozzobon, T., Facchinello, N., Bossi, F., Capitani, N., Benagiano, M., Di Benedetto, G., Zennaro, C., West, N., Codolo, G., Bernardini, M., Baldari, C.T., D'Elios, M.M., Pellegrini, L., Argenton, F., de Bernard, M. (2016) Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway. Scientific Reports. 6:18785
Facchinello, N., Schiavone, M., Vettori, A., Argenton, F., Tiso, N. (2016) Monitoring Wnt Signaling in Zebrafish Using Fluorescent Biosensors. Methods in molecular biology (Clifton, N.J.). 1481:81-94
Casari, A., Schiavone, M., Facchinello, N., Vettori, A., Meyer, D., Tiso, N., Moro, E., Argenton, F. (2014) A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Developmental Biology. 396(1):81-93
Moro, E., Vettori, A., Porazzi, P., Schiavone, M., Rampazzo, E., Casari, A., Ek, O., Facchinello, N., Astone, M., Zancan, I., Milanetto, M., Tiso, N., and Argenton, F. (2013) Generation and application of signaling pathway reporter lines in zebrafish. Molecular genetics and genomics : MGG. 288(5-6):231-242

NON-ZEBRAFISH PUBLICATIONS
The effects of Ankrd2 alteration indicate its involvement in cell cycle regulation during muscle differentiation. Bean C, Facchinello N, Faulkner G, Lanfranchi G. Biochim Biophys Acta. 2008 Jun;1783(6):1023-35

Lentiviral-mediated RNAi in vivo silencing of Col6a1, a gene with complex tissue specific expression pattern. Frka K, Facchinello N, Del Vecchio C, Carpi A, Curtarello M, Venerando R, Angelin A, Parolin C, Bernardi P, Bonaldo P, Volpin D, Braghetta P, Bressan GM. J Biotechnol. 2009 Apr 20;141(1-2):8-17

Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure. Litteri G, Carnevale D, D'Urso A, Cifelli G, Braghetta P, Damato A, Bizzotto D, Landolfi A, Ros FD, Sabatelli P, Facchinello N, Maffei A, Volpin D, Colombatti A, Bressan GM, Lembo G. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2178-84