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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-120309-2
Cole, Nicholas
Email: nicholas.cole@mq.edu.au
URL: http://awc.alumni.mq.edu.au/s/1404/give/1col.aspx?sid=1404&gid=1&pgid=845
Affiliation: Nicholas Cole Lab
Address: Australian School of Advanced Medicine 75 Talavera Road, Macquarie University, NSW 2109, Australia
Country: Australia
Phone: + 61 (0) 2 9850 2740
Fax: +61 (0) 2 9812 3600
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Aksoy, Y.A., Nguyen, D.T., Chow, S., Chung, R.S., Guillemin, G.J., Cole, N.J., Hesselson, D. (2019) Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos. Communications biology. 2:198
Kumar, S.S., Tandberg, J.I., Penesyan, A., Elbourne, L.D.H., Suarez-Bosche, N., Don, E., Skadberg, E., Fenaroli, F., Cole, N., Winther-Larsen, H.C., Paulsen, I.T. (2018) Dual Transcriptomics of Host-Pathogen Interaction of Cystic Fibrosis Isolate Pseudomonas aeruginosa PASS1 With Zebrafish. Frontiers in cellular and infection microbiology. 8:406
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S.S.L., Formella, I., Hortle, E., Yuan, K.C., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2018) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 28(4):698
Robinson, K.J., Yuan, K.C., Don, E.K., Hogan, A.L., Winnick, C.G., Tym, M.C., Lucas, C.W., Shahheydari, H., Watchon, M., Blair, I.P., Atkin, J.D., Nicholson, G.A., Cole, N.J., Laird, A.S. (2018) Motor Neuron Abnormalities Correlate with Impaired Movement in Zebrafish that Express Mutant Superoxide Dismutase 1. Zebrafish. 16(1):8-14
Acosta, J.R., Watchon, M., Yuan, K.C., Fifita, J., Svahn, A.J., Don, E.K., Blair, I.P., Nicholson, G.A., Cole, N.J., Goldsbury, C., Laird, A.S. (2018) Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease. Biology Open. 7(10):
Formella, I., Svahn, A.J., Radford, R.A.W., Don, E.K., Cole, N.J., Hogan, A., Lee, A., Chung, R.S., Morsch, M. (2018) Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo. Redox Biology. 19:226-234
Svahn, A.J., Don, E.K., Badrock, A.P., Cole, N.J., Graeber, M.B., Yerbury, J.J., Chung, R., Morsch, M. (2018) Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons. Acta Neuropathologica. 136(3):445-459
Gwee, S.S.L., Radford, R.A.W., Chow, S., Syal, M.D., Morsch, M., Formella, I., Lee, A., Don, E.K., Badrock, A.P., Cole, N.J., West, A.K., Cheung, S.N.S., Chung, R.S. (2018) Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. Cellular and molecular life sciences : CMLS. 75(23):4269-4285
Chen, L., Watson, C., Morsch, M., Cole, N.J., Chung, R.S., Saunders, D.N., Yerbury, J.J., Vine, K.L. (2017) Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles. Frontiers in neuroscience. 11:476
Lee, A., Rayner, S.L., Gwee, S.S.L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A.K., Don, E.K., Cole, N.J., Yang, S., Williams, K.L., Yerbury, J.J., Blair, I.P., Atkin, J.D., Molloy, M.P., Chung, R.S. (2017) Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.. Cellular and molecular life sciences : CMLS. 75(2):335-354
Watchon, M., Yuan, K.C., Mackovski, N., Svahn, A.J., Cole, N.J., Goldsbury, C., Rinkwitz, S., Becker, T.S., Nicholson, G.A., Laird, A.S. (2017) Calpain inhibition is protective in Machado-Joseph disease zebrafish due to induction of autophagy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(32):7782-7794
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S., Formella, I., Hortle, E., Yuan, K., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2017) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 26(14):2616-2626
Zhang, Y., Nguyen, D.T., Olzomer, E.M., Poon, G.P., Cole, N.J., Puvanendran, A., Phillips, B.R., Hesselson, D. (2017) Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell chemical biology. 24(4):471-480.e4
Keightley, M.C., Carradice, D.P., Layton, J.E., Pase, L., Bertrand, J.Y., Wittig, J.G., Dakic, A., Badrock, A.P., Cole, N.J., Traver, D., Nutt, S.L., McCoey, J., Buckle, A.M., Heath, J.K., Lieschke, G.J. (2017) The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nature communications. 8:14911
Morsch, M., Radford, R.A., Don, E.K., Lee, A., Hortle, E., Cole, N.J., Chung, R.S. (2017) Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy. Journal of visualized experiments : JoVE. (120)
Don, E.K., Formella, I., Badrock, A.P., Hall, T.E., Morsch, M., Hortle, E., Hogan, A., Chow, S., Gwee, S.S., Stoddart, J.J., Nicholson, G., Chung, R., Cole, N.J. (2017) A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease. Zebrafish. 14(1):69-72
Masselink, W., Cole, N.J., Fenyes, F., Berger, S., Sonntag, C., Wood, A., Nguyen, P.D., Cohen, N., Knopf, F., Weidinger, G., Hall, T.E., Currie, P.D. (2016) A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature. 535(7613):542-6
Don, E.K., de Jong-Curtain, T.A., Doggett, K., Hall, T.E., Heng, B., Badrock, A.P., Winnick, C., Nicholson, G.A., Guillemin, G.J., Currie, P.D., Hesselson, D., Heath, J.K., Cole, N.J. (2016) Genetic basis of hindlimb loss in a naturally occurring vertebrate model. Biology Open. 5(3):359-66
Morsch, M., Radford, R., Lee, A., Don, E.K., Badrock, A.P., Hall, T.E., Cole, N.J., Chung, R. (2015) In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord. Frontiers in Cellular Neuroscience. 9:321
Nguyen, P.D., Hollway, G.E., Sonntag, C., Miles, L.B., Hall, T.E., Berger, S., Fernandez, K.J., Gurevich, D.B., Cole, N.J., Alaei, S., Ramialison, M., Sutherland, R.L., Polo, J.M., Lieschke, G.J., Currie, P.D. (2014) Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1. Nature. 512(7514):314-8
Acosta, J.R., Goldsbury, C., Winnick, C., Badrock, A.P., Fraser, S.T., Laird, A.S., Hall, T.E., Don, E.K., Fifita, J.A., Blair, I.P., Nicholson, G.A., Cole, N.J. (2014) Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PLoS One. 9(6):e90572
Veilleux, H.D., Van Herwerden, L., Cole, N.J., Don, E.K., De Santis, C., Dixson, D.L., Wenger, A.S., and Munday, P.L. (2013) Otx2 expression and implications for olfactory imprinting in the anemonefish, Amphiprion percula. Biology Open. 2(9):907-915
Don, E.K., Currie, P.D., Cole, N.J. (2013) The evolutionary history of the development of the pelvic fin/hindlimb. Journal of anatomy. 222:114-133
Bower, N.I., Castillo, D.G., Cole, N.J., Hollway, G.E., Lee, H.T., Assinder, S., and Johnston, I.A. (2012) STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle. The Journal of biological chemistry. 287(52):43936-43949
Cole, N.J., Currie, P. (2012) Shaping muscle bioarchitecture for the fin to limb transition.. Bioarchitecture. 2(3):98-103
Cole, N.J., Hall, T.E., Don, E.K., Berger, S., Boisvert, C.A., Neyt, C., Ericsson, R., Joss, J., Gurevich, D.B., and Currie, P.D. (2011) Development and evolution of the muscles of the pelvic fin. PLoS Biology. 9(10):e1001168
Don, E.K., Hall, T.E., Currie, P.D., and Cole, N.J. (2011) Morphology of pelvic fin loss in a zebrafish strain (Danio rerio). Journal of morphology. 272(5):583-589
Cole, N.J., Currie, P.D. (2007) Insights from sharks: evolutionary and developmental models of fin development.. Developmental dynamics : an official publication of the American Association of Anatomists. 236(9):2421-31
Bryson-Richardson, R.J., Berger, S., Schilling, T.F., Hall, T.E., Cole, N.J., Gibson, A.J., Sharpe, J., and Currie, P.D. (2007) FishNet: an online database of zebrafish anatomy. BMC Biology. 5(1):34
Hall, T.E., Bryson-Richardson, R.J., Berger, S., Jacoby, A.S., Cole, N.J., Hollway, G.E., Berger, J., and Currie, P.D. (2007) The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin {alpha}2-deficient congenital muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 104(17):7092-7097
Hollway, G.E., Bryson-Richardson, R.J., Berger, S., Cole, N.J., Hall, T.E., and Currie, P.D. (2007) Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Developmental Cell. 12(2):207-219
Cole, N.J., Neyt, C., Currie, P.D. (2005) Morphogenesis and evolution of vertebrate appendicular muscle formation. Mechanisms of Development. 122:S160
Hall, T.E., Bryson-Richardson, R.J., Cole, N.J., Currie, P.D. (2005) Muscle stem cells and regeneration in zebrafish models of muscular dystrophies. Mechanisms of Development. 122:S131
Haines, L., Neyt, C., Gautier, P., Keenan, D.G., Bryson-Richardson, R.J., Hollway, G.E., Cole, N.J., Currie, P.D. (2004) Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish. Development (Cambridge, England). 131(19):4857-4869

NON-ZEBRAFISH PUBLICATIONS
Cole, N., Hall, T., Don, E., Berger, S., Boisvert, C., Neyt, C., Ericsson, R., Joss J., Gurevich, D., Currie, P. Development and Evolution of the Muscles of the Pelvic Fin. PLoS Biology. 2011; 9 (10)

Assinder, S., Cole, N. Does TGF-β induced formation of actin stress fibres reinforce Smad dependent TGF-β signalling in the prostate? Medical hypotheses. 2011; 76:802-4

Cole, N., Currie, P. Insights from sharks: Evolutionary and developmental models of fin development. Developmental dynamics : an official publication of the American Association of Anatomists. 2007; 236:2421-31.

Nihei, Y., Kobiyama, A., Ikeda, D., Ono, Y., Ohara, S., Cole, N., Johnston, I., Watabe, S. Molecular cloning and mRNA expression analysis of carp embryonic, slow and cardiac myosin heavy chain isoforms. The Journal of experimental biology. 2006; 209:188-98.

Shi, B., Du, X., Chen, J., Fu, L., Morsch, M., Lee, A., Liu, Y., Cole, N., Chung, R. Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons. Small. 2017;13(20).

Williams et al. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. The discovery of a novel disease gene that provides a clear molecular link between ALS and FTD. Nature Communications. 2016; 7:11253.

Radford, R. Morsch M, Rayner S, Cole N, Pountne D and Chung R. The established and emerging roles of astrocytes and microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Frontiers in Cellular Neuroscience. 2015; 9:414.

Tickle, C., and Cole, N.J. Morphological diversity: Taking the spine out of three-spine stickleback. Current Biology. 2004; 14:R422-R424.

Cole, N.J., Hall, T.E., Martin, C.I., Chapman, M.A., Kobiyama, A., Nihei, Y., Watabe, S., and Johnston, I.A. Temperature and the expression of myogenic regulatory factors (MRFs) and myosin heavy chain isoforms during embryogenesis in the common carp Cyprinus carpio L. Journal of Experimental Biology. 2004; 207:4239-4248.

Hall, T.E., Cole, N.J., and Johnston, I.A. Temperature and the expression of seven muscle-specific protein genes during embryogenesis in the Atlantic cod Gadus morhua L. Journal of Experimental Biology. 2003; 206:3187-3200.

Cole, N.J., Tanaka, M., Prescott, A., and Tickle, C. Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback. Current Biology. 2003; 13:R951-R952.

Temple, G.K., Cole, N.J., and Johnston, I.A. Embryonic temperature and the relative timing of muscle-specific genes during development in herring (Clupea harengus L.). Journal of Experimental Biology. 2001; 204:3629-3637.

Cole, N.J., and Johnston, I.A. Plasticity of myosin heavy chain expression with temperature acclimation is gradually acquired during ontogeny in the common carp (Cyprinus carpio L.). Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology. 2001; 171:321-326.

Wakeling, J.M., Cole, N.J., Kemp, K.M., and Johnston, I.A. The biomechanics and evolutionary significance of thermal acclimation in the common carp Cyprinus carpio. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 2000; 279:R657-R665.

Temple, G.K., Cole, N.J.C., and Johnston, I.A. Temperature and the expression patterns of the myogenic regulatory factors during early development in herring (Clupea harengus L.). Comparative Biochemistry and Physiology Part A Molecular and Integrative Physiology. 2000; 126A:S144-S144.

Cole, N.J.C., and Johnston, I.A. Plasticity of myosin heavy chain mRNA expression with temperature acclimation is gradually acquired during ontogeny in the common carp. Comparative Biochemistry and Physiology Part A Molecular and Integrative Physiology. 2000; 126A:S30-S30.

Cole, N.J., Abercromby, M., and Vieira, V.L.A. and Johnston, I.A. Embryonic temperature modulates muscle growth characteristics in larval and juvenile herring. Journal of Experimental Biology. 1998; 201:623-646.

James, R.S., Cole, N.J., Davies, M.L.F., and Johnston, I.A. Scaling of intrinsic contractile properties and myofibrillar protein composition of fast muscle in the fish Myoxocephalus scorpius L. Journal of Experimental Biology. 1998; 201:901-912.

Johnston, I.A., Cole, N.J., Vieira, V.L.A., and Davidson, I. Temperature and developmental plasticity of muscle phenotype in herring larvae. Journal of Experimental Biology. 1997; 200:849-868.