ZFIN Person: Liu, Feng

ZFIN ID: ZDB-PERS-110907-1

Liu, Feng

Email:	liuf@ioz.ac.cn
URL:	http://www.biomembrane.ioz.ac.cn/Enliuf.asp
Affiliation:	Liu Lab
Address:	State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences 1 Beichen West Road Chaoyang District Beijing, 100101 China
Country:	China
Phone:	86-10-64807307
Fax:	86-10-64807313
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

We are interested in Hematopoiesis and Cardiovascular development biology, with particular focus on Hemangioblast formation, Artery/Vein specification and Hematopoietic Stem Cell (HSC) development, using the zebrafish as a model organism. Our previous work has demonstrated that several ETS transcription factors involved in blood and endothelial development. Our current work focuses on key signal transduction pathways and gene regulatory network (GRN) controlling hematopoietic/cardiovascular stem cell differentiation to better understand molecular mechanisms of programming/reprogramming of these cells for potential therapeutic application.

PUBLICATIONS

Sun, B.J., Li, W.M., Lv, P., Wen, G.N., Wu, D.Y., Tao, S.A., Liao, M.L., Yu, C.Q., Jiang, Z.W., Wang, Y., Xie, H.X., Wang, X.F., Chen, Z.Q., Liu, F., Du, W.G. (2024) Genetically encoded lizard color divergence for camouflage and thermoregulation. Molecular Biology and Evolution. 41(2):

Huang, W., Xiong, T., Zhao, Y., Heng, J., Han, G., Wang, P., Zhao, Z., Shi, M., Li, J., Wang, J., Wu, Y., Liu, F., Xi, J.J., Wang, Y., Zhang, Q.C. (2024) Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human. Nature Genetics. 56(1):124-135

Li, Y., Li, C., Liu, M., Liu, S., Liu, F., Wang, L. (2023) The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling. Development (Cambridge, England). 150(21):

Sun, Y., Heng, J., Liu, F., Zhang, S., Liu, P. (2023) Isolation and proteomic study of fish liver lipid droplets. Biophysics reports. 9:120133120-133

Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):

Xia, J., Liu, M., Zhu, C., Liu, S., Ai, L., Ma, D., Zhu, P., Wang, L., Liu, F. (2023) Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Research. 33(6):448-463

Heng, J., Shi, B., Zhou, J.Y., Zhang, Y., Ma, D., Yang, Y.G., Liu, F. (2023) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2212212120e2212212120

Shi, B., Heng, J., Zhou, J.Y., Yang, Y., Zhang, W.Y., Koziol, M.J., Zhao, Y.L., Li, P., Liu, F., Yang, Y.G. (2022) Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish. Cell Research. 32(8):715-728

Li, Y., Tang, C., Liu, F., Zhu, C., Liu, F., Zhu, P., Wang, L. (2022) DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development (Cambridge, England). 149(10):

Wu, X., Zhang, H., Zhang, B., Zhang, Y., Wang, Q., Shen, W., Wu, X., Li, L., Xia, W., Nakamura, R., Liu, B., Liu, F., Takeda, H., Meng, A., Xie, W. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science advances. 7:eabl3858

Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:

Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):

Li, Y., Liu, F. (2021) DNA Methylation Reshapes Sex Development in Zebrafish. Genomics, proteomics & bioinformatics. 19(1):44-47

Lv, P., Ma, D., Gao, S., Zhang, Y., Bae, Y.K., Liang, G., Gao, S., Choi, J.H., Kim, C.H., Wang, L., Liu, F. (2020) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 15(3):749-760

Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202

Shi, B., Zhang, J., Heng, J., Gong, J., Zhang, T., Li, P., Sun, B.F., Yang, Y., Zhang, N., Zhao, Y.L., Wang, H.L., Liu, F., Zhang, Q.C., Yang, Y.G. (2020) RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome biology. 21:120

Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696

Lu, X., Zhang, Y., Liu, F., Wang, L. (2020) Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. Journal of immunology (Baltimore, Md. : 1950). 204(9):2447-2454

Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839

Tu, H.Q., Qin, X.H., Liu, Z.B., Song, Z.Q., Hu, H.B., Zhang, Y.C., Chang, Y., Wu, M., Huang, Y., Bai, Y.F., Wang, G., Han, Q.Y., Li, A.L., Zhou, T., Liu, F., Zhang, X.M., Li, H.Y. (2018) Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nature communications. 9:5277

Choi, J.P., Wang, R., Yang, X., Wang, X., Wang, L., Ting, K.K., Foley, M., Cogger, V., Yang, Z., Liu, F., Han, Z., Liu, R., Baell, J., Zheng, X. (2018) Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations. Science advances. 4:eaau0731

Wang, N., Zhang, B., Jin, F., Gao, D., Liu, F., Liu, H., Jiang, Y. (2018) Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway. Journal of pharmaceutical and biomedical analysis. 160:314-322

Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports. 18:1922-1934

Wang, L., Liu, Z., Lin, H., Ma, D., Tao, Q., Liu, F. (2017) Epigenetic regulation of left-right asymmetry by DNA methylation. The EMBO journal. 36(20):2987-2997

Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., Jia, Q., Wang, X., Qin, G., Yao, J., Wang, X., Zheng, Q., Zhang, R., Li, Y., Luo, A., Zhang, N., Shi, G., Wang, Y., Ying, H., Liu, Z., Wang, H., Meng, A., Zhou, Q., Wei, H., Liu, F., Zhao, J. (2017) Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 130(20):2161-2170

Zhang, C., Chen, Y., Sun, B., Wang, L., Yang, Y., Ma, D., Lv, J., Heng, J., Ding, Y., Xue, Y., Lu, X., Xiao, W., Yang, Y.G., Liu, F. (2017) m⁶A modulates haematopoietic stem and progenitor cell specification.. Nature. 549(7671):273-276

Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4

Yan, H., Zhang, C., Wang, Z., Tu, T., Duan, H., Luo, Y., Feng, J., Liu, F., Yan, X. (2017) CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Scientific Reports. 7:7442

Ma, D., Xue, Y., Zhang, Y., Sun, Y., Meng, A., Liu, F. (2016) The rising zebrafish research in China: Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society. Journal of genetics and genomics = Yi chuan xue bao. 43(10):617-620

Zhou, W., He, Q., Zhang, C., He, X., Cui, Z., Liu, F., Li, W. (2016) BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. eLIFE. 5

Wei, Y., Xu, J., Zhang, W., Wen, Z., Liu, F. (2016) RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). 143(12):2103-10

Wang, X.Q., Tang, Z.X., Yu, D., Cui, S.J., Jiang, Y.H., Zhang, Q., Wang, J., Yang, P.Y., Liu, F. (2016) Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 7(8):8823-38

Hu, M., Bai, Y., Zhang, C., Liu, F., Cui, Z., Chen, J., Peng, J. (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genetics. 12:e1005881

Ma, D., Liu, F. (2015) Genome Editing and Its Applications in Model Organisms. Genomics, proteomics & bioinformatics. 13(6):336-44

Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107

Wang, S., He, Q., Ma, D., Xue, Y., Liu, F. (2015) Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Developmental Cell. 34(6):621-31

Lu, X., Wei, Y., Liu, F. (2015) Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell discovery. 1:15027

Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27

Wang, H., Li, Y., Wang, S., Zhang, Q., Zheng, J., Yang, Y., Qi, H., Qu, H., Zhang, Z., Liu, F., Fang, X. (2015) Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. Biochemical and Biophysical Research Communications. 460(4):923-30

Tu, T., Zhang, C., Yan, H., Luo, Y., Kong, R., Wen, P., Ye, Z., Chen, J., Feng, J., Liu, F., Wu, J.Y., Yan, X. (2015) CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Research. 25(3):275-87

Zhou, Y., Ge, R., Wang, R., Liu, F., Huang, Y., Liu, H., Hao, Y., Zhou, Q., Wang, C. (2015) UXT potentiates angiogenesis by attenuating Notch signaling. Development (Cambridge, England). 142(4):774-86

He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106

Qiao, J., Cui, S.J., Xu, L.L., Chen, S.J., Yao, J., Jiang, Y.H., Peng, G., Fang, C.Y., Yang, P.Y., Liu, F. (2015) Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 6(2):1171-89

Wei, Y., Ma, D., Gao, Y., Zhang, C., Wang, L., Liu, F. (2014) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 124(10):1578-85

Ping, X.L., Sun, B.F., Wang, L., Xiao, W., Yang, X., Wang, W.J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.S., Zhao, X., Li, A., Yang, Y., Dahal, U., Lou, X.M., Liu, X., Huang, J., Yuan, W.P., Zhu, X.F., Cheng, T., Zhao, Y.L., Wang, X., Rendtlew Danielsen, J.M., Liu, F., and Yang, Y.G. (2014) Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Research. 24(2):177-189

Lu, X., Li, X., He, Q., Gao, J., Gao, Y., Liu, B., and Liu, F. (2013) miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Research. 23(12):1356-68

Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L., and Zhao, Y. (2013) Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology. 203(4):575-583

Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75

Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W., and Liu, J. (2013) Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 153(4):773-784

Zhang, C., Patient, R., and Liu, F. (2013) Hematopoietic stem cell development and regulatory signaling in zebrafish. Biochimica et biophysica acta. General subjects. 1830(2):2370-2374

Ma, D., Wei, Y., and Liu, F. (2013) Regulatory mechanisms of thymus and T cell development. Developmental and comparative immunology. 39(1-2):91-102

Ye, Z., Zhang, C., Tu, T., Sun, M., Liu, D., Lu, D., Feng, J., Yang, D., Liu, F., and Yan, X. (2013) Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nature communications. 4:2803

Ma, D., Wang, L., Wang, S., Gao, Y., Wei, Y., and Liu, F. (2012) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(51):21040-21045

Liu, Z., and Liu, F. (2012) Cautious use of fli1a:EGFP transgenic zebrafish in vascular research. Biochemical and Biophysical Research Communications. 427(1):223-226

Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10

Zhang, P., and Liu, F. (2011) In vivo imaging of hematopoietic stem cell development in the zebrafish. Frontiers of Medicine. 5(3):239-47

Miller, L.C., Freter, S., Liu, F., Taylor, J.S., Patient, R., and Begbie, J. (2010) Separating early sensory neuron and blood vessel patterning. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3297-3302

Ciau-Uitz, A., Liu, F., and Patient, R. (2010) Genetic control of hematopoietic development in Xenopus and zebrafish. The International journal of developmental biology. 54(6-7):1139-1143

Liu, F., and Patient, R. (2008) Genome-Wide Analysis of the Zebrafish ETS Family Identifies Three Genes Required for Hemangioblast Differentiation or Angiogenesis. Circulation research. 103(10):1147-1154

Liu, F., Walmsley, M., Rodaway, A., and Patient, R. (2008) Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development. Current biology : CB. 18(16):1234-1240

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Liu, F. and Wen, Z. (2002) Cloning and expression pattern of the lysozyme C gene in zebrafish. Mechanisms of Development. 113(1):69-72

NON-ZEBRAFISH PUBLICATIONS