ZFIN ID: ZDB-PERS-110815-1
Hu, Wei
Email: huwei@ihb.ac.cn
URL: http://sourcedb.cas.cn/sourcedb_ihb_cas/en/expert/pl/200907/t20090722_2156221.html
Affiliation: Wei Hu lab
Address: No. 7 Donghu South Road Wuhan, 430072 China
Country: China
Phone: 86 27 68780051
Fax: 86 27 68780051
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Education:
1997-2001: Fish Development and Molecular Genetics in the Graduate School of the Chinese Academy of Sciences, Ph.D program;
1991-1994: Hydrobiology in Institute of Hydrobiology, the Chinese Academy of Sciences. MSc program;
1987-1991: Zoology in Department of Biology, Nankai University, Tianjin, China. B.Sc program.

Professional Experience:
2007-present: Professor, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS;
2002-2007: Associate Professor, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS;
1996-2001: Research Associate, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS;
1994-1996: Research Assistant, Institute of Hydrobiology, CAS.

Research Interests
1. Fish reproductive biology.
2. Fish Genetic Engineering and ecological risk evaluation of transgenic fish.
3. Reprogramming mechanism of zebrafish somatic cloned embryos.


PUBLICATIONS
Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
Liang, F., Dong, Z., Ye, J., Hu, W., Bhandari, R.K., Mai, K., Wang, X. (2023) In vivo DNA methylation editing in zebrafish. Epigenetics. 18:21923262192326
Ye, D., Liu, T., Li, Y., Wang, Y., Hu, W., Zhu, Z., Sun, Y. (2023) Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set. Frontiers in endocrinology. 14:10443181044318
Lin, X., Liu, F., Meng, K., Liu, H., Zhao, Y., Chen, Y., Hu, W., Luo, D. (2022) Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Life (Basel, Switzerland). 12(9)
Sun, X., Tao, B., Wang, Y., Hu, W., Sun, Y. (2022) Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus. International Journal of Molecular Sciences. 23(11)
Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
Song, Y., Hu, W., Ge, W. (2021) Establishment of transgenic zebrafish (Danio rerio) models expressing fluorescence proteins in the oocytes and somatic supporting cells. General and comparative endocrinology. 314:113907
Song, Y., Peng, W., Luo, J., Zhu, Z., Hu, W. (2021) Organization of the gonadotropin-inhibitory hormone (Lpxrfa) system in the brain of zebrafish (Danio rerio). General and comparative endocrinology. 304:113722
Jia, S., Wu, X., Wu, Y., Cui, X., Tao, B., Zhu, Z., Hu, W. (2020) Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome. International journal of biological sciences. 16:3039-3049
Liu, Z.H., Li, Y.W., Hu, W., Chen, Q.L., Shen, Y.J. (2020) Mechanisms involved in tributyltin-enhanced aggressive behaviors and fear responses in male zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 220:105408
Feng, K., Cui, X., Song, Y., Tao, B., Chen, J., Wang, J., Liu, S., Sun, Y., Zhu, Z., Trudeau, V.L., Hu, W. (2019) Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish. Endocrinology. 161(1):
Zhang, Y., Li, Z., Hu, W., Liu, Z. (2019) A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues. Analytical chemistry. 91(15):10302-10309
Tao, B., Hu, H., Mitchell, K., Chen, J., Jia, H., Zhu, Z., Trudeau, V.L., Hu, W. (2018) Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of molecular cell biology. 10(5):388-401
Hu, H., Tao, B., Chen, J., Zhu, Z., Hu, W. (2018) Fam60al as a novel factor involved in reprogramming of somatic cell nuclear transfer in zebrafish (Danio rerio).. International journal of biological sciences. 14:78-86
Xia, H., Zhong, C., Wu, X., Chen, J., Tao, B., Xia, X., Shi, M., Zhu, Z., Trudeau, V.L., Hu, W. (2017) Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.. Genetics. 208(2):729-743
Luo, K., Li, Y., Xia, L., Hu, W., Gao, W., Guo, L., Tian, G., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Analysis of the expression patterns of the novel large multigene TRIM gene family (finTRIM) in zebrafish. Fish & shellfish immunology. 66:224-230
Luo, K., Li, Y., Ai, K., Xia, L., Zhang, J., Hu, W., Gao, W., Guo, L., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Bioinformatics and expression analysis of finTRIM genes in grass carp, Ctenopharyngodon idella. Fish & shellfish immunology. 66:217-223
Zhai, B., Hu, W., Sun, J., Chi, S., Lei, Y., Zhang, F., Zhong, C., Liu, Z. (2017) A two-photon fluorescent probe for nitroreductase imaging in living cells, tissues and zebrafish under hypoxia conditions. The Analyst. 142(9):1545-1553
Song, Y., Tao, B., Chen, J., Jia, S., Zhu, Z., Trudeau, V.L., Hu, W. (2017) GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish. Endocrinology. 158(4):874-886
Ai, K., Luo, K., Li, Y., Hu, W., Gao, W., Fang, L., Tian, G., Ruan, G., Xu, Q. (2017) Expression pattern analysis of IRF4 and its related genes revealed the functional differentiation of IRF4 paralogues in teleost. Fish & shellfish immunology. 60:59-64
Hu, W., Zeng, L., Wang, Y., Liu, Z., Ye, X., Li, C. (2016) A ratiometric two-photon fluorescent probe for fluoride ion imaging in living cells and zebrafish. The Analyst. 141(18):5450-5
Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
Pan, Y.X., Luo, Z., Zhuo, M.Q., Hu, W., Wu, K., Shi, X., Xu, Y.H. (2016) Liver X Receptor (LXR) in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, mRNA tissue expression and transcriptional regulation by insulin in vivo and in vitro. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 191:13-9
Zeng, L., Chen, S., Xia, T., Hu, W., Li, C., Liu, Z. (2015) Two-Photon Fluorescent Probe for Detection of Exogenous and Endogenous Hydrogen Persulfide and Polysulfide in Living Organisms. Analytical chemistry. 87(5):3004-10
Chen, R., Qi, J., Yuan, H., Wu, Y., Hu, W., Xia, C. (2015) Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces. Journal of structural biology. 189(3):259-68
Song, Y., Duan, X., Chen, J., Huang, W., Zhu, Z., Hu, W. (2015) The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain. Journal of neuroendocrinology. 27(3):198-211
Tang, H., Liu, Y., Luo, D., Ogawa, S., Yin, Y., Li, S., Zhang, Y., Hu, W., Parhar, I.S., Lin, H., Liu, X., Cheng, C.H. (2015) The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology. 156(2):589-99
Zhang, Y., Chen, J., Cui, X., Luo, D., Xia, H., Dai, J., Zhu, Z., Hu, W. (2015) A controllable on-off strategy for the reproductive containment of fish. Scientific Reports. 5:7614
Qiu, C., Cheng, B., Zhang, Y., Huang, R., Liao, L., Li, Y., Luo, D., Hu, W., Wang, Y. (2014) Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka Using TALENs. Marine biotechnology (New York, N.Y.). 16(6):674-83
Chu, L., Li, J., Liu, Y., Hu, W., Cheng, C.H. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular endocrinology (Baltimore, Md.). 28(11):1785-95
Liu, Y., Luo, D., Lei, Y., Hu, W., Zhao, H., Cheng, C.H. (2014) A highly effective TALEN-mediated approach for targeted gene disruption in Xenopus tropicalis and zebrafish. Methods (San Diego, Calif.). 69(1):58-66
Zheng, J.L., Luo, Z., Zhu, Q.L., Tan, X.Y., Chen, Q.L., Sun, L.D., and Hu, W. (2013) Molecular cloning and expression pattern of 11 genes involved in lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Gene. 531(1):53-63
Liu, Y., Luo, D., Zhao, H., Zhu, Z., Hu, W., and Cheng, C.H. (2013) Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs. PLoS One. 8(10):e76387
Chen, J., Luo, Y.S., Zhu, Z.Y., and Hu, W. (2013) Cloning and promoter analysis of gonadotrophin-releasing hormone a in the orange-spotted grouper (Epinephelus coioides). Yi chuan = Hereditas. 35(7):896-902
Cao, M., Yang, Y., Xu, H., Duan, J., Cheng, N., Wang, J., Hu, W., and Zhao, H. (2012) Germ cell specific expression of Vasa in rare minnow, Gobiocypris rarus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 162(3):163-170
Luo, D.J., Hu, W., Chen, S.P., and Zhu, Z.Y. (2011) Critical developmental stages for the efficiency of somatic cell nuclear transfer in zebrafish. International journal of biological sciences. 7(4):476-486
Guan, B., Ma, H., Wang, Y., Hu, Y., Lin, Z., Zhu, Z., and Hu, W. (2011) Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio). Marine biotechnology (New York, N.Y.). 13(2):336-44
Song, W.H., Ding, F., Guo, J., Li, L.Y., Zhang, J.H., Lian, J., Hu, W.X., and Gao, M.L. (2010) Study on acute toxicity and structure-activity relationship of zebrafish (Danio rerio) exposed to naphthoquinones. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 45(7):601-605
Xiao, Z.G., Liu, H., Fu, J.P., Hu, W., Wang, Y.P., and Guo, Q.L. (2010) Cloning of common carp SOCS-3 gene and its expression during embryogenesis, GH-transgene and viral infection. Fish & shellfish immunology. 28(2):362-371
Li, X., He, J., Hu, W., and Yin, Z. (2009) The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-2774
Ding, F., Song, W.H., Guo, J., Gao, M.L., and Hu, W.X. (2009) Oxidative stress and structure-activity relationship in the zebrafish (Danio rerio) under exposure to paclobutrazol. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 44(1):44-50
Liu, J., Sun, Y.H., Wang, Y.W., Wang, N., Pei, D.S., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology. 70(9):1525-1535
Pei, D.S., Sun, Y.H., Chen, C.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Developmental Biology. 8:29
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology. 68(9):1282-1291
Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Analytical biochemistry. 363(2):291-293
Wu, Y., Zhang, G., Xiong, Q., Luo, F., Cui, C., Hu, W., Yu, Y., Su, J., Xu, A., and Zhu, Z. (2006) Integration of Double-Fluorescence Expression Vectors into Zebrafish Genome for the Selection of Site-Directed Knockout/Knockin. Marine biotechnology (New York, N.Y.). 8(3):304-311

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