ZFIN Person: Ono, Yosuke

ZFIN ID: ZDB-PERS-100915-1

ZFIN ID: ZDB-PERS-100915-1

Ono, Yosuke

Email:	Y.Ono@exeter.ac.uk
URL:	https://lsi.exeter.ac.uk/member/dr-yosuke-ono/
Affiliation:	Scholpp Lab
Address:	Living Systems Institute, University of Exeter Stocker Road, Exeter, Devon, EX4 4QD
Country:	United Kingdom
Phone:
Fax:
ORCID ID:	0000-0002-7257-0120

BIOGRAPHY AND RESEARCH INTERESTS

2017-present Research Fellow, Living Systems Institute, University of Exeter, United Kingdom
2013-2017 Research Fellow, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
2010-2013 Research Fellow, Institute of Molecular and Cell Biology, Singapore
2007-2010 Ph.D., Graduate School of Agriculatual and Life Sciences, The University of Tokyo, Japan
2001-2007 Bachelor/Master, The University of Tokyo, Japan

Research interests:
-Muscle formation and morphogenesis
-CRISPR/Cas9-based genome editing technologies

PUBLICATIONS

Zhang, C., Brunt, L., Ono, Y., Rogers, S., Scholpp, S. (2023) Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish. Nature. 625(7993):126-133

Routledge, D., Rogers, S., Ono, Y., Brunt, L., Meniel, V., Tornillo, G., Ashktorab, H., Phesse, T., Scholpp, S. (2022) The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer. eLIFE. 11:

Winter, M.J., Ono, Y., Ball, J.S., Walentinsson, A., Michaelsson, E., Tochwin, A., Scholpp, S., Tyler, C.R., Rees, S., Hetheridge, M.J., Bohlooly-Y, M. (2022) A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation. Frontiers in pharmacology. 13:827686

Bosze, B., Ono, Y., Mattes, B., Sinner, C., Gourain, V., Thumberger, T., Tlili, S., Wittbrodt, J., Saunders, T.E., Strähle, U., Schug, A., Scholpp, S. (2020) Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish. Histochemistry and cell biology. 154(5):463-480

Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4

Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735

Ono, Y., Yu, W., Jackson, H.E., Parkin, C.A., Ingham, P.W. (2015) Adaxial cell migration in the zebrafish embryo is an active cell autonomous property that requires the Prdm1a transcription factor. Differentiation; research in biological diversity. 89(3-4):77-86

Jackson, H.E., Ono, Y., Wang, X., Elworthy, S., Cunliffe, V.T., Ingham, P.W. (2015) The role of Sox6 in zebrafish muscle fiber type specification. Skeletal muscle. 5:2

Ikeda, D., Ono, Y., Hirano, S., Kan-No, N., and Watabe, S. (2013) Lampreys have a single gene cluster for the fast skeletal Myosin heavy chain gene family. PLoS One. 8(12):e85500

Wang, X., Ono, Y., Tan, S.C., Chai, R.J., Parkin, C., and Ingham, P.W. (2011) Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo. Development (Cambridge, England). 138(20):4399-404

Yasmin, L., Kinoshita, S., Asaduzzaman, M., Akolkar, D.B., Ikeda, D., Ono, Y., and Watabe, S. (2011) A 5'-flanking region of embryonic-type myosin heavy chain gene, MYH(M743)(-)(2), from torafugu Takifugu rubripes regulates developmental muscle-specific expression. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 6(1):76-81

NON-ZEBRAFISH PUBLICATIONS
Saud, H. A., O'Neill, P. A., Ono, Y., Verbruggen, B., Van Aerle, R., Kim, J., Lee, J. S., Ring, B. C., & Kudoh, T. (2021). Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus. Development 148, dev199675.

Alshami, I. J. J., Ono, Y., Correia, A., Hacker, C., Lange, A., Scholpp, S., Kawasaki, M., Ingham, P. W. & Kudoh, T. (2020) Development of the electric organ in embryos and larvae of the knifefish, Brachyhypopomus gauderio. Developmental biology 466, 99-108.

Ono, Y., Kinoshita, S., Ikeda, D. & Watabe, S. (2010) Early development of medaka Oryzias latipes muscles as revealed by transgenic approaches using embryonic and larval types of myosin heavy chain genes. Developmental Dynamics 239, 1807-1817.

Ono, Y., Liang, C.S., Ikeda, D. & Watabe, S. (2006) cDNA cloning of myosin heavy chain genes from medaka Oryzias latipes embryos and larvae and their expression patterns during development. Developmental Dynamics 235, 3092-3101.