ZFIN ID: ZDB-PERS-100727-1
Schlegel, Amnon
Email: amnons@u2m2.utah.edu
URL: http://www.u2m2.utah.edu/labs/profiles/schlegel/schlegel.htm
Affiliation: Schlegel Lab
Address: Investigator, University of Utah Molecular Medicine (U2M2) Program Assistant Professor of Internal Medicine Adjunct Assistant Professor of Biochemistry University of Utah School of Medicine Eccles Institute of Human Genetics, Building 533, Room 3240B 15 North 2030 East Salt Lake City, UT 84112 USA
Country: United States
Phone: (801) 585-7030

My laboratory uses a forward genetic approach to identify novel genes involved in lipid metabolism. Techniques spanning multiple disciplines are used to study the identified genes.

Karanth, S., Chaurasia, B., Bowman, F.M., Tippetts, T.S., Holland, W.L., Summers, S.A., Schlegel, A. (2019) FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection. Physiological Reports. 7:e14238
Erickson, M.L., Karanth, S., Ravussin, E., Schlegel, A. (2019) FOXN3 hyperglycemic risk allele and insulin sensitivity in humans. BMJ open diabetes research & care. 7:e000688
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Flórez Salcedo, P., Smith, N.A., Smith, B.J., Schlegel, A., Forbes, B.E., Olivera, B., Hung-Chieh Chou, D., Safavi-Hemami, H. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. eLIFE. 8
Karanth, S., Schlegel, A. (2019) The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans. Frontiers in Physiology. 9:1936
Karanth, S., Adams, J.D., Serrano, M.L.A., Quittner-Strom, E.B., Simcox, J., Villanueva, C.J., Ozcan, L., Holland, W.L., Yost, H.J., Vella, A., Schlegel, A. (2018) A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Cell Reports. 24:312-319
Hugo, S.E., Schlegel, A. (2017) A genetic model to study increased hexosamine biosynthetic flux. Endocrinology. 158(8):2420-2426
Hugo, S.E., Schlegel, A. (2017) A genetic screen for zebrafish mutants with hepatic steatosis identifies a locus required for larval growth. Journal of anatomy. 230(3):407-413
Schlegel, A. (2016) Zebrafish Models for Dyslipidemia and Atherosclerosis Research. Frontiers in endocrinology. 7:159
Karanth, S., Zinkhan, E.K., Hill, J.T., Yost, H.J., Schlegel, A. (2016) FOXN3 Regulates Hepatic Glucose Utilization. Cell Reports. 15(12):2745-55
Schlegel, A., Gut, P. (2015) Metabolic insights from zebrafish genetics, physiology, and chemical biology. Cellular and molecular life sciences : CMLS. 72(12):2249-60
Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S.D., Ueberheide, B., Douglass, A.D., Schlegel, A., Imperial, J.S., Watkins, M., Bandyopadhyay, P.K., Yandell, M., Li, Q., Purcell, A.W., Norton, R.S., Ellgaard, L., Olivera, B.M. (2015) Specialized insulin is used for chemical warfare by fish-hunting cone snails.. Proceedings of the National Academy of Sciences of the United States of America. 112(6):1743-1748
Schlegel, A. (2015) Studying lipoprotein trafficking in zebrafish, the case of chylomicron retention disease. Journal of molecular medicine (Berlin, Germany). 93(2):115-8
Cruz-Garcia, L., Schlegel, A. (2014) Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. Journal of Lipid Research. 55(9):1944-58
Karanth, S., Tran, V.M., Kuberan, B., and Schlegel, A. (2013) Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Disease models & mechanisms. 6(6):1365-77
Schlegel, A. (2012) Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology. Cellular and molecular life sciences : CMLS. 69(23):3953-61
Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes & Development. 26(3):282-93
Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D., Shin, D., Chi, N.C., Shin, C.H., Schlegel, A., Halpern, M., and Stainier, D.Y. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology. 334(1):213-223
Schlegel, A., and Stainier, D.Y. (2007) Lessons from "Lower" Organisms: What Worms, Flies, and Zebrafish Can Teach Us about Human Energy Metabolism. PLoS Genetics. 3(11):e199
Schlegel, A., and Stainier, D.Y. (2006) Microsomal Triglyceride Transfer Protein Is Required for Yolk Lipid Utilization and Absorption of Dietary Lipids in Zebrafish Larvae. Biochemistry. 45(51):15179-15187