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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-090512-1
Leung, Anskar
Email: ayhleung@hku.hk
URL:
Affiliation:
Address: Room K418B K Block Department of Medicine Queen Mary Hospital Pok Fu Lam Road Hong Kong, China
Country:
Phone: 852 2855 33347
Fax: 852 2974 1165
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Leung, G.K.C., Luk, H.M., Tang, V.H.M., Gao, W.W., Mak, C.C.Y., Yu, M.H.C., Wong, W.L., Chu, Y.W.Y., Yang, W.L., Wong, W.H.S., Ma, A.C.H., Leung, A.Y.H., Jin, D.Y., Chan, K.Y.K., Allanson, J., Lo, I.F.M., Chung, B.H.Y. (2018) Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies. Scientific Reports. 8:2421
Ma, A.C.H., Shi, X., He, B.L., Guo, Y., Leung, A.Y.H. (2017) A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation. Methods in molecular biology (Clifton, N.J.). 1633:193-218
Wan, Y., Zhang, Q., Zhang, Z., Song, B., Wang, X., Zhang, Y., Jia, Q., Cheng, T., Zhu, X., Leung, A.Y., Yuan, W., Jia, H., Fang, X. (2016) Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC Medical Genomics. 9:13
Shi, X., He, B.L., Ma, A.C., Leung, A.Y. (2016) Fishing the targets of myeloid malignancies in the era of next generation sequencing. Blood reviews. 30(2):119-30
Hu, J.J., Wong, N.K., Ye, S., Chen, X., Lu, M.Y., Zhao, A.Q., Guo, Y., Ma, A.C., Leung, A.Y., Shen, J., Yang, D. (2015) Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. Journal of the American Chemical Society. 137(21):6837-43
Shi, X., He, B.L., Ma, A.C., Guo, Y., Chi, Y., Man, C.H., Zhang, W., Zhang, Y., Wen, Z., Cheng, T., Leung, A.Y. (2015) Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood. 125(19):2974-84
Warkentin, A.A., Lopez, M.S., Lasater, E.A., Lin, K., He, B., Leung, A.Y., Smith, C.C., Shah, N.P., Shokat, K.M. (2014) Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. eLIFE. 3
Song, B., Zhang, Q., Zhang, Z., Wan, Y., Jia, Q., Wang, X., Zhu, X., Leung, A.Y., Cheng, T., Fang, X., Yuan, W., Jia, H. (2014) Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency. BMC Genomics. 15:759
Guo, Y., Ma, A.C.h., He, B., Shi, X., Leung, A.Y. (2014) A novel role of ADP-ribosylation factor like 4aa(arl4aa) in zebrafish hematopoiesis. Experimental hematology. 42:S36
Shi, X., He, B., Ma, A.C.h., Guo, Y., Leung, A.Y. (2014) Functions of IDH1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Experimental hematology. 42:S59
He, B.L., Shi, X., Man, C.H., Ma, A.C., Ekker, S.C., Chow, H.C., So, C.W., Choi, W.W., Zhang, W., Zhang, Y., and Leung, A.Y. (2014) Functions of FMS-like tyrosine kinase 3 (flt3) in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 123(16):2518-29
Bedell, V.M., Wang, Y., Campbell, J.M., Poshusta, T.L., Starker, C.G., Krug, R.G., Tan, W., Penheiter, S.G., Ma, A.C., Leung, A.Y., Fahrenkrug, S.C., Carlson, D.F., Voytas, D.F., Clark, K.J., Essner, J.J., and Ekker, S.C. (2012) In vivo genome editing using a high-efficiency TALEN system. Nature. 491(7422):114-118
Xiao, S.M., Kung, A.W., Gao, Y., Lau, K.S., Ma, A., Zhang, Z.L., Liu, J.M., Xia, W., He, J.W., Zhao, L., Nie, M., Fu, W.Z., Zhang, M.J., Sun, J., Kwan, J.S., Tso, G.H., Dai, Z.J., Cheung, C.L., Bow, C.H., Leung, A.Y., Tan, K.C., and Sham, P.C. (2012) Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density. Human molecular genetics. 21(7):1648-1657
Tse, H.Y., Hui, M.N., Li, L., Lee, S.M., Leung, A.Y., and Cheng, S.H. (2012) Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. Journal of ethnopharmacology. 139(2):447-53
Ma, A.C., Fung, T.K., Lin, R.H., Chung, M.I., Yang, D., Ekker, S.C., and Leung, A.Y. (2011) Methionine aminopeptidase 2 is required for HSC initiation and proliferation. Blood. 118(20):5448-57
Chung, M.I., Ma, A.C., Fung, T.K., and Leung, A.Y. (2011) Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis. Experimental hematology. 39(10):986-998.e5
Fung, T.K., Chung, M.I., Liang, R., and Leung, A.Y. (2010) The role of a novel zebrafish nup98 during embryonic development. Experimental hematology. 38(11):1014-1021.e1-2
Ma, A.C., Fan, A., Ward, A.C., Liongue, C., Lewis, R.S., Cheng, S.H., Chan, P.K., Yip, S.F., Liang, R., and Leung, A.Y. (2009) A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Experimental hematology. 37(12):1379-1386
Ma, A.C., Chung, M.I., Liang, R., and Leung, A.Y. (2009) The role of survivin2 in primitive hematopoiesis during zebrafish development. Leukemia. 23(4):712-720
Lam, H.W., Lin, H.C., Lao, S.C., Gao, J.L., Hong, S.J., Leong, C.W., Yue, P.Y., Kwan, Y.W., Leung, A.Y., Wang, Y.T., and Lee, S.M. (2008) The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. Journal of cellular biochemistry. 103(1):195-211
Ma, A.C., Ward, A.C., Liang, R., and Leung, A.Y. (2007) The role of jak2a in zebrafish hematopoiesis. Blood. 110(6):1824-1830
Ma, A.C., Lin, R., Chan, P.K., Leung, J.C., Chan, L.Y., Meng, A., Verfaillie, C.M., Liang, R., and Leung, A.Y. (2007) The role of survivin in angiogenesis during zebrafish embryonic development. BMC Developmental Biology. 7(1):50
Ma, A.C., Liang, R., and Leung, A.Y. (2007) The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development. Experimental hematology. 35(3):368-373
Kwan, T.T., Liang, R., Verfaillie, C.M., Ekker, S.C., Chan, L.C., Lin, S., and Leung, A.Y. (2006) Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene. Experimental hematology. 34(1):27-34
Leung, A.Y., Leung, J.C., Chan, L.Y., Ma, E.S., Kwan, T.T., Lai, K., Meng, A., and Liang, R. (2005) Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis. Histochemistry and cell biology. 124(2):105-111
Leung, A.Y., Mendenhall, E.M., Kwan, T.T., Liang, R., Eckfeldt, C., Chen, E., Hammerschmidt, M., Grindley, S., Ekker, S.C., and Verfaillie, C.M. (2005) Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Developmental Biology. 277(1):235-254

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