ZFIN ID: ZDB-PERS-090317-2
Mathuru, Ajay
Email: ajay.mathuru@yale-nus.edu.sg
URL: https://www.yale-nus.edu.sg/about/faculty/ajay-s-mathuru/
Affiliation: Mathuru Lab
Address: NATIONAL UNIVERSITY OF SINGAPORE Yale-NUS College E6, 5 Engineering Drive 1, #04-01B 117608
Country: Singapore
Phone: +65 66015312
Fax:
ORCID ID: 0000-0003-4591-5274


BIOGRAPHY AND RESEARCH INTERESTS
Ajay Mathuru was born in Nagpur, India. His scientific career started in Prof. Obaid Siddiqi's lab, as a member of the visiting students research program (VSRP) at TIFR, Mumbai, India. He went to graduate school at the National Center for Biological Sciences (NCBS), Bangalore, India where he completed Ph.D. training with Prof. Upi Bhalla. He moved to Singapore in 2006 as a postdoctoral fellow in the Jesuthasan lab in Singapore first at TLL, then at NRP, and IMCB, A*STAR. He holds joint appointments with Yale-NUS College as Assistant Professor of Science, and as Joint Principal Investigator at IMCB, A*STAR, Singapore since 2015.


PUBLICATIONS
Kaur, P., Kibat, C., Teo, E., Gruber, J., Mathuru, A., Tolwinski, A.N.S. (2020) Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in Drosophila melanogaster, Danio rerio and Caenorhabditis elegans. Bio-protocol. 10:e3856
Koh, A., Tao, S., Jing, G.Y., Chaganty, V., See, K., Purushothaman, K., Orbán, L., Mathuru, A.S., Wohland, T., Winkler, C. (2020) A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish. Human molecular genetics. 29(23):3765-3780
Lim, C.H., Kaur, P., Teo, E., Lam, V.Y.M., Zhu, F., Kibat, C., Gruber, J., Mathuru, A.S., Tolwinski, N.S. (2020) Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration. eLIFE. 9:
Hengel, H., Bosso-Lefèvre, C., Grady, G., Szenker-Ravi, E., Li, H., Pierce, S., Lebigot, É., Tan, T.T., Eio, M.Y., Narayanan, G., Utami, K.H., Yau, M., Handal, N., Deigendesch, W., Keimer, R., Marzouqa, H.M., Gunay-Aygun, M., Muriello, M.J., Verhelst, H., Weckhuysen, S., Mahida, S., Naidu, S., Thomas, T.G., Lim, J.Y., Tan, E.S., Haye, D., Willemsen, M.A.A.P., Oegema, R., Mitchell, W.G., Pierson, T.M., Andrews, M.V., Willing, M.C., Rodan, L.H., Barakat, T.S., van Slegtenhorst, M., Gavrilova, R.H., Martinelli, D., Gilboa, T., Tamim, A.M., Hashem, M.O., AlSayed, M.D., Abdulrahim, M.M., Al-Owain, M., Awaji, A., Mahmoud, A.A.H., Faqeih, E.A., Asmari, A.A., Algain, S.M., Jad, L.A., Aldhalaan, H.M., Helbig, I., Koolen, D.A., Riess, A., Kraegeloh-Mann, I., Bauer, P., Gulsuner, S., Stamberger, H., Ng, A.Y.J., Tang, S., Tohari, S., Keren, B., Schultz-Rogers, L.E., Klee, E.W., Barresi, S., Tartaglia, M., Mor-Shaked, H., Maddirevula, S., Begtrup, A., Telegrafi, A., Pfundt, R., Schüle, R., Ciruna, B., Bonnard, C., Pouladi, M.A., Stewart, J.C., Claridge-Chang, A., Lefeber, D.J., Alkuraya, F.S., Mathuru, A.S., Venkatesh, B., Barycki, J.J., Simpson, M.A., Jamuar, S.S., Schöls, L., Reversade, B. (2020) Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nature communications. 11:595
Haghani, S., Karia, M., Cheng, R.K., Mathuru, A.S. (2019) An Automated Assay System to Study Novel Tank Induced Anxiety. Frontiers in behavioral neuroscience. 13:180
Lim, C.H., Mathuru, A.S. (2017) Modeling Alzheimer's and Other Age Related Human Diseases in Embryonic Systems. Journal of developmental biology. 6(1)
Mathuru, A.S. (2016) Conspecific injury raises an alarm in medaka. Scientific Reports. 6:36615
Krishnan, S., Mathuru, A.S., Kibat, C., Rahman, M., Lupton, C.E., Stewart, J., Claridge-Chang, A., Yen, S.C., Jesuthasan, S. (2014) The Right Dorsal Habenula Limits Attraction to an Odor in Zebrafish. Current biology : CB. 24(11):1167-75
Schirmer, A., Jesuthasan, S., and Mathuru, A.S. (2013) Tactile stimulation reduces fear in fish. Frontiers in behavioral neuroscience. 7:167
Tan, S.J., Kee, M.Z., Mathuru, A.S., Burkholder, W.F., and Jesuthasan, S.J. (2013) A microfluidic device to sort cells based on dynamic response to a stimulus. PLoS One. 8(11):e78261
Mathuru, A.S., and Jesuthasan, S. (2013) The medial habenula as a regulator of anxiety in adult zebrafish. Frontiers in neural circuits. 7:99
Mathuru, A.S., Kibat, C., Cheong, W.F., Shui, G., Wenk, M.R., Friedrich, R.W., and Jesuthasan, S. (2012) Chondroitin fragments are odorants that trigger fear behavior in fish. Current biology : CB. 22(6):538-544
Lee, A., Mathuru, A.S., Teh, C., Kibat, C., Korzh, V., Penney, T.B., and Jesuthasan, S. (2010) The habenula prevents helpless behavior in larval zebrafish. Current biology : CB. 20(24):2211-2216

NON-ZEBRAFISH PUBLICATIONS