ZFIN ID: ZDB-PERS-090127-1
Galindo-Villegas, Jorge
Email: jorge.galindo-villegas@nord.no; jorge-galindo@usa.net
URL: http://www.nord.no
Address: Principal Investigator Department of Genomics Faculty of Biosciences and Aquaculture Nord University Universitetsalléen 11 8026 Bodø NORWAY
Phone: +4775517048
Fax: +4775517349
ORCID ID: 0000-0002-4250-2477

Current research is focused on the study of the unique complex relationships between the host and the microbiota and understand the foundations of innate immunity. Particularly, I use the germ-free model in transgenic fish analyzed through live-imaging, molecular, and genomic techniques.

Bastos, T.S.B., de Paula, A.G.P., Dos Santos Luz, R.B., Garnique, A.M.B., Belo, M.A.A., Eto, S.F., Fernandes, D.C., Ferraris, F.K., de Pontes, L.G., França, T.T., Barcellos, L.J.G., Veras, F.P., Bermejo, P., Guidelli, G., Maneira, C., da Silveira Bezerra de Mello, F., Teixeira, G., Pereira, G.A.G., Fernandes, B.H.V., Sanches, P.R.S., Braz, H.L.B., Jorge, R.J.B., Malafaia, G., Cilli, E.M., Olivier, D.D.S., do Amaral, M.S., Medeiros, R.J., Condino-Neto, A., Carvalho, L.R., Machado-Santelli, G.M., Charlie-Silva, I., Galindo-Villegas, J., Braga, T.T. (2023) A novel insight on SARS-CoV-2 S-derived fragments in the control of the host immunity. Scientific Reports. 13:80608060
Rosa, I.F., Peçanha, A.P.B., Carvalho, T.R.B., Alexandre, L.S., Ferreira, V.G., Doretto, L.B., Souza, B.M., Nakajima, R.T., da Silva, P., Barbosa, A.P., Gomes-de-Pontes, L., Bomfim, C.G., Machado-Santelli, G.M., Condino-Neto, A., Guzzo, C.R., Peron, J.P.S., Andrade-Silva, M., Câmara, N.O.S., Garnique, A.M.B., Medeiros, R.J., Ferraris, F.K., Barcellos, L.J.G., Correia-Junior, J.D., Galindo-Villegas, J., Machado, M.F.R., Castoldi, A., Oliveira, S.L., Costa, C.C., Belo, M.A.A., Galdino, G., Sgro, G.G., Bueno, N.F., Eto, S.F., Veras, F.P., Fernandes, B.H.V., Sanches, P.R.S., Cilli, E.M., Malafaia, G., Nóbrega, R.H., Garcez, A.S., Carrilho, E., Charlie-Silva, I. (2023) Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model. International Journal of Molecular Sciences. 24(7):
Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
Ventura Fernandes, B.H., Feitosa, N.M., Barbosa, A.P., Bomfim, C.G., Garnique, A.M.B., Rosa, I.F., Rodrigues, M.S., Doretto, L.B., Costa, D.F., Santos, B.C., Franco, G.A., Neto, J.F., Lunardi, J.S., Bellot, M.S., Alves, N.P.C., Costa, C.C., Aracati, M.F., Rodrigues, L.F., Costa, C.C., Cirilo, R.H., Colagrande, R.M., Gomes, F.I.F., Nakajima, R.T., Belo, M.A.A., Giaquinto, P.C., de Oliveira, S.L., Eto, S.F., Fernandes, D.C., Manrique, W.G., Conde, G., Rosales, R.R.C., Todeschini, I., Rivero, I., Llontop, E., Sgro, G.G., Oka, G.U., Bueno, N.F., Ferraris, F.K., de Magalhães, M.T.Q., Medeiros, R.J., Gomes, J.M.M., Junqueira, M.S., Conceição, K., Pontes, L.G., Neto, A.C., Perez, A.C., Barcellos, L.G., Júnior, J.D.C., Dorlass, E.G., Camara, N.O.S., Durigon, E.L., Cunha, F.Q., Nóbrega, R.H., Machado-Santelli, G.M., Farah, C.S., Veras, F.P., Galindo-Villegas, J., Costa-Lotufo, L.V., Cunha, T.M., Chammas, R., Carvalho, L.R., Guzzo, C.R., Malafaia, G., Charlie-Silva, I. (2021) Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?. The Science of the total environment. 813:152345
Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron,V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978
Galindo-Villegas, J. (2020) The Zebrafish Disease and Drug Screening Model: A Strong Ally Against Covid-19. Frontiers in pharmacology. 11:680
Sepahi, A., Kraus, A., Casadei, E., Johnston, C.A., Galindo-Villegas, J., Kelly, C., García-Moreno, D., Muñoz, P., Mulero, V., Huertas, M., Salinas, I. (2019) Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 116(25):12428-12436
Martínez-Navarro, F.J., Martínez-Menchón, T., Mulero, V., Galindo-Villegas, J. (2019) Models of human psoriasis: Zebrafish the newly appointed player. Developmental and comparative immunology. 97:76-87
Siriyappagouder, P., Galindo-Villegas, J., Lokesh, J., Mulero, V., Fernandes, J., and Kiron, V. (2018) Exposure to Yeast Shapes the Intestinal Bacterial Community Assembly in Zebrafish Larvae. Frontiers in microbiology. 9:1868
Galindo-Villegas, J., Montalban-Arques, A., Liarte, S., de Oliveira, S., Pardo-Pastor, C., Rubio-Moscardo, F., Meseguer, J., Valverde, M.A., Mulero, V. (2016) TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity. Journal of immunology (Baltimore, Md. : 1950). 196(2):738-49
Galindo-Villegas, J. (2016) Recent findings on vertebrate developmental immunity using the zebrafish model. Molecular immunology. 69:106-12
de Oliveira, S., Lopez-Muñoz, A., Martínez-Navarro, F.J., Galindo-Villegas, J., Mulero, V., Calado, A. (2015) Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium. Developmental and comparative immunology. 49:44-48
Galindo-Villegas, J., García-Moreno, D., de Oliveira, S., Meseguer, J., and Mulero, V. (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 109(39):E2605-2614

Montero D, Torrecillas S, Acosta F, Galindo-Villegas J. Phytogenics enhance the welfare and vaccine efficacy against Vibrio anguillarum in European seabass (Dicentrarchus labrax) juveniles. 2024. Aquaculture In press.

Figueras A, Wang L-L, MacKenzie S, Galindo-Villegas J. Exploring the Health of Aquatic Organisms Trough an Immune Viewpoint. 2024. Front. Immunol. 16,

Passantino L, Corriero A, Pousis C, Zupa R, Perillo A, Superio J, Kumari Swain J, Foss A, Galindo-Villegas J, Ventriglia G. Hepatic melanomacrophage centers in the arctic cultured fish Cyclopterus lumpus are not indicative of its health state. 2024. Aquaculture 740417.

Laceta J, Galindo-Villegas J. Overcoming challenges in mucosal immunity. 2023. Front. Immunol. 14, 1327091

Acosta F, Vega B, Superio J, Torrecillas S, Montero D, Galindo-Villegas J. Phylogenetic reconstruction, histopathological characterization, and virulence determination of a novel fish pathogen, Nocardia brasiliensis. 2023. Aquaculture 740458.

Sharko F, Rbbani G, Siriyappagouder P, Raeymaekers J, Galindo‑Villegas J, Nedoluzhko A, Fernandes J. CircPrime: a web‑based platform for the design of specific circular RNA primers. 2023. BMC Bioinformatics 05331.

Rbbani G, Nedoluzhko A, Siriyappagouder P, Sharko F, Galindo-Villegas J, Raeymaekers J, Joshi R, Fernandes J. The novel circular RNA CircMef2c is positively associated with muscle growth in Nile tilapia. 2023. Genomics 110598.

Nedoluzhko A, Orlova SY, Kurnosov DS, Orlov AM, Galindo-Villegas J, Rastorguev S. Genomic Signatures of Freshwater Adaptation in Pacific Herring (Clupea pallasii). 2022. Genes 13, 10:1856.

Nedoluzhko A, Sharko F, Tsygankova S, Boulygina E, Slovodoba N, Teslyuk A, Galindo-Villegas J, Rastorguev S. Intergeneric Hybridization of Two Stickleback Species Leads to Introgression of Membrane-Associated Genes and Invasive TE Expansion. 2022. Front. Genet. 13:863547.

Monzón-Atienza L, Bravo J, Montero D, Charlie-Silva, I, Ramos‑Vivas J, Galindo‑Villegas J, Acosta F. Dietary supplementation of Bacillus velezensis improves Vibrio anguillarum clearance in European sea bass by activating essential innate immune mechanisms. Fish and Shellfish Immunol. 2022. 124:244-253.

F Acosta, J Bravo, L Monzón-Atienza, J Galindo-Villegas, S Torecillas, D Montero. Peracetic acid can be used as a disinfectant for gilthead sea bream (Sparus aurata) juveniles without affecting fish welfare. Aquaculture Reports. 2022. 24:101107

Galindo-Villegas, Jorge, Reyes-Lopez Felipe, Peter Bossier. Oral Immune-Enhancing Research in Fish. 2022. Front. Immunol. 13:850026.

Castejón P, Cabas I, Gómez V, Chaves-Pozo E, Cerezo-Ortega I, Moriñigo MÁ, Martínez-Manzanares E, Galindo-Villegas J, García-Ayala A. “Vaccination of gilthead seabream after continuous xenoestrogen oral exposure enhances the gut endobolome and immune status via GPER1” 2021. Front. Immunol. 12:742827.

Rbbani, Md Golam; Nedoluzhko, Artem; Galindo-Villegas, Jorge; Fernandes, Jorge Manuel de Oliveira. Function of Circular RNAs in Fish and Their Potential Application as Biomarkers. 2021. Int. J. Mol. Sci. 22(13) p. 1-19

Charlie-Silva, Ives; Araújo, Amanda P.C.; Abraão T.B., Guimarães; Helyson L.B., Braz; Letícia G., de Pontes; Marco A.A., Belo; Galindo-Villegas, Jorge; Guilherme, Malafaia. Toxicological insights of spike fragments SARS-Cov-2 by exposure environment: A threat to aquatic health?. J. Hazard. Mat. 2021 (126463), 1-36

Firmino JP, Galindo-Villegas J,Reyes-Lopez FE and Gisbert E (2021). Phytogenic Bioactive Compounds Shape Fish Mucosal Immunity. Front. Immunol. 12:695973.

Monzón-Atienza L, Bravo J, Torrecillas S, Montero D, González‑de Canales A.F, García de la Banda I, Galindo‑Villegas J, Ramos‑Vivas J, Acosta F. (2021) Isolation and Characterization of a Bacillus velezensis D-18 Strain, as a Potential Probiotic in European Seabass Aquaculture" Probiotics & Antimicro. Prot. https://doi.org/10.1007/s12602-021-09782-8

Ramos-Vivas J, Superio J, Galindo-Villegas J, Acosta F. “Phage therapy as a focused management strategy in aquaculture” 2021 Int. J. of Mol. Sci. 22(19), 10436

Nedoluzhko A, Sharko F, Tsygankova S, Boulygina E, Ibragimova A, Teslyuk A, Galindo-Villegas J, Rastorguev S. Genomic evidence supports the introgression between two sympatric stickleback species inhabiting the White Sea basin. Heliyon, (2021). 7(2):e06160

López-Cánovas A, Cabas I, Chavez-Pozo E, López A, Fernandes JMO, García-Ayala A, Galindo-Villegas J. “Nanoencapsulated clove essential oil applied as an anesthetic at slaughtering, decreases stress, extends the freshness and lengthens shell life of cultured fish” Foods 2020. 9(12):1750

Acosta, F, Izquierdo, M, Montero, D, Galindo-Villegas, J. “High-Level Biocidal Products Effectively Eradicate Pathogenic γ-Proteobacteria Biofilms from Aquaculture Facilities”. Aquaculture 2020. 532:766004

Galindo-Villegas J, Garcia-Alcazar A, Mulero V. “Aluminum adjuvant potentiates gilthead seabream immune responses but induces toxicity in splenic melanomacrophage centers”. Special Issue at Fish and Shellfish Immunol. 2019. 85, (31-43).

Sepahi A, Kraus A, Galindo-Villegas J, Kelly C, Garcia-Moreno D, Mulero V, Huertas MM, Salinas I. “The immunological role of crypt olfactory neurons against neurotropic viruses in teleost fish”. J. Immunol. 2018. 200, 1 supp. 173.15.

Mweemba Munang’andu H, Galindo-Villegas J and David L. “Teleost genomics: Progress and prospects in disease prevention and control”. Int. J. of Mol. Sci. 2018. 19, 1083.

Piazzon MC, Galindo-Villegas J, Pereiro P, Estensoro I, Calduch-Giner JA, Gómez-Casado E, Novoa B, Mulero V, Sitjà-Bobadilla A, Pérez-Sánchez J. “Differential Modulation of IgT and IgM upon Parasitic, Bacterial, Viral, and Dietary Challenges in a Perciform Fish”. Front. Immunol. 2016. 7:637.

Galindo-Villegas J, Garcia-Garcia E, Mulero V. Role of histamine in regulating intestinal immunity in fish. Dev. Comp. Immunol. 2016. 64, (178-186)

Montalban-Arques A, De Schryver P, Bossier P, Gorkiewicz G, Mulero V, Gatlin III DM and Galindo-Villegas J “Selective manipulation of the gut microbiota improves immune status in vertebrates”. Frontiers in Immunol. 6:512.

Montero J, Gómez-Casado E, García Alcázar A, Meseguer J, Galindo-Villegas J, Mulero V. “Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream” Fish and Shellfish Immunol. 2014, 37(5), 456-463.

Montalban-Arques A, Gorkiewickz G, Mulero V, Galindo-Villegas J. “Cytokine Intervention: A Double-Edged Sword in NKG2D System Regulation” Immunome Res. 2014, (10), S2. S3:1-13.

Galindo-Villegas J, Mulero V. “Are oil-in-water-adjuvants worth to be applied in seabream farming?” Fish and Shellfish Immunol. 2013, 34(6), 1635 – 1691.

Montero J, Gomez-Casado E, Galindo-Villegas J, Coll J, Meseguer J, Mulero V. “Comparative study of the immunological properties of three flagellins in gilthead seabream” Fish and Shellfish Immunol. 2013, 34(6), 1635 – 1691.

Baruah K, Nan B, Norouzitallab P, Dierckens K, Galindo-Villegas J, Bossier P. “Priming in host-pathogen interactions” Fish and Shellfish Immunol. 2013, 34(6), 1635 – 1691.

Galindo-Villegas J, Mulero I, Garcia-Alcazar A, Munoz I, Penalver-Mellado M, Streitenberg S, Scapigliati G, Mulero V. “Recombinant TNFa as oral vaccine adjuvant protects European sea bass against vibriosis: Insights into the role of the CCL25/CCR9 axis” Fish and Shellfish Immunol. 2013 (35):1260-1271.

Garcia-Garcia E, Galindo-Villegas J, Mulero V. Mucosal Immunity in the gut: The non-vertebrate perspective. Dev. Comp. Immunol. 2013, (40):278-288.

Vadstein O, Bergh Ø, Gatesoupe F-J, Galindo-Villegas J, Mulero V, Picchietti S, Scapigliati G, Makridis P, Olsen Y, Dierckens K, Defoirdt T, Boon N, De Schryver P, Bossier P. “Microbiology and immunology of fish larvae”. (2012) Rev. Aqua. 4, 1-25.

Sarropouloua E, Galindo-Villegas J, Garcia-Alcazar A, Kasapidisa P, Mulero V. “Characterization of European Sea Bass transcripts by RNA SEQ after Oral Vaccine against V. anguillarum”. (2012) Mar. Bio. Tech. 14:634-642.

Galindo-Villegas J, Fukada H, Masumoto T, Hosokawa H. “Dietary intake of peptidoglycan strongly enhances the innate immune response and increases disease resistance against Edwardsiella tarda in Japanese flounder Paralichthys olivaceus (Temminck& Schlegel)” Fish Shellfish Immunol. (Stack).

Galindo-Villegas J, Masumoto T, Hosokawa H. “Effects of continuous and interval administration of peptidoglycan on innate immune response and disease resistance in Japanese flounder Paralichthys olivaceus”. (2006) Aquaculture Sci. 54(1), 153-162.

Galindo-Villegas J. “Dietary supplementation of autolyzed brewer’s yeast for health management of Japanese flounder Paralichthys olivaceus”. (2006) Aquafeeds: Formulations & Beyond 2(3): 15-17.

Galindo-Villegas J, Fukada H, Masumoto T, Hosokawa H. “Effect of dietary immunostimulants on some innate immune responses and disease resistance against Edwardsiella tarda infection in Japanese flounder (Paralichthys olivaceus)”. (2006) Aquaculture Sci. 54(2), 163-170.

Galindo-Villegas J Hosokawa H. “Effects of commercial yeast extract preparation on innate immune response and disease resistance of Japanese flounder (Paralichthys olivaceus)”. (2005) EAS Special Pub. 35, 213-214.

Galindo-Villegas J, Hosokawa H. “Immunostimulants in marine fish diets”. (2005) Intl. Aquafeed. 8(3): 30-39.

Caceres BM, Masumoto T, Galindo-Villegas J, Hosokawa H. “Effect of levamisole by oral administration on the innate immune response of juvenile Japanese flounder (Paralichthys olivaceus)”. (2004) CIVA. 625-634.

Galindo-Villegas J, Sosa-Lima F. (2002) Gonopodial system review and a new fish record of Poeciliopsis infans (Cyprinodontiformes: Poeciliidae) for Lake Patzcuaro, Michoacan, central Mexico. Trop. Biol. 50(3/4): 1151-1157.

Galindo-Villegas J, Gamboa JA, Dreckmann KM. (1997) Study of the seaweeds of Salina Cruz, Oaxaca; Rediscovery of Predadea subpeltataand new record of Cryptonemia angustata for the Tehuantepec Gulf, Mexican Tropical Pacific Ocean. Polibot. (4):1-9.