ZFIN ID: ZDB-PERS-080819-1
Wang, Guangliang (Johnny)
Email: guangliang.wang@novartis.com
Affiliation: Guangliang (Johnny) Wang Lab
Address: Novartis Institutes for BioMedical Research Floor7, 181 Massachusetts Avenue Cambridge, MA 02139
Country: United States
Phone: 617-871-5146

Drug discovery using the zebrafish model

Singh, A.P., Sosa, M.X., Fang, J., Shanmukhappa, S.K., Hubaud, A., Fawcett, C.H., Molind, G.J., Tsai, T., Capodieci, P., Wetzel, K., Sanchez, E., Wang, G., Coble, M., Tang, W., Cadena, S.M., Fishman, M.C., Glass, D.J. (2019) αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish. Cell Reports. 28:2767-2776.e5
Wang, G., Zhang, G., Li, Z., Fawcett, C.H., Coble, M., Sosa, M.X., Tsai, T., Malesky, K., Thibodeaux, S.J., Zhu, P., Glass, D.J., Fishman, M.C. (2019) Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine. iScience. 17:325-333
Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
Huang, W., Beer, R.L., Delaspre, F., Wang, G., Edelman, H.E., Park, H., Azuma, M., Parsons, M.J. (2016) Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Developmental Biology. 418(1):28-39
Delaspre, F., Beer, R.L., Rovira, M., Huang, W., Wang, G., Gee, S., Vitery, M.D., Wheelan, S.J., Parsons, M.J. (2015) Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration. Diabetes. 64(10):3499-509
Wang, G., Rajpurohit, S.K., Delaspre, F., Walker, S.L., White, D.T., Ceasrine, A., Kuruvilla, R., Li, R.J., Shim, J.S., Liu, J.O., Parsons, M.J., Mumm, J.S. (2015) First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. eLIFE. 4
Huang, W., Wang, G., Delaspre, F., Vitery, M.D., Beer, R.L., Parsons, M.J. (2014) Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Developmental Biology. 394(1):83-93
Maragh, S., Miller, R.A., Bessling, S.L., Wang, G., Hook, P.W., McCallion, A.S. (2014) Rbm24a and Rbm24b Are Required for Normal Somitogenesis. PLoS One. 9:e105460
Wang, G., Yost, H.J., and Amack, J.D. (2013) Analysis of Gene Function and Visualization of Cilia-Generated Fluid Flow in Kupffer's Vesicle. Journal of visualized experiments : JoVE. (73)
Wang, G., Manning, M.L., and Amack, J.D. (2012) Regional Cell Shape Changes Control Form and Function of Kupffer's Vesicle in the Zebrafish Embryo. Developmental Biology. 370(1):52-62
French, V.M., van de Laar, I.M., Wessels, M.W., Rohe, C., Roos-Hesselink, J.W., Wang, G., Frohn-Mulder, I.M., Severijnen, L.A., de Graaf, B.M., Schot, R., Breedveld, G., Mientjes, E., van Tienhoven, M., Jadot, E., Jiang, Z., Verkerk, A., Swagemakers, S., Venselaar, H., Rahimi, Z., Najmabadi, H., Meijers-Heijboer, H., de Graaff, E., Helbing, W.A., Willemsen, R., Devriendt, K., Belmont, J.W., Oostra, B.A., Amack, J.D., and Bertoli-Avella, A.M. (2012) NPHP4 Variants Are Associated With Pleiotropic Heart Malformations. Circulation research. 110(12):1564-1574
Wang, G., Cadwallader, A.B., Jang, D.S., Tsang, M., Yost, H.J., and Amack, J.D. (2011) The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (Cambridge, England). 138(1):45-54
Gao, C., Wang, G., Amack, J.D., and Mitchell, D.R. (2010) Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(8):2190-2197