ZFIN Person: Bitter, Wilbert

ZFIN ID: ZDB-PERS-070501-2

Bitter, Wilbert

Email:	w.bitter@vumc.nl
URL:
Affiliation:	Van der Sar Lab
Address:	VU university medical center Dept. Medical Microbiology and Infection control Van der Boechorststraat 7 Amsterdam, 1081 BT Netherlands
Country:	Netherlands
Phone:	+31 20 4448318
Fax:	+31 20 4448319
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

van Alen, I., Aguirre García, M.A., Maaskant, J.J., Kuijl, C.P., Bitter, W., Meijer, A.H., Ubbink, M. (2023) Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis. Scientific Reports. 13:1540615406

Otero-Asman, J.R., Sánchez-Jiménez, A., Bastiaansen, K.C., Wettstadt, S., Civantos, C., García-Puente, A., Bitter, W., Llamas, M.A. (2023) The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa. iScience. 26:107216107216

Ho, V.Q.T., Rong, M.K., Habjan, E., Bommer, S.D., Pham, T.V., Piersma, S.R., Bitter, W., Ruijter, E., Speer, A. (2023) Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles. Biomolecules. 13(2):

Jim, K.K., Aprianto, R., Koning, R., Domenech, A., Kurushima, J., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Bitter, W., Veening, J.W. (2022) Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq. Cell Reports. 41:111851111851

Schouten, G.K., Paulussen, F.M., Kuipers, O.P., Bitter, W., Grossmann, T.N., van Ulsen, P. (2022) Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo. Antibiotics (Basel, Switzerland). 11(2):

Habjan, E., Ho, V.Q.T., Gallant, J., Van Stempvoort, G., Jim, K.K., Kuijl, C., Geerke, D.P., Bitter, W., Speer, A. (2021) Anti-tuberculosis Compound Screen using a Zebrafish Infection Model identifies an Aspartyl-tRNA Synthetase Inhibitor. Disease models & mechanisms. 14(12):

van der Niet, S., van Zon, M., de Punder, K., Grootemaat, A., Rutten, S., Moorlag, S.J.C.F.M., Houben, D., van der Sar, A.M., Bitter, W., Brosch, R., Hernandez Pando, R., Pena, M.T., Peters, P.J., Reits, E.A., Mayer-Barber, K.D., van der Wel, N.N. (2021) IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo. mSphere. 6(3):

Ho, V.Q.T., Verboom, T., Rong, M.K., Habjan, E., Bitter, W., Speer, A. (2021) Heterologous expression of ethA and katG in Mycobacterium marinum enables the rapid identification of new prodrugs active against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 65(4):

Commandeur, S., Iakobachvili, N., Sparrius, M., Nur, M.M., Mukamolova, G.V., Bitter, W. (2020) A zebrafish embryo model for assessment of drug efficacy on mycobacterial persisters. Antimicrobial Agents and Chemotherapy. 64(10):

Otero-Asman, J.R., Quesada, J.M., Jim, K.K., Ocampo-Sosa, A., Civantos, C., Bitter, W., Llamas, M.A. (2020) The extracytoplasmic function sigma factor σ^VreI is active during infection and contributes to phosphate starvation-induced virulence of Pseudomonas aeruginosa. Scientific Reports. 10:3139

Burggraaf, M.J., Speer, A., Meijers, A.S., Ummels, R., van der Sar, A.M., Korotkov, K.V., Bitter, W., Kuijl, C. (2019) Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease. mBio. 10(5):

Phan, T.H., van Leeuwen, L.M., Kuijl, C., Ummels, R., van Stempvoort, G., Rubio-Canalejas, A., Piersma, S.R., Jiménez, C.R., van der Sar, A.M., Houben, E.N.G., Bitter, W. (2018) EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF. PLoS pathogens. 14:e1007247

van Leeuwen, L.M., Boot, M., Kuijl, C., Picavet, D.I., van den Brink, G., van der Pol, S.M.A., de Vries, H.E., van der Wel, N.N., van der Kuip, M., van Furth, A.M., van der Sar, A.M., Bitter, W. (2018) Mycobacteria employ two different mechanisms to cross the blood-brain barrier. Cellular Microbiology. 20(9):e12858

Boot, M., Jim, K.K., Liu, T., Commandeur, S., Lu, P., Verboom, T., Lill, H., Bitter, W., Bald, D. (2017) A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection. Scientific Reports. 7:10665

Jim, K.K., Engelen-Lee, J., van der Sar, A.M., Bitter, W., Brouwer, M.C., van der Ende, A., Veening, J.W., van de Beek, D., Vandenbroucke-Grauls, C.M. (2016) Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model. Journal of neuroinflammation. 13:188

Ates, L.S., van der Woude, A.D., Bestebroer, J., van Stempvoort, G., Musters, R.J., Garcia-Vallejo, J.J., Picavet, D.I., Weerd, R.V., Maletta, M., Kuijl, C.P., van der Wel, N.N., Bitter, W. (2016) The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10. PLoS pathogens. 12:e1005696

van de Weerd, R., Boot, M., Maaskant, J., Sparrius, M., Verboom, T., van Leeuwen, L.M., Burggraaf, M.J., Paauw, N.J., Dainese, E., Manganelli, R., Bitter, W., Appelmelk, B.J., Geurtsen, J. (2016) Inorganic phosphate limitation modulates capsular polysaccharide composition in mycobacteria. The Journal of biological chemistry. 291(22):11787-99

van Leeuwen, L.M., van der Sar, A.M., Bitter, W. (2014) Animal Models of Tuberculosis: Zebrafish. Cold Spring Harbor Perspectives in Medicine. 5(3):a018580

van Leeuwen, L.M., van der Kuip, M., Youssef, S.A., de Bruin, A., Bitter, W., van Furth, A.M., van der Sar, A.M. (2014) Modelling tuberculous meningitis in zebrafish using Mycobacterium marinum. Disease models & mechanisms. 7(9):1111-22

Makarov, V., Lechartier, B., Zhang, M., Neres, J., van der Sar, A.M., Raadsen, S.A., Hartkoorn, R.C., Ryabova, O.B., Vocat, A., Decosterd, L.A., Widmer, N., Buclin, T., Bitter, W., Andries, K., Pojer, F., Dyson, P.J., and Cole, S.T. (2014) Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Molecular Medicine. 6(3):372-383

van der Woude, A.D., Stoop, E.J., Stiess, M., Wang, S., Ummels, R., van Stempvoort, G., Piersma, S.R., Cascioferro, A., Jiménez, C.R., Houben, E.N., Luirink, J., Pieters, J., van der Sar, A.M., and Bitter, W. (2014) Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector. Cellular Microbiology. 16(2):280-95

Stoop, E.J., Mishra, A.K., Driessen, N.N., van Stempvoort, G., Bouchier, P., Verboom, T., van Leeuwen, L.M., Sparrius, M., Raadsen, S.A., van Zon, M., van der Wel, N.N., Besra, G.S., Geurtsen, J., Bitter, W., Appelmelk, B.J., and van der Sar, A.M. (2013) Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity. Cellular Microbiology. 15(12):2093-108

van der Woude, A.D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S.A., Boon, L., Geurtsen, J., van der Sar, A.M., Luirink, J., Houben, E.N., Besra, G.S., and Bitter, W. (2012) An Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum. The Journal of biological chemistry. 287(24):20417-20429

Weerdenburg, E.M., Abdallah, A.M., Mitra, S., de Punder, K., van der Wel, N.N., Bird, S., Appelmelk, B.J., Bitter, W., van der Sar, A.M. (2012) ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cellular Microbiology. 14(5):728-739

Stoop, E.J., Schipper, T., Rosendahl Huber, S.K., Nezhinsky, A.E., Verbeek, F.J., Gurcha, S.S., Besra, G.S., Vandenbroucke-Grauls, C.M., Bitter, W., and van der Sar, A.M. (2011) Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Disease models & mechanisms. 4(4):526-36

Llamas, M.A., van der Sar, A., Chu, B.C., Sparrius, M., Vogel, H.J., and Bitter, W. (2009) A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. PLoS pathogens. 5(9):e1000572

van der Sar, A.M., Spaink, H.P., Zakrzewska, A., Bitter, W., and Meijer, A.H. (2009) Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Molecular immunology. 46(11-12):2317-2332

Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., Debruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., and Richardson, M.K. (2009) Zebrafish development and regeneration: new tools for biomedical research. The International journal of developmental biology. 53(5-6):835-850

Meijer, A.H., van der Sar, A.M., Cunha, C., Lamers, G.E., Laplante, M.A., Kikuta, H., Bitter, W., Becker, T.S., and Spaink, H.P. (2008) Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Developmental and comparative immunology. 32(1):36-49

van der Sar, A.M., Abdallah, A.M., Sparrius, M., Reinders, E., Vandenbroucke-Grauls, C.M., and Bitter, W. (2004) Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. Infection and Immunity. 72(11):6306-6312

van der Sar, A.M., Appelmelk, B.J., Vandenbroucke-Grauls, C.M., and Bitter, W. (2004) A star with stripes: zebrafish as an infection model. Trends in microbiology. 12(10):451-457

NON-ZEBRAFISH PUBLICATIONS