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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-070426-1
van der Sar, Astrid M.
Email: a.vandersar@vumc.nl
URL:
Affiliation: Van der Sar Lab
Address: VU university medical center Dept. Medical Microbiology and Infection control Van der Boechorststraat 7 Amsterdam, 1081 BT Netherlands
Country: Netherlands
Phone: +31 20 4448296
Fax: +31 20 4448319
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Phan, T.H., van Leeuwen, L.M., Kuijl, C., Ummels, R., van Stempvoort, G., Rubio-Canalejas, A., Piersma, S.R., Jiménez, C.R., van der Sar, A.M., Houben, E.N.G., Bitter, W. (2018) EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF. PLoS pathogens. 14:e1007247
Bruinen, A.L., Fisher, G.L., Balez, R., van der Sar, A.M., Ooi, L., Heeren, R.M.A. (2018) Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 29(8):1571-1581
van Leeuwen, L.M., Boot, M., Kuijl, C., Picavet, D.I., van den Brink, G., van der Pol, S.M.A., de Vries, H.E., van der Wel, N.N., van der Kuip, M., van Furth, A.M., van der Sar, A.M., Bitter, W. (2018) Mycobacteria employ two different mechanisms to cross the blood-brain barrier. Cellular Microbiology. 20(9):e12858
van Leeuwen, L.M., Evans, R.J., Jim, K.K., Verboom, T., Fang, X., Bojarczuk, A., Malicki, J., Johnston, S.A., van der Sar, A.M. (2018) A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5.. Biology Open. 7(2)
Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2016) Correction: First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 11:e0169149
Jim, K.K., Engelen-Lee, J., van der Sar, A.M., Bitter, W., Brouwer, M.C., van der Ende, A., Veening, J.W., van de Beek, D., Vandenbroucke-Grauls, C.M. (2016) Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model. Journal of neuroinflammation. 13:188
Schneider, V.A., van Dijk, A., van der Sar, A.M., Kraaij, M.D., Veldhuizen, E.J., Haagsman, H.P. (2016) Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity. Developmental and comparative immunology. 60:108-14
Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2015) First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 10:e0126378
Torraca, V., Cui, C., Boland, R., Bebelman, J.P., van der Sar, A.M., Smit, M.J., Siderius, M., Spaink, H.P., Meijer, A.H. (2015) The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease models & mechanisms. 8(3):253-69
van Leeuwen, L.M., van der Sar, A.M., Bitter, W. (2014) Animal Models of Tuberculosis: Zebrafish. Cold Spring Harbor Perspectives in Medicine. 5(3):a018580
van Leeuwen, L.M., van der Kuip, M., Youssef, S.A., de Bruin, A., Bitter, W., van Furth, A.M., van der Sar, A.M. (2014) Modelling tuberculous meningitis in zebrafish using Mycobacterium marinum. Disease models & mechanisms. 7(9):1111-22
Makarov, V., Lechartier, B., Zhang, M., Neres, J., van der Sar, A.M., Raadsen, S.A., Hartkoorn, R.C., Ryabova, O.B., Vocat, A., Decosterd, L.A., Widmer, N., Buclin, T., Bitter, W., Andries, K., Pojer, F., Dyson, P.J., and Cole, S.T. (2014) Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Molecular Medicine. 6(3):372-383
van der Woude, A.D., Stoop, E.J., Stiess, M., Wang, S., Ummels, R., van Stempvoort, G., Piersma, S.R., Cascioferro, A., Jiménez, C.R., Houben, E.N., Luirink, J., Pieters, J., van der Sar, A.M., and Bitter, W. (2014) Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector. Cellular Microbiology. 16(2):280-95
Llamas, M.A., van der Sar, A.M. (2014) Assessing pseudomonas virulence with nonmammalian host: zebrafish. Methods in molecular biology (Clifton, N.J.). 1149:709-21
Stoop, E.J., Mishra, A.K., Driessen, N.N., van Stempvoort, G., Bouchier, P., Verboom, T., van Leeuwen, L.M., Sparrius, M., Raadsen, S.A., van Zon, M., van der Wel, N.N., Besra, G.S., Geurtsen, J., Bitter, W., Appelmelk, B.J., and van der Sar, A.M. (2013) Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity. Cellular Microbiology. 15(12):2093-108
Belo, A.I., van der Sar, A.M., Tefsen, B., and van Die, I. (2013) Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells. PLoS One. 8(6):e65957
van der Woude, A.D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S.A., Boon, L., Geurtsen, J., van der Sar, A.M., Luirink, J., Houben, E.N., Besra, G.S., and Bitter, W. (2012) An Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum. The Journal of biological chemistry. 287(24):20417-20429
Weerdenburg, E.M., Abdallah, A.M., Mitra, S., de Punder, K., van der Wel, N.N., Bird, S., Appelmelk, B.J., Bitter, W., van der Sar, A.M. (2012) ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cellular Microbiology. 14(5):728-739
Benard, E.L., van der Sar, A.M., Ellett, F., Lieschke, G.J., Spaink, H.P., and Meijer, A.H. (2012) Infection of zebrafish embryos with intracellular bacterial pathogens. Journal of visualized experiments : JoVE. (61)
Stoop, E.J., Schipper, T., Rosendahl Huber, S.K., Nezhinsky, A.E., Verbeek, F.J., Gurcha, S.S., Besra, G.S., Vandenbroucke-Grauls, C.M., Bitter, W., and van der Sar, A.M. (2011) Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component. Disease models & mechanisms. 4(4):526-36
Holt, A., Mitra, S., van der Sar, A.M., Alnabulsi, A., Secombes, C.J., and Bird, S. (2011) Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Molecular immunology. 48(8):981-991
Sieger, D., Stein, C., Neifer, D., van der Sar, A.M., and Leptin, M. (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Disease models & mechanisms. 2(11-12):571-581
van der Sar, A.M., Spaink, H.P., Zakrzewska, A., Bitter, W., and Meijer, A.H. (2009) Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Molecular immunology. 46(11-12):2317-2332
Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., Debruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., and Richardson, M.K. (2009) Zebrafish development and regeneration: new tools for biomedical research. The International journal of developmental biology. 53(5-6):835-850
Meijer, A.H., van der Sar, A.M., Cunha, C., Lamers, G.E., Laplante, M.A., Kikuta, H., Bitter, W., Becker, T.S., and Spaink, H.P. (2008) Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Developmental and comparative immunology. 32(1):36-49

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