ZFIN ID: ZDB-PERS-070119-1
Dong, Wu
Email: dongwu2002@hotmail.com
Affiliation: Wu Dong Lab
Address: Inner Mongolia Key Laboratory of Toxicants Monitoring and Toxicology Collage of animal science and technology Inner Mongolia University for the nationalities. 996 Xilamun Street, Tongliao, Inner Mongolia, China,028000

Toxicology and Development

Wang, H., Ma, C., Liu, C., Sun, L., Wang, Y., Xue, J., Zhao, B., Dong, W. (2024) The c-Fos/AP-1 inhibitor inhibits sulfur mustard-induced chondrogenesis impairment in zebrafish larvae. Chemosphere. 359:142299
Chen, C., Wang, X., Li, Y., Zhao, T., Wang, H., Gao, Y., Feng, Y., Wang, J., Shang, L., Wang, Y., Zhao, B., Dong, W. (2024) Hypobaric Hypoxia Causes Low Fecundity in Zebrafish Parents and Impairment of Skeletal Development in Zebrafish Embryos and Rat Offspring. Reproductive toxicology (Elmsford, N.Y.). 127:108603
Wang, H., Kang, G., Ma, C., Lian, H., Zhao, K., Zhao, B., Feng, Y., Dong, W. (2024) Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos. Bulletin of environmental contamination and toxicology. 112:3939
Chen, H., Mi, J., Li, S., Liu, Z., Yang, J., Chen, R., Wang, Y., Ban, Y., Zhou, Y., Dong, W., Sang, Z. (2023) Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. 38:21696822169682
Feng, C., Bai, H., Chang, X., Wu, Z., Dong, W., Ma, Q., Yang, J. (2023) Aflatoxin B1-induced early developmental hepatotoxicity in larvae zebrafish. Chemosphere. 340:139940
Chen, R., Li, X., Chen, H., Wang, K., Xue, T., Mi, J., Ban, Y., Zhu, G., Zhou, Y., Dong, W., Tang, L., Sang, Z. (2023) Development of the "hidden" multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 251:115253115253
Ni, X., Yin, X., Qi, C., Liu, C., Chen, H., Zhou, Y., Ao, W., Bao, S., Xue, J., Yang, J., Dong, W. (2022) Cardiotoxicity of (-)-borneol, (+)-borneol, and isoborneol in Zebrafish embryos is associated with Na+ /K+ -ATPase and Ca2+ -ATPase inhibition. Journal of applied toxicology : JAT. 43(3):373-386
Zhou, Y., Li, T., Zhou, S., Xu, H., Yin, X., Chen, H., Ni, X., Bai, M., Ao, W., Yang, J., Ahmed, R.G., Zhang, X., Bao, S., Yu, J., Kwok, K.W.H., Dong, W. (2022) Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway. Metabolic Brain Disease. 37(7):2559-2568
Sa, R., Feng, C., Bai, H., Yin, X., Song, L., Hu, X., Xu, R., Li, X., Dong, W., Yang, J. (2022) Inhibitory Effects of Mongolian Medicine Yihe-Tang on Continuous Darkness Induced Liver Steatosis in Zebrafish. Evidence-based complementary and alternative medicine : eCAM. 2022:5794655
Song, L., Li, M., Feng, C., Sa, R., Hu, X., Wang, J., Yin, X., Qi, C., Dong, W., Yang, J. (2022) Protective effect of curcumin on zebrafish liver under ethanol-induced oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 258:109360
Chen, C., Ni, X., Yin, X., Chen, H., Zhou, Y., Sun, H., Qi, C., Bu, N., Wang, S., Yu, J., Yang, J., Ao, W., Zhao, B., Dong, W. (2022) Developmental disorders caused by cefixime in the otic vesicles of zebrafish embryos or larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 255:109295
Yin, X., Liu, W., Chen, H., Qi, C., Chen, H., Niu, H., Yang, J., Kwok, K.W.H., Dong, W. (2021) Effects of ferulic acid on muscle development and intestinal microbiota of zebrafish. Journal of animal physiology and animal nutrition. 106(2):429-440
Feng, C., Sarigaiqiqige, ., Liu, W., Chen, H., Dong, W., Yang, J. (2021) Effect of dark environment on intestinal flora and expression of genes related to liver metabolism in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 249:109100
Dong, W., Han, X., Bao, C., Tai, S., Bai, Y., Xu, L., Yang, J., Leung, T., Ao, W., Dong, W. (2021) Inhibitory Effects of Euphorbia ebracteolata Hayata Extract ECB on Melanoma-Induced Hyperplasia of Blood Vessels in Zebrafish Embryos. Evidence-based complementary and alternative medicine : eCAM. 2021:5543259
Chen, H., Wang, F., Ni, X., Rigui, Y., Bai, Y., Xu, L., Yang, J., Zhang, X., Deng, J., Li, J., Yin, X., Ao, W., Kwok, K.W.H., Dong, W. (2020) Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo. Journal of applied toxicology : JAT. 41(3):483-492
Keerthisinghe, T.P., Wang, F., Wang, M., Yang, Q., Li, J., Yang, J., Xi, L., Dong, W., Fang, M. (2020) Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome. Environment International. 139:105705
Dong, W., Wang, F., Fang, M., Wu, J., Wang, S., Li, M., Yang, J., Chernick, M., Hinton, D.E., Pei, D.S., Chen, H., Zheng, N., Mu, J., Xie, L., Dong, W. (2019) Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China. Ecotoxicology and environmental safety. 173:339-346
Chen, X., Fang, M., Chernick, M., Wang, F., JingfengYang, ., Yu, Y., Zheng, N., Teraoka, H., Nanba, S., Hiraga, T., Hinton, D.E., Dong, W. (2018) The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). General and comparative endocrinology. 271:73-81
Wang, F., Fang, M., Hinton, D.E., Chernick, M., Jia, S., Zhang, Y., Xie, L., Dong, W., Dong, W. (2018) Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere. 198:342-350
Massarsky, A., Bone, A.J., Dong, W., Hinton, D.E., Prasad, G.L., Di Giulio, R.T. (2016) AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. Toxicology and applied pharmacology. 309:63-76
Fang, M., Guo, J., Chen, D., Li, A., Hinton, D.E., Dong, W. (2016) Halogenated carbazoles induce cardiotoxicity in developing zebrafish embryos (Danio rerio). Environmental toxicology and chemistry. 35(10):2523-2529
Macaulay, L.J., Chen, A., Rock, K.D., Dishaw, L.V., Dong, W., Hinton, D.E., Stapleton, H.M. (2015) Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquatic toxicology (Amsterdam, Netherlands). 168:38-47
Dong, W., Macaulay, L.J., Kwok, K.W., Hinton, D.E., and Stapleton, H.M. (2013) Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. Aquatic toxicology (Amsterdam, Netherlands). 132-133:190-199
Teraoka, H., Kubota, A., Dong, W., Kawai, Y., Yamazaki, K., Mori, C., Harada, Y., Peterson, R.E., and Hiraga, T. (2009) Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo. Toxicology and applied pharmacology. 234(1):33-40
Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., and Hiraga, T. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquatic toxicology (Amsterdam, Netherlands). 78(2):103-113
Dong, W., Muramoto, W., Nagai, Y., Takehana, K., Stegeman, J.J., Teraoka, H., and Hiraga, T. (2006) Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish. The Journal of veterinary medical science. 68(6):573-579
Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R.L., Svoboda, K., Handley-Goldstone, H.M., Stegeman, J.J., and Hiraga, T. (2006) Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicology and applied pharmacology. 212(1):24-34
Teraoka, H., Russell, C., Regan, J., Chandrasekhar, A., Concha, M.L., Yokoyama, R., Higashi, K., Take-Uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson, S.W. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. 60(3):275-288
Dong, W., Teraoka, H., Tsujimoto, Y., Stegeman, J.J., and Hiraga, T. (2004) Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 77(1):109-116
Prasch, A.L., Teraoka, H., Carney, S.A., Dong, W., Hiraga, T., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2003) Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):138-150
Teraoka, H., Dong, W., and Hiraga, T. (2003) Zebrafish as a novel experimental model for developmental toxicology. Congenital anomalies. 43(2):123-132
Teraoka, H., Dong, W., Tsujimoto, Y., Iwasa, H., Endoh, D., Ueno, N., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2003) Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochemical and Biophysical Research Communications. 304(2):223-228
Dong, W., Teraoka, H., Yamazaki, K., Tsukiyama, S., Imani, S., Imagawa, T., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. 69(1):191-201
Yamazaki, K., Teraoka, H., Dong, W., Stegeman, J.J., and Hiraga, T. (2002) cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. The Journal of veterinary medical science. 64(9):829-833
Teraoka, H., Dong, W., Ogawa, S., Tsukiyama, S., Okuhara, Y., Niiyama, M., Ueno, N., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: altered regional blood flow and impaired lower jaw development. Toxicological sciences : an official journal of the Society of Toxicology. 65(2):192-199
Dong, W., Teraoka, H., Tsukiyama, S., Yamazaki, K., Imani, S., Imagawa, T.,Kondo, S. and Hiraga, T. (2002) 2,3,7,8-tetrachlorodibenzo-p-dioxin induces apoptosis in central nervous system- Correlation between local circulation failure and apoptosis in the dorsal midbrain of zebrafish embryos. Rakuno Gakuen Univ.. 26:301-314
Dong, W., Teraoka, H., Kondo, S., and Hiraga, T. (2001) 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor. Neuroscience letters. 303(3):169-172

Dong, W. and Willett K. L. Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus). 2008. Gen Comp Endocrinol. 155(2):307-17.

Dong, W., Wang, L., Hickman, C. and Willett, K.L. Benzo(a)pyrene decrease brain and ovary aromatase mRNA expression. 2008. Aquat. Toxicol. 88(4), 289-300.