ZFIN ID: ZDB-PERS-060802-4
Kizil, Caghan
Email: caghan.kizil@dzne.de
URL: http://kizillab.org
Affiliation: Kizil Lab, Mechanisms of induced Plasticity of the Vertebrate Brain
Address: German Center for Neurodegenerative Diseases (DZNE) Dresden Fetscherstr. 105, 01307 Dresden, Germany
Country: Germany
Phone: +49 351 458 82311
Fax: +49 351 458 82309
Orcid ID: 0000-0002-8164-9762


BIOGRAPHY AND RESEARCH INTERESTS
Our goal is to learn from zebrafish how to enable the adult brain to better cope with neurodegenerative disease and regenerate. The main motivation of our research group is to understand the molecular programs for zebrafish brain to induce regenerative stem cell plasticity.

The brains of aging humans are prone to neurodegenerative disorders and we are unable to counteract neuronal loss by regenerating lost cells. Patients with neurodegenerative conditions progressively loose neurons yet cannot form new neurons that would replace the lost ones – namely, we humans lack the proper “plasticity response”. We are using zebrafish as a model organism that can regenerate its brain effectively. We try to learn from fish the molecular programs underlying such an aptitude, and developing innovative tools for comparative studies in mammalian brains.


PUBLICATIONS
Kizil, C., Bhattarai, P. (2018) Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective. Frontiers in cell and developmental biology. 6:159
Kizil, C. (2018) Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain. Current pathobiology reports. 6:71-77
Bhattarai, P., Thomas, A.K., Cosacak, M.I., Papadimitriou, C., Mashkaryan, V., Zhang, Y., Kizil, C. (2017) Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain. Journal of visualized experiments : JoVE. (128)
Cosacak, M.I., Bhattarai, P., Bocova, L., Dzewas, T., Mashkaryan, V., Papadimitriou, C., Brandt, K., Hollak, H., Antos, C.L., Kizil, C. (2017) Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.. Scientific Reports. 7:12959
Bhattarai, P., Thomas, A.K., Zhang, Y., Kizil, C. (2017) The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain. Neurogenesis (Austin, Tex.). 4:e1322666
Bhattarai, P., Thomas, A.K., Cosacak, M.I., Papadimitriou, C., Mashkaryan, V., Froc, C., Reinhardt, S., Kurth, T., Dahl, A., Zhang, Y., Kizil, C. (2016) IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. Cell Reports. 17:941-948
Tincer, G., Mashkaryan, V., Bhattarai, P., Kizil, C. (2016) Neural stem/progenitor cells in Alzheimer's disease. The Yale journal of biology and medicine. 89:23-35
Kizil, C., Iltzsche, A., Thomas, A.K., Bhattarai, P., Zhang, Y., Brand, M. (2015) Efficient cargo delivery into adult brain tissue using short cell-penetrating peptides. PLoS One. 10:e0124073
Kizil, C., Kyritsis, N., Brand, M. (2015) Effects of inflammation on stem cells: together they strive?. EMBO reports. 16(4):416-426
Cosacak, M.I., Papadimitriou, C., Kizil, C. (2015) Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International. 2015:769763
Kizil, C., Küchler, B., Yan, J.J., Özhan, G., Moro, E., Argenton, F., Brand, M., Weidinger, G., Antos, C.L. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development (Cambridge, England). 141:3529-39
Kizil, C., Iltzsche, A., Kaslin, J., and Brand, M. (2013) Micromanipulation of gene expression in the adult zebrafish brain using cerebroventricular microinjection of morpholino oligonucleotides. Journal of visualized experiments : JoVE. (75):e50415
Kizil, C., Kyritsis, N., Dudczig, S., Kroehne, V., Freudenreich, D., Kaslin, J., and Brand, M. (2012) Regenerative Neurogenesis from Neural Progenitor Cells Requires Injury-Induced Expression of Gata3. Developmental Cell. 23(6):1230-1237
Kyritsis, N., Kizil, C., Zocher, S., Kroehne, V., Kaslin, J., Freudenreich, D., Iltzsche, A., and Brand, M. (2012) Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain. Science (New York, N.Y.). 338(6112):1353-1356
Kizil, C., Dudczig, S., Kyritsis, N., Machate, A., Blaesche, J., Kroehne, V., and Brand, M. (2012) The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Development. 7(1):27
Kizil, C., Kaslin, J., Kroehne, V., and Brand, M. (2012) Adult neurogenesis and brain regeneration in zebrafish. Developmental Neurobiology. 72(3):429-461
Kizil, C., and Brand, M. (2011) Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells. PLoS One. 6(11):e27395
Kizil, C., Otto, G.W., Geisler, R., Nüsslein-Volhard, C., and Antos, C.L. (2009) Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 325(2):329-340
Kizil, C. (2009) Characterization of fam53b, simplet (smp) gene in caudal fin regeneration and embryonic development of zebrafish (Danio rerio). Ph.D. Thesis. :126p

NON-ZEBRAFISH PUBLICATIONS
Kizil C. (2011) Turkish science seeks freedom. Science. 334(6055):452-3.

Kizil C. (2011) Academic autonomy: more freedom for Turkish science. Nature. 477(7366):538.

Altindis E, Alpar MA, Aksay E, Beckwith J, Bokel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, Lipkin SM, Poulopoulou C, Raz E, Rubin MA, Salturk M, Schrock RR, Trautmann A, Unutmaz D, Weinstein H, Kizil C. (2013) Turkey must end violent response to protests. Science. 341(6143):236.

Kizil C. Government: Concern grows for Turkey's academics. Nature. 2016 Jan 28;529(7587):466. doi: 10.1038/529466a. PubMed PMID: 26819036.

Kizil C. (2017) An existential threat. New Scientist. 234(3121):24-25. doi: 10.1016/S0262-4079(17)30727-3.

Kizil C. (2016) Degrees of freedom. New Scientist. 231(3084):20-21. doi: 10.1016/S0262-4079(16)31366-5.