ZFIN Person: White, Richard M.

ZFIN ID: ZDB-PERS-060712-8

White, Richard M.

Email:	whiter@mskcc.org
URL:	http://www.mskcc.org/research-areas/labs/richard-white
Affiliation:	White Lab
Address:	Memorial Sloan Kettering Cancer Center Weill Cornell Medical College 1275 York Avenue, Box 424 New York, N.Y. 10075
Country:	United States
Phone:	646-888-3415
Fax:	646-422-0231
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Feiner, R., Johns, E., Antman-Passig, M., Irie, T., Berisha, N., Oved, H., Khan, D., Witek, L., White, R.M., Heller, D.A. (2022) Drug-Eluting Rubber Bands for Tissue Ligation. ACS applied materials & interfaces. 14(24):27675-27685

Hason, M., Jovicic, J., Vonkova, I., Bojic, M., Simon-Vermot, T., White, R.M., Bartunek, P. (2022) Bioluminescent Zebrafish Transplantation Model for Drug Discovery. Frontiers in pharmacology. 13:893655

Weiss, J.M., Hunter, M.V., Cruz, N.M., Baggiolini, A., Tagore, M., Ma, Y., Misale, S., Marasco, M., Simon-Vermot, T., Campbell, N.R., Newell, F., Wilmott, J.S., Johansson, P.A., Thompson, J.F., Long, G.V., Pearson, J.V., Mann, G.J., Scolyer, R.A., Waddell, N., Montal, E.D., Huang, T.H., Jonsson, P., Donoghue, M.T.A., Harris, C.C., Taylor, B.S., Xu, T., Chaligné, R., Shliaha, P.V., Hendrickson, R., Jungbluth, A.A., Lezcano, C., Koche, R., Studer, L., Ariyan, C.E., Solit, D.B., Wolchok, J.D., Merghoub, T., Rosen, N., Hayward, N.K., White, R.M. (2022) Anatomic position determines oncogenic specificity in melanoma. Nature. 604(7905):354-361

Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278

Campbell, N.R., Rao, A., Hunter, M.V., Sznurkowska, M.K., Briker, L., Zhang, M., Baron, M., Heilmann, S., Deforet, M., Kenny, C., Ferretti, L.P., Huang, T.H., Perlee, S., Garg, M., Nsengimana, J., Saini, M., Montal, E., Tagore, M., Newton-Bishop, J., Middleton, M.R., Corrie, P., Adams, D.J., Rabbie, R., Aceto, N., Levesque, M.P., Cornell, R.A., Yanai, I., Xavier, J.B., White, R.M. (2021) Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Developmental Cell. 56(20):2808-2825.e10

Baggiolini, A., Callahan, S.J., Montal, E., Weiss, J.M., Trieu, T., Tagore, M.M., Tischfield, S.E., Walsh, R.M., Suresh, S., Fan, Y., Campbell, N.R., Perlee, S.C., Saurat, N., Hunter, M.V., Simon-Vermot, T., Huang, T.H., Ma, Y., Hollmann, T., Tickoo, S.K., Taylor, B.S., Khurana, E., Koche, R.P., Studer, L., White, R.M. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science (New York, N.Y.). 373:eabc1048

Lumaquin, D., Johns, E., Montal, E., Weiss, J.M., Ola, D., Abuhashem, A., White, R.M. (2021) An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. eLIFE. 10:

Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J., Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. (2021) Melanoma models for the next generation of therapies. Cancer Cell. 39(5):610-631

Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:

Baron, M., Tagore, M., Hunter, M.V., Kim, I.S., Moncada, R., Yan, Y., Campbell, N.R., White, R.M., Yanai, I. (2020) The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. Cell systems. 11(5):536-546.e7

D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):

Cagan, R.L., Zon, L.I., White, R.M. (2019) Modeling Cancer with Flies and Fish. Developmental Cell. 49:317-324

Liu, P.H., Shah, R.B., Li, Y., Arora, A., Ung, P.M., Raman, R., Gorbatenko, A., Kozono, S., Zhou, X.Z., Brechin, V., Barbaro, J.M., Thompson, R., White, R.M., Aguirre-Ghiso, J.A., Heymach, J.V., Lu, K.P., Silva, J.M., Panageas, K.S., Schlessinger, A., Maki, R.G., Skinner, H.D., de Stanchina, E., Sidi, S. (2019) An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nature cell biology. 21(2):203-213

Callahan, S.J., Tepan, S., Zhang, Y.M., Lindsay, H., Burger, A., Campbell, N.R., Kim, I.S., Hollmann, T.J., Studer, L., Mosimann, C., White, R.M. (2018) Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Disease models & mechanisms. 11(9):

Zhang, M., Di Martino, J.S., Bowman, R.L., Campbell, N.R., Baksh, S.C., Simon-Vermot, T., Kim, I.S., Haldeman, P., Mondal, C., Yong-Gonzalez, V., Abu-Akeel, M., Merghoub, T., Jones, D.R., Zhu, X.G., Arora, A., Ariyan, C.E., Birsoy, K., Wolchok, J.D., Panageas, K.S., Hollmann, T.J., Bravo-Cordero, J.J., White, R.M. (2018) Adipocyte-derived lipids mediate melanoma progression via FATP proteins. Cancer discovery. 8(8):1006-1025

Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7

D'Agati, G., Beltre, R., Sessa, A., Burger, A., Zhou, Y., Mosimann, C., White, R.M. (2017) A defect in the mitochondrial protein mpv17 underlies the transparent casper zebrafish. Developmental Biology. 430(1):11-17

Perry, E.B., Makohon-Moore, A., Zheng, C., Kaufman, C.K., Cai, J., Iacobuzio-Donahue, C.A., White, R.M. (2017) Tumor diversity and evolution revealed through RADseq. Oncotarget. 8(26):41792-41805

Kim, I.S., Heilmann, S., Kansler, E.R., Zhang, Y., Zimmer, M., Ratnakumar, K., Bowman, R.L., Simon-Vermot, T., Fennell, M., Garippa, R., Lu, L., Lee, W., Hollmann, T., Xavier, J.B., White, R.M. (2017) Microenvironment-derived factors driving metastatic plasticity in melanoma. Nature communications. 8:14343

Kansler, E.R., Verma, A., Langdon, E.M., Simon-Vermot, T., Yin, A., Lee, W., Attiyeh, M., Elemento, O., White, R.M. (2017) Melanoma genome evolution across species. BMC Genomics. 18:136

Tan, J.L., Fogley, R.D., Flynn, R.A., Ablain, J., Yang, S., Saint-André, V., Fan, Z.P., Do, B.T., Laga, A.C., Fujinaga, K., Santoriello, C., Greer, C.B., Kim, Y.J., Clohessy, J.G., Bothmer, A., Pandell, N., Avagyan, S., Brogie, J.E., van Rooijen, E., Hagedorn, E.J., Shyh-Chang, N., White, R.M., Price, D.H., Pandolfi, P.P., Peterlin, B.M., Zhou, Y., Kim, T.H., Asara, J.M., Chang, H.Y., Young, R.A., Zon, L.I. (2016) Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell. 62:34-46

Kaufman, C.K., Mosimann, C., Fan, Z.P., Yang, S., Thomas, A.J., Ablain, J., Tan, J.L., Fogley, R.D., van Rooijen, E., Hagedorn, E.J., Ciarlo, C., White, R.M., Matos, D.A , Puller, A.C., Santoriello, C., Liao, E.C., Young, R.A., and Zon, L.I. (2016) A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science (New York, N.Y.). 351(6272):aad2197

Wojciechowska, S., van Rooijen, E., Ceol, C., Patton, E.E., White, R.M. (2016) Generation and analysis of zebrafish melanoma models. Methods in cell biology. 134:531-49

White, R.M. (2016) Genomic Approaches to Zebrafish Cancer. Advances in experimental medicine and biology. 916:125-45

Heilmann, S., Ratnakumar, K., Langdon, E., Kansler, E., Kim, I., Campbell, N.R., Perry, E., McMahon, A., Kaufman, C., van Rooijen, E., Lee, W., Iacobuzio-Donahue, C., Hynes, R., Zon, L., Xavier, J., White, R.M. (2015) A quantitative system for studying metastasis using transparent zebrafish. Cancer research. 75(20):4272-82

White, R.M. (2015) Cross-species oncogenomics using zebrafish models of cancer. Current opinion in genetics & development. 30:73-9

Yen, J., White, R.M., Stemple, D.L. (2014) Zebrafish models of cancer: progress and future challenges. Current opinion in genetics & development. 24C:38-45

Paik, E.J., Mahony, S., White, R.M., Price, E.N., Dibiase, A., Dorjsuren, B., Mosimann, C., Davidson, A.J., Gifford, D., and Zon, L.I. (2013) A cdx4-sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 1(5):425-436

White, R., Rose, K., and Zon, L. (2013) Zebrafish cancer: the state of the art and the path forward. Nature reviews. Cancer. 3(9):624-636

Tamplin, O.J., White, R.M., Jing, L., Kaufman, C.K., Lacadie, S.A., Li, P., Taylor, A.M., and Zon, L.I. (2012) Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdisciplinary Reviews: Developmental Biology. 1(3):459-468

Taylor, A.M., Humphries, J.M., White, R.M., Murphey, R.D., Burns, C.E., and Zon, L.I. (2012) Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Experimental hematology. 40(3):228-237

Zhang, L., Alt, C., Li, P., White, R.M., Zon, L.I., Wei, X., and Lin, C.P. (2012) An optical platform for cell tracking in adult zebrafish. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 81(2):176-182

White, R.M., Cech, J., Ratanasirintrawoot, S., Lin, C.Y., Rahl, P.B., Burke, C.J., Langdon, E., Tomlinson, M.L., Mosher, J., Kaufman, C., Chen, F., Long, H.K., Kramer, M., Datta, S., Neuberg, D., Granter, S., Young, R.A., Morrison, .S, Wheeler, G.N., and Zon, L.I. (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471(7339):518-522

Li, P., White, R.M., and Zon, L.I. (2011) Transplantation in zebrafish. Methods in cell biology. 105:403-417

Feng, H., Stachura, D.L., White, R.M., Gutierrez, A., Zhang, L., Sanda, T., Jette, C.A., Testa, J.R., Neuberg, D.S., Langenau, D.M., Kutok, J.L., Zon, L.I., Traver, D., Fleming, M.D., Kanki, J.P., and Look, A.T. (2010) T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 18(4):353-366

Pugach, E.K., Li, P., White, R., and Zon, L. (2009) Retro-orbital injection in adult zebrafish. Journal of visualized experiments : JoVE. (34)

Dovey, M., White, R.M., and Zon, L.I. (2009) Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish. Zebrafish. 6(4):397-404

Kaufman, C.K., White, R.M., and Zon, L. (2009) Chemical genetic screening in the zebrafish embryo. Nature Protocols. 4(10):1422-1432

Ceol, C.J., Houvras, Y., White, R.M., and Zon, L.I. (2008) Melanoma biology and the promise of zebrafish. Zebrafish. 5(4):247-255

Sessa, A.K., White, R., Houvras, Y., Burke, C., Pugach, E., Baker, B., Gilbert, R., Look, A.T., and Zon, L.I. (2008) The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. Zebrafish. 5(4):335-339

White, R.M., and Zon, L.I. (2008) Melanocytes in Development, Regeneration, and Cancer. Cell Stem Cell. 3(3):242-252

White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C. Bourque, C., Dovey, M., Goessling, W., Burns, C.E., and Zon, L.I. (2008) Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis. Cell Stem Cell. 2(2):183-189

NON-ZEBRAFISH PUBLICATIONS