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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-060601-3
Hsiao, Chung-Der
Email: cdhsiao@yahoo.com.tw
URL: http://cdhsiao.weebly.com
Affiliation: Epidermal Stem Cell Lab
Address: Epidermal Stem Cell Lab Department of Bioscience Technology Chung Yuan Christian Univ. 200, Chung Pei Rd. Chung-Li, 32023 Taiwan
Country: Taiwan
Phone: 886-3-2653545
Fax: 886-3-2653599
Orcid ID: 0000-0002-6398-8672


BIOGRAPHY AND RESEARCH INTERESTS
Chung-Der Hsiao is Professor of Chung Yuan Christian University for Department of Bioscience Technology. He completed the undergraduate and graduate education in National Taiwan University. For postdoctoral training, he joined Dr. Pung-Pung Hwang's group at ICOB, Academia Sinica, and worked on fish physiology and bioinformatics. By 2007, Chung-Der was recruited by Chung Yuan Christian University and established his own laboratory, where he used the cutting-edge methods to generate many zebrafish disease models like apoptosis, obesity, skin cancer and aging. From 2012, Chung-Der was invited by GeneTex International Corp, Zgenebio Biotech and Taikong Corp as research consultant to initiate several cooperation projects on developing zebrafish antibodies, TALEN/CRISPR genome editing tools, transgenic fish as well as Next Generation Sequencing technologies. From 2019, Chung-Der was promoted as professor of Chung Yuan Christian University. Chung-Der is author of over 100 high impact journal articles. He is frequently invited to talk at international and local conferences across a diverse range of fields, and has also spoken to school, student and public audiences. His research has strong application potentials and several patents have been issued regarding to use zebrafish as a human disease models like aging, obesity and cancer.


PUBLICATIONS
Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)
Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Correction for Zhang et al., "Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish". Antimicrobial Agents and Chemotherapy. 63(7)
Sampurna, B.P., Santoso, F., Lee, J.H., Yu, W.H., Wu, C.C., Audira, G., Juniardi, S., Chen, J.R., Lin, Y.T., Hsiao, C.D. (2019) Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish. Cells. 8(6)
Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., Han, L., Hsiao, C.D. (2019) Establishing simple image-based methods and cost-effective instrument for toxicity assessment on circadian rhythm dysregulation in fish. Biology Open. 8(6):
Liang, S.T., Audira, G., Juniardi, S., Chen, J.R., Lai, Y.H., Du, Z.C., Lin, D.S., Hsiao, C.D. (2019) Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities. Cells. 8(5):
Jia, Z.L., Cen, J., Wang, J.B., Zhang, F., Xia, Q., Wang, X., Chen, X.Q., Wang, R.C., Hsiao, C.D., Liu, K.C., Zhang, Y. (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 227:541-550
Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Hepatotoxicity induced by Isoniazid/Lipopolysaccharide through ERS-, autophagy- and apoptosis pathway in zebrafish. Antimicrobial Agents and Chemotherapy. 63(5):
Audira, G., Sarasamma, S., Chen, J.R., Juniardi, S., Sampurna, B.P., Liang, S.T., Lai, Y.H., Lin, G.M., Hsieh, M.C., Hsiao, C.D. (2018) Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation. International Journal of Molecular Sciences. 19(12):
Jin, M., Xiao, Z., Zhang, S., Men, X., Li, X., Zhang, B., Zhou, T., Hsiao, C.D., Liu, K. (2018) Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere. 219:557-566
Sarasamma, S., Lai, Y.H., Liang, S.T., Liu, K., Hsiao, C.D. (2018) The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities. International Journal of Molecular Sciences. 19(12)
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Lai, Y.H., Hao, E., Chen, J.R., Hsiao, C.D. (2018) Evaluation of the Effects of Carbon 60 Nanoparticle Exposure to Adult Zebrafish: A Behavioral and Biochemical Approach to Elucidate the Mechanism of Toxicity. International Journal of Molecular Sciences. 19(12):
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Liang, S.T., Hao, E., Lai, Y.H., Hsiao, C.D. (2018) Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish. International Journal of Molecular Sciences. 19(10)
Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Liang, S.T., Hao, E., Lai, Y.H., and Hsiao, C.D. (2018) Zinc chloride exposure inhibits brain acetylcholine level and produces neurotoxic signatures and diminish memory and motor activities in adult zebrafish.. International Journal of Molecular Sciences. 19(10)
Xiong, X.Y., Liu, Y., Shan, L.T., Xu, Y.Q., Liang, J., Lai, Y.H., Hsiao, C.D. (2018) Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration. Biochemical and Biophysical Research Communications. 505(2):516-522
Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856
Sampurna, B.P., Audira, G., Juniardi, S., Lai, Y.H., and Hsiao, C.D. (2018) A Simple ImageJ-Based Method to Measure Cardiac Rhythm in Zebrafish Embryos. Inventions. 3(2)
Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., and Hsiao, C.D. (2018) A Simple Setup to Perform 3D Locomotion Tracking in Zebrafish by Using a Single Camera. Inventions. 3(1)
Schepis, A., Barker, A., Srinivasan, Y., Balouch, E., Zheng, Y., Lam, I., Clay, H., Hsiao, C.D., Coughlin, S.R. (2018) Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of cell biology. 217(3):1097-1112
Chen, J.R., Lai, Y.H., Tsai, J.J., Hsiao, C.D. (2017) Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization. Molecules. 22(12)
Sarasamma, S., Varikkodan, M.M., Liang, S.T., Lin, Y.C., Wang, W.P., Hsiao, C.D. (2017) Zebrafish: A Premier Vertebrate Model for Biomedical Research in Indian Scenario. Zebrafish. 14(6):589-605
Zhang, Y., Han, L., He, Q., Chen, W., Sun, C., Wang, X., Chen, X., Wang, R., Hsiao, C.D., Liu, K. (2017) A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. Journal of Pharmacological and Toxicological Methods. 84:102-110
Zhang, Y., Liu, K., Hassan, H.M., Guo, H., Ding, P., Han, L., He, Q., Chen, W., Hsiao, C.D., Zhang, L., Jiang, Z. (2016) L-FABP-deficiency provoked oxidative stress, inflammation and apoptosis-mediated hepatotoxicity induced by pyrazinamide on zebrafish larvae. Antimicrobial Agents and Chemotherapy. 60(12):7347-7356
Sun, G., Liu, K., Wang, X., Liu, X., He, Q., Hsiao, C.D. (2015) Identification and Expression Analysis of Zebrafish (Danio rerio) E-Selectin during Embryonic Development. Molecules. 20:18539-18550
Chang, T.Y., Huang, T.S., Wang, H.W., Chang, S.J., Lo, H.H., Chiu, Y.L., Wang, Y.L., Hsiao, C.D., Tsai, C.H., Chan, C.H., You, R.I., Wu, C.H., Tsai, T.N., Cheng, S.M., Cheng, C.C. (2014) miRNome traits analysis on endothelial lineage cells discloses biomarker potential circulating microRNAs which affect progenitor activities. BMC Genomics. 15:802
Huang, S.Y., Feng, C.W., Hung, H.C., Chakraborty, C., Chen, C.H., Chen, W.F., Jean, Y.H., Wang, H.M., Sung, C.S., Sun, Y.M., Wu, C.Y., Liu, W., Hsiao, C.D., Wen, Z.H. (2014) A Novel Zebrafish Model to Provide Mechanistic Insights into the Inflammatory Events in Carrageenan-Induced Abdominal Edema. PLoS One. 9:e104414
Chen, C.H., Lin, D.S., Cheng, C.W., Lin, C.J., Lo, Y.K., Yen, C.C., Lee, A.Y., Hsiao, C.D. (2014) Cdc6 cooperates with c-Myc to promote genome instability and EMT in zebrafish. Oncotarget. 5(15):6300-11
Feng, C.W., Wen, Z.H., Huang, S.Y., Hung, H.C., Chen, C.H., Yang, S.N., Chen, N.F., Wang, H.M., Hsiao, C.D., Chen, W.F. (2014) Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae. Zebrafish. 11(3):227-39
Chen, S.Y., Shih, H.Y., Lin, S.J., Hsiao, C.D., Li, Z.C., and Cheng, Y.C. (2013) Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science. 126(Pt 24):5626-34
Shih, D.F., Hsiao, C.D., Min, M.Y., Lai, W.S., Yang, C.W., Lee, W.T., and Lee, S.J. (2013) Aromatic L-Amino Acid Decarboxylase (AADC) Is Crucial for Brain Development and Motor Functions. PLoS One. 8(8):e71741
Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788
Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
Yeh, C.M., Liu, Y.C., Chang, C.J., Lai, S.L., Hsiao, C.D., and Lee, S.J. (2011) Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish. PLoS One. 6(4):e18702
Huang, S.H., Hsiao, C.D., Lin, D.S., Chow, C.Y., Chang, C.J., and Liau, I. (2011) Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. PLoS One. 6(9):e24764
Liu, D.W., Hsu, C.H., Tsai, S.M., Hsiao, C.D., and Wang, W.P. (2011) A variant of fibroblast growth factor receptor 2 (fgfr2) regulates left-right asymmetry in zebrafish. PLoS One. 6(7):e21793
Chen, C.F., Chu, C.Y., Chen, T.H., Lee, S.J., Shen, C.N., and Hsiao, C.D. (2011) Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo. PLoS One. 6(5):e20654
Chang, W.J., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2009) The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(4):R1192-R1201
Tseng, D.Y., Chou, M.Y., Tseng, Y.C., Hsiao, C.D., Huang, C.J., Kaneko, T., and Hwang, P.P. (2009) Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. American journal of physiology. Regulatory, integrative and comparative physiology. 296(3):R549-R557
Chou, M.Y., Hsiao, C.D., Chen, S.C., Chen, I.W., Liu, S.T., and Hwang, P.P. (2008) Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation and function of ionocytes as compensatory responses. The Journal of experimental biology. 211(Pt 19):3077-3084
Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260
Hsiao, C.D., You, M.S., Guh, Y.J., Ma, M., Jiang, Y.J., and Hwang, P.P. (2007) A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes. PLoS One. 2(1):e302
Hsiao, C.D., Ekker, M., and Tsai, H.J. (2003) Skin-specific expression of ictacalcin, a homolog of the S100 genes, during zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 228(4):745-750
Hsiao, C.-D. and Tsai, H.-J. (2003) Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo. Developmental Biology. 262:313-323
Hsiao, C.-D., Tsai, W.-Y., Horng, L.-S., and Tsai, H.-J. (2003) Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 227:266-279
Hsiao, C.D., Tsai, W.Y., and Tsai, H.J. (2002) Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin. Mechanisms of Development. (Suppl.) 119:S161-S166
Hsiao, C.D., Hsieh, F.J., and Tsai, H.J. (2001) Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 220(4):323-336

NON-ZEBRAFISH PUBLICATIONS
Hao E, Pang G, Du Z, Lai YH, Chen JR, Xie J, Zhou K, Hou X*, Hsiao CD*, Deng J*. 2019. Peach Kernel Oil Downregulates Expression of Tissue Factor and Reduces Atherosclerosis in ApoE knockout Mice. Int. J. Mol. Sci. 20, 405.​

​Lin GM, Lai YH, Audira G, Hsiao CD*. 2017. A simple method to decode the complete 18-5.8-28S rRNA repeated units of green algae by genome skimming. Int. J. Mol. Sci. 18:2341.

Lee SC, Hsiao CD, Wang YS, Lou SW*. 2017. Transcriptome response of previtellogenic ovary in Anguilla japonica after artificial hormone injection. Mar Genomics 35:31-34. ​ ​

Zhang H, Audira G, Li Y, Xian W*, Varikkodan MM, Hsiao CD*. 2017. Comparative study the expression of calcium cycling genes in Bombay duck (Harpadon nehereus) and beltfish (Trichiurus lepturus) with different swimming activities. Genomics Data. 12: 58-61.

Nie CH, Wan SM, Tomljanovic T, Treer T, Hsiao CD, Wang WM, Gao ZX*​. 2017. Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development. BMC Genomics. 18: 147. ​

Zhang H, Chang CM, Shen KN, Xian W*, Hsiao CD*. 2016. Identification of myogenic regulatory genes in the muscle transcriptome of beltfish (Trichiurus lepturus): a major commercial marine fish species with robust swimming ability. Genomics Data 8: 81-84.

Chen YC, Hsiao CD*, Lin WD, Hu CM, Hwang PP, Ho JM. 2006. ZooDDD: an inter-species database for DDD analysis. Bioinformatics 22:2180-2182 [*Co-first author]