ZFIN ID: ZDB-PERS-060228-5
Eames, Brian F.
Email: b.frank@usask.ca
URL: https://www.eameslab.ca/
Affiliation: Eames Lab
Address: Department of Anatomy, Physiology, and Pharmacology 2D01-107 Wiggins Rd Saskatoon, SK S7N 5E5 Canada
Country: Canada
Phone: 306-966-6534
ORCID ID: 0000-0002-8200-3760

2017-present: Associate Professor, U Saskatchewan
2012-2017: Assistant Professor, U Saskatchewan
2006-2012: postdoctoral fellow under Charles B. Kimmel, U Oregon
2003-2006: postdoctoral scholar under Richard A. Schneider, UCSF
1998-2003: Ph.D. under Jill A. Helms, UCSF

Research focus:
Development and evolution of vertebrate skeletal tissues

Nguyen, J.K.B., Eames, B.F. (2020) Evolutionary repression of chondrogenic genes in the vertebrate osteoblast. The FEBS journal. 287(20):4354-4361
Desvignes, T., Batzel, P., Sydes, J., Eames, B.F., Postlethwait, J.H. (2019) miRNA analysis with Prost! reveals evolutionary conservation of organ-enriched expression and post-transcriptional modifications in three-spined stickleback and zebrafish. Scientific Reports. 9:3913
Machado, R.G., Eames, B.F. (2017) Using Zebrafish to Test the Genetic Basis of Human Craniofacial Diseases. Journal of dental research. 96(11):1192-1199
Ding, H.L., Hooper, J.E., Batzel, P., Eames, B.F., Postlethwait, J.H., Artinger, K.B., Clouthier, D.E. (2016) MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b. Frontiers in Physiology. 7:281
Hackett, M.J., George, G.N., Pickering, I.J., Eames, B.F. (2016) Chemical Biology in the Embryo: In Situ Imaging of Sulfur Biochemistry in Normal and Proteoglycan-Deficient Cartilage Matrix. Biochemistry. 55(17):2441-51
Brown, D.S., Eames, B.F. (2016) Emerging tools to study proteoglycan function during skeletal development. Methods in cell biology. 134:485-530
Eames, B.F., Delaurier, A., Ullmann, B., Huycke, T.R., Nichols, J.T., Dowd, J., McFadden, M., Sasaki, M.M., and Kimmel, C.B. (2013) FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Developmental Biology. 13(1):23
Huycke, T.R., Eames, B.F., and Kimmel, C.B. (2012) Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development (Cambridge, England). 139(13):2371-2380
Eames, B.F., Amores, A., Yan, Y.L., and Postlethwait, J.H. (2012) Evolution of the osteoblast: Skeletogenesis in gar and zebrafish. BMC Evolutionary Biology. 12(1):27
Eames, B.F., Yan, Y.L., Swartz, M.E., Levic, D.S., Knapik, E.W., Postlethwait, J.H., and Kimmel, C.B. (2011) Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation. PLoS Genetics. 7(8):e1002246
Delaurier, A., Eames, B.F., Blanco-Sánchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis (New York, N.Y. : 2000). 48(8):505-511
Eames, B.F., Singer, A., Smith, G.A., Wood, Z.A., Yan, Y.L., He, X., Polizzi, S.J., Catchen, J.M., Rodriguez-Mari, A., Linbo, T., Raible, D.W., and Postlethwait, J.H. (2010) UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Developmental Biology. 341(2):400-415

1) Eames, BF and RA Schneider (2005). Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development. Development 132(7): 1499-1509.
2) Eames, BF, PT Sharpe, and JA Helms (2004). Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2. Developmental Biology 274(1): 188-200.
3) Eames, BF, and JA Helms (2004). Conserved molecular program regulating cranial and appendicular skeletogenesis. Developmental Dynamics 231(1): 4-13.
4) Miclau T, RA Schneider, BF Eames, and JA Helms (2004). Common molecular mechanisms regulating fetal bone formation and adult fracture repair. W. B. Saunders Company. Philadelphia.
5) Eames, BF, LF de la Fuente, and JA Helms (2003). Molecular ontogeny of the skeleton. Birth Defects Research (Part C) 69:93-101.
6) Eames, BF, DA Benaron, DK Stevenson, and CH Contag (1999). Construction and in vivo testing of a red-emitting firefly luciferase. In: Reporters, Dyes, and Instrumentation. CH Contag, D Bornhop, and E Sevick-Muraca (eds). pp36-39
7) Contag, CH, SD Spilman, PR Contag, M Oshiro, BF Eames, P Dennery, DK Stevenson, and DA Benaron (1997). Visualizing gene expression in living mammals using a bioluminescent reporter. Photochemistry and Photobiology 66(4): 523-31.