ZFIN ID: ZDB-PERS-040907-4
Takamiya, Masanari
Email: masanari.takamiya@kit.edu
URL: http://www.itg.kit.edu
Affiliation: Rastegar Lab
and also: Rastegar/Strähle Lab
Address: Institute of Biological and Chemical Systems - Biological Information Processing Karlsruhe Institute of Technology Postfach 3640 Karlsruhe, D-76021
Country: Germany
Phone: ++49 (0)721 608 28584
Fax: ++49 (0)721 608 23354

In my B.Sc./M.Sc./Ph.D. courses in Japan (1993-1999) and the first postdoc for the next several years (1999-2002), I put all my heart and soul into purifying muscle-derived neurotrophic factors in combination with primary spinal neuron culture. After I spent my whole 20s in the field of applied bio-chemistry, I realized that I was not cut out for 'chemistry' in the first place. I wanted to see the life.

I met with J.A. Campos-Ortega in 2002 and learned embryology. I got overwhelmed by infinite variety of morphological phenotypes caused by transgenetics. His last words to me on his bed of sickness were, 'You should somehow come to a working hypothesis....and try to verify (or falsify, rather) that hypothesis.' This is how he was, always full of energy and thoughtfullness.

I jumped in U. Straehle lab in 2006, since I got absorbed in his idea to connect embryology and adult pathology: cornea project.

Weger, M., Weger, B.D., Schink, A., Takamiya, M., Stegmaier, J., Gobet, C., Parisi, A., Kobitski, A.Y., Mertes, J., Krone, N., Strähle, U., Nienhaus, G.U., Mikut, R., Gachon, F., Gut, P., Dickmeis, T. (2020) MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLIFE. 9:
Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
Kröll-Hermi, A., Ebstein, F., Stoetzel, C., Geoffroy, V., Schaefer, E., Scheidecker, S., Bär, S., Takamiya, M., Kawakami, K., Zieba, B.A., Studer, F., Pelletier, V., Eyermann, C., Speeg-Schatz, C., Laugel, V., Lipsker, D., Sandron, F., McGinn, S., Boland, A., Deleuze, J.F., Kuhn, L., Chicher, J., Hammann, P., Friant, S., Etard, C., Krüger, E., Muller, J., Strähle, U., Dollfus, H. (2020) Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. EMBO Molecular Medicine. 12(7):e11861
Zhang, G., Ferg, M., Lübke, L., Takamiya, M., Beil, T., Gourain, V., Diotel, N., Strähle, U., Rastegar, S. (2020) Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module. Stem Cells. 38(7):875-889
Hayashi, Y., Takamiya, M., Jensen, P.B., Ojea-Jiménez, I., Claude, H., Antony, C., Kjaer-Sorensen, K., Grabher, C., Boesen, T., Gilliland, D., Oxvig, C., Straehle, U., Weiss, C. (2020) Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized In Vivo in Real-Time and at Ultrastructural Resolution. ACS nano. 14(2):1665-1681
Afonin, S., Babii, O., Reuter, A., Middel, V., Takamiya, M., Strähle, U., Komarov, I.V., Ulrich, A.S. (2020) Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos. Beilstein journal of organic chemistry. 16:39-49
Yang, L., Zeng, C., Zhang, Y., Wang, F., Takamiya, M., Strähle, U. (2019) Functions of thioredoxin1 in brain development and in response to environmental chemicals in zebrafish embryos. Toxicology letters. 314:43-52
Gerber, V., Yang, L., Takamiya, M., Ribes, V., Gourain, V., Peravali, R., Stegmaier, J., Mikut, R., Reischl, M., Ferg, M., Rastegar, S., Strähle, U. (2019) The HMG box transcription factors Sox1a and b specify a new class of glycinergic interneurons in the spinal cord of zebrafish embryos. Development (Cambridge, England). 146(4):
Leidner, A., Bauer, J., Ebrahimi Khonachah, M., Takamiya, M., Strähle, U., Dickmeis, T., Rabe, K.S., Niemeyer, C.M. (2019) Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles. Biomaterials. 190-191:76-85
Mane, S.R., Hsiao, I.L., Takamiya, M., Le, D., Straehle, U., Barner-Kowollik, C., Weiss, C., Delaittre, G. (2018) Intrinsically Fluorescent, Stealth Polypyrazoline Nanoparticles with Large Stokes Shift for In Vivo Imaging. Small (Weinheim an der Bergstrasse, Germany). 14(36):e1801571
Schott, B., Traub, M., Schlagenhauf, C., Takamiya, M., Antritter, T., Bartschat, A., Löffler, K., Blessing, D., Otte, J.C., Kobitski, A.Y., Nienhaus, G.U., Strähle, U., Mikut, R., Stegmaier, J. (2018) EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos. PLoS Computational Biology. 14:e1006128
Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
Middel, V., Zhou, L., Takamiya, M., Beil, T., Shahid, M., Roostalu, U., Grabher, C., Rastegar, S., Reischl, M., Nienhaus, G.U., Strähle, U. (2016) Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair. Nature communications. 7:12875
Takamiya, M., Xu, F., Suhonen, H., Gourain, V., Yang, L., Ho, N.Y., Helfen, L., Schröck, A., Etard, C., Grabher, C., Rastegar, S., Schlunck, G., Reinhard, T., Baumbach, T., Strähle, U. (2016) Melanosomes in pigmented epithelia maintain eye lens transparency during zebrafish embryonic development. Scientific Reports. 6:25046
Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016) Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports. 6:23768
Kobitski, A.Y., Otte, J.C., Takamiya, M., Schäfer, B., Mertes, J., Stegmaier, J., Rastegar, S., Rindone, F., Hartmann, V., Stotzka, R., García, A., van Wezel, J., Mikut, R., Strähle, U., Nienhaus, G.U. (2015) An ensemble-averaged, cell density-based digital model of zebrafish embryo development derived from light-sheet microscopy data with single-cell resolution. Scientific Reports. 5:8601
Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
Stegmaier, J., Shahid, M., Takamiya, M., Yang, L., Rastegar, S., Reischl, M., Strähle, U., and Mikut, R. (2014) Automated prior knowledge-based quantification of neuronal patterns in the spinal cord of zebrafish. Bioinformatics (Oxford, England). 30(5):726-33
Ho, N.Y., Yang, L., Legradi, J., Armant, O., Takamiya, M., Rastegar, S., and Strähle, U. (2013) Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environmental science & technology. 47(7):3316-25
Boggetti, B., Jasik, J., Takamiya, M., Strähle, U., Reugels, A.M., and Campos-Ortega, J.A. (2012) NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Developmental Biology. 365(1):164-174
Tschopp, M., Takamiya, M., Cerveny, K.L., Gestri, G., Biehlmaier, O., Wilson, S.W., Strähle, U., and Neuhauss, S.C. (2010) Funduscopy in adult zebrafish and its application to isolate mutant strains with ocular defects. PLoS One. 5(11):e15427
März, M., Chapouton, P., Diotel, N., Vaillant, C., Hesl, B., Takamiya, M., Lam, C.S., Kah, O., Bally-Cuif, L., and Strähle, U. (2010) Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon. Glia. 58(7):870-888
Vinothkumar, S., Rastegar, S., Takamiya, M., Ertzer, R., and Strähle, U. (2008) Sequential and cooperative action of Fgfs and Shh in the zebrafish retina. Developmental Biology. 314(1):200-214
Takamiya, M., and Campos-Ortega, J.A. (2006) Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 235(4):978-997