ZFIN ID: ZDB-PERS-031009-1
Matsui, Jonathan I.
Email: jonathan.matsui@pomona.edu
URL: http://www.biology.pomona.edu/people/faculty/matsui.shtml
Address: Department of Biology and Program in Neuroscience Pomona College 175 W. 6th St. Claremont, CA 91711 USA
Phone: (909) 607-0880
Fax: (909) 621-8878

When sensory receptors in the eye (photoreceptors) and the ear (sensory hair cells) die through environmental stresses (e.g. certain drugs and listening to the iPod too loudly for too long), normal aging and genetics, this often causes irreversible blindness and deafness in humans. By understanding how these sensory receptors die, therapeutics may be designed to prevent their loss. Unfortunately, for one reason or another, this may not be practical. Regenerating these sensory receptors may be needed in order to help restore the lost senses. Non-mammalian vertebrates are capable of regenerating their sensory hair cells so understanding why the zebrafish (Danio rerio) found in many pet stores are capable of regenerating sensory hair cells may lead to therapies and restore the lost senses in humans.

Jacques, B.E., Montgomery, W.H., Uribe, P.M., Yatteau, A., Asuncion, J.D., Resendiz, G., Matsui, J.I., and Dabdoub, A. (2014) The role of Wnt/beta-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line. Developmental Neurobiology. 74(4):438-56
Uribe, P.M., Asuncion, J.D., and Matsui, J.I. (2013) Ethanol affects the development of sensory hair cells in larval zebrafish (Danio rerio). PLoS One. 8(12):e83039
Uribe, P.M., Mueller, M.A., Gleichman, J.S., Kramer, M.D., Wang, Q., Sibrian-Vazquez, M., Strongin, R.M., Steyger, P.S., Cotanche, D.A., and Matsui, J.I. (2013) Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio). PLoS One. 8(2):e55359
Uribe, P.M., Sun, H., Wang, K., Asuncion, J.D., Wang, Q., Chen, C.W., Steyger, P.S., Smith, M.E., and Matsui, J.I. (2013) Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio). PLoS One. 8(3):e58755
Li, Y.N., Matsui, J.I., and Dowling, J.E. (2009) Specificity of the horizontal cell-photoreceptor connections in the zebrafish (Danio rerio) retina. The Journal of comparative neurology. 516(5):442-453
Song, P.I., Matsui, J.I., and Dowling, J.E. (2008) Morphological types and connectivity of horizontal cells found in the adult zebrafish (Danio rerio) retina. The Journal of comparative neurology. 506(2):328-338
Matsui, J.I., Egana, A.L., Sponholtz, T.R., Adolph, A.R., and Dowling, J.E. (2006) Effects of ethanol on photoreceptors and visual function in developing zebrafish. Investigative ophthalmology & visual science. 47(10):4589-4597
Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261

Matsui, J.I., Haque, A., Huss, D., Messana, E.P., Alosi, J.A., Roberson, D.W., Cotanche, D.A., Dickman, J.D., and Warchol, M.E. (2003) Hair Cell Function and Survival Following Aminoglycoside Treatment with Caspase Inhibitors in vivo. Journal of Neuroscience 23:6111-6122.

Matsui, J.I., Ogilvie, J.M., and Warchol, M.E. (2002) Inhibition of Caspases Prevents Ongoing and Ototoxic Hair Cell Death. Journal of Neuroscience 22:1218-1227.

Warchol, M.E., Matsui, J.I., Simkus, E.L., and Ogilvie, J.M. (2001) Ongoing Cell Death and Immune Influences on Cell Division in the Vestibular Sensory Organs. In: Vestibular Labyrinth in Health and Disease (J.A. Goebel and S.M. Highstein, eds.), Annals of the New York Academy of Sciences 942:34-45.

Matsui, J.I., Oesterle, E.C., Stone, J.S., and Rubel, E.W. (2000) Characterization of Damage and Regeneration in Cultured Avian Utricles. Journal of the Association for Research in Otolaryngology 1:46-63.