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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-030925-6
Milan, David J.
Email: dmilan@partners.org
URL:
Affiliation: Milan Lab
Address: Cardiovascular Research Center Massachusetts General Hospital Mailcode 1494100 149 13th Street, 4th Floor Charlestown, MA 02129 USA
Country: United States
Phone: (617) 726-4343
Fax: (617) 726-5806
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Yu, M., Georges, A., Tucker, N.R., Kyryachenko, S., Toomer, K., Schott, J.J., Delling, F.N., Fernandez-Friera, L., Solis, J., Ellinor, P.T., Levine, R.A., Slaugenhaupt, S.A., Hagège, A.A., Dina, C., Jeunemaitre, X., Milan, D.J., Norris, R.A., Bouatia-Naji, N. (2019) Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circulation. Genomic and precision medicine. 12:e002497
Tucker, N.R., Dolmatova, E.V., Lin, H., Cooper, R.R., Ye, J., Hucker, W.J., Jameson, H.S., Parsons, V.A., Weng, L.C., Mills, R.W., Sinner, M.F., Imakaev, M., Leyton-Mange, J., Vlahakes, G., Benjamin, E.J., Lunetta, K.L., Lubitz, S.A., Mirny, L., Milan, D.J., Ellinor, P.T. (2017) Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.. Circulation. Cardiovascular genetics. 10(5)
Lam, P.Y., Mendu, S.K., Mills, R.W., Zheng, B., Padilla, H., Milan, D.J., Desai, B.N., Peterson, R.T. (2017) A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Scientific Reports. 7:11839
Bezzerides, V.J., Zhang, A., Xiao, L., Simonson, B., Khedkar, S.A., Baba, S., Ottaviano, F., Lynch, S., Hessler, K., Rigby, A.C., Milan, D., Das, S., Rosenzweig, A. (2017) Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Scientific Reports. 7:346
Kiando, S.R., Tucker, N.R., Castro-Vega, L.J., Katz, A., D'Escamard, V., Tréard, C., Fraher, D., Albuisson, J., Kadian-Dodov, D., Ye, Z., Austin, E., Yang, M.L., Hunker, K., Barlassina, C., Cusi, D., Galan, P., Empana, J.P., Jouven, X., Gimenez-Roqueplo, A.P., Bruneval, P., Hyun Kim, E.S., Olin, J.W., Gornik, H.L., Azizi, M., Plouin, P.F., Ellinor, P.T., Kullo, I.J., Milan, D.J., Ganesh, S.K., Boutouyrie, P., Kovacic, J.C., Jeunemaitre, X., Bouatia-Naji, N. (2016) PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance. PLoS Genetics. 12:e1006367
Kiando, S., Tucker, N., Castro-Vega, L., Cusi, D., Galan, P., J-P, E., Olin, J., Gornik, H., Plouin, P.F., Kullo, I., Milan, D., Ganesh, S., Boutouyrie, P., Kovacic, J., Jeunemaitre, X., Bouatia-Naji, N. (2016) Genetic association study identifies common variation in phactr1 to associate with fibromuscular dysplasia. Journal of hypertension. 34 Suppl 2 - ESH 2016 Abstract Book:e91
Wang, X., Tucker, N.R., Rizki, G., Mills, R., Krijger, P.H., de Wit, E., Subramanian, V., Bartell, E., Nguyen, X.X., Ye, J., Leyton-Mange, J., Dolmatova, E.V., van der Harst, P., de Laat, W., Ellinor, P.T., Newton-Cheh, C., Milan, D.J., Kellis, M., Boyer, L.A. (2016) Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures. eLIFE. 5
Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., PROMESA investigators, Le Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M., Hercberg, S., Roussel, R., Benjamin, E.J., Bonnet, F., Lo, S.H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R., Le Marec, H., Froguel, P., Ellinor, P.T., Vasan, R.S., Bruneval, P., Markwald, R.R., Norris, R.A., Milan, D.J., Slaugenhaupt, S.A., Levine, R.A., Schott, J.J., Hagege, A.A., Mvp-France, Jeunemaitre, X., Leducq Transatlantic MITRAL Network (2015) Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nature Genetics. 47(10):1206-11
Lundby, A., Rossin, E.J., Steffensen, A.B., Acha, M.R., Newton-Cheh, C., Pfeufer, A., Lynch, S.N., QT Interval International GWAS Consortium (QT-IGC), Olesen, S.P., Brunak, S., Ellinor, P.T., Jukema, J.W., Trompet, S., Ford, I., Macfarlane, P.W., Krijthe, B.P., Hofman, A., Uitterlinden, A.G., Stricker, B.H., Nathoe, H.M., Spiering, W., Daly, M.J., Asselbergs, F.W., van der Harst, P., Milan, D.J., de Bakker, P.I., Lage, K., Olsen, J.V. (2014) Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nature Methods. 11(8):868-74
Kolpa, H.J., Peal, D.S., Lynch, S.N., Giokas, A.C., Ghatak, S., Misra, S., Norris, R.A., MacRae, C.A., Markwald, R.R., Ellinor, P., Bischoff, J., and Milan, D.J. (2013) miR-21 represses Pdcd4 during cardiac valvulogenesis. Development (Cambridge, England). 140(10):2172-80
Kokel, D., Cheung, C.Y., Mills, R., Coutinho-Budd, J., Huang, L., Setola, V., Sprague, J., Jin, S., Jin, Y.N., Huang, X.P., Bruni, G., Woolf, C.J., Roth, B.L., Hamblin, M.R., Zylka, M.J., Milan, D.J., and Peterson, R.T. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nature Chemical Biology. 9(4):257-263
Peal, D.S., Lynch, S.N., and Milan, D.J. (2011) Patterning and Development of the Atrioventricular Canal in Zebrafish. Journal of cardiovascular translational research. 4(6):720-6
Peal, D.S., Mills, R.W., Lynch, S.N., Mosley, J.M., Lim, E., Ellinor, P.T., January, C.T., Peterson, R.T., and Milan, D.J. (2011) Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen. Circulation. 123(1):23-30
Peal, D.S., Peterson, R.T., and Milan, D. (2010) Small Molecule Screening in Zebrafish. Journal of cardiovascular translational research. 3(5):454-460
Peal, D.S., Burns, C.G., MacRae, C.A., and Milan, D. (2009) Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Developmental dynamics : an official publication of the American Association of Anatomists. 238(12):3103-3110
Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
Milan, D.J., and MacRae, C.A. (2008) Zebrafish genetic models for arrhythmia. Progress in Biophysics and Molecular Biology. 98(2-3):301-308
Milan, D.J., Jones, I.L., Ellinor, P.T., and MacRae, C.A. (2006) In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. American journal of physiology. Heart and circulatory physiology. 291(1):H269-H273
Milan, D.J., Giokas, A.C., Serluca, F.C., Peterson, R.T., and MacRae, C.A. (2006) Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (Cambridge, England). 133(6):1125-1132
Burns, C.G., Milan, D.J., Grande, E.J., Rottbauer, W., MacRae, C.A., and Fishman, M.C. (2005) High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nature Chemical Biology. 1(5):263-264
Peterson, R.T., Shaw, S.Y., Peterson, T.A., Milan, D.J., Zhong, T.P., Schreiber, S.L., MacRae, C.A., and Fishman, M.C. (2004) Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat. Biotechnol.. 22(5):595-599

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