ZFIN ID: ZDB-PERS-030730-4
Janz, David M.
Email: david.janz@usask.ca
Address: Dept. of Veterinary Biomedical Sciences and Toxicology Centre University of Saskatchewan 52 Campus Drive Saskatoon, SK, S7N 5B4 Canada
Phone: 306-966-7434
Fax: 306-966-7376

Dr. Janz's research generally involves investigating interactions between physiological control and environmental alteration of developmental and reproductive processes in vertebrates, particularly fishes. The goal of his research is to investigate relationships between biological responses at the molecular and cellular levels with those occurring at the organ, organism and population levels in animals exposed to environmental stressors. This is achieved by combining physiological, cell biological, pharmacological and molecular biological approaches in the laboratory with ecological approaches in the field. Recent work has focused on investigating biochemical mechanisms of action of toxicants on ovarian and testicular physiology using fish as an experimental model.

Gerhart, A.K., Janz, D.M. (2019) Toxicity of Aqueous L-Selenomethionine and Tert-Butyl Hydroperoxide Exposure to Zebrafish (Danio rerio) Embryos Following Tert-Butyl Hydroquinone Treatment. Toxics. 7(3)
Gerhart, A.K., Hecker, M., Janz, D.M. (2019) Toxicity of Aqueous L-Selenomethionine Exposure to Early Life-Stages of the Fathead Minnow (Pimephales promelas). Bulletin of environmental contamination and toxicology. 102(3):323-328
Pettem, C.M., Weber, L.P., Janz, D.M. (2017) Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 159:449-460
Raine, J.C., Lallemand, L., Pettem, C.M., Janz, D.M. (2016) Effects of Chronic Dietary Selenomethionine Exposure on the Visual System of Adult and F1 Generation Zebrafish (Danio rerio). Bulletin of environmental contamination and toxicology. 97(3):331-6
Thomas, J.K., Janz, D.M. (2016) Embryo Microinjection of Selenomethionine Reduces Hatchability and Modifies Oxidant Responsive Gene Expression in Zebrafish. Scientific Reports. 6:26520
Choudhury, S., Thomas, J.K., Sylvain, N.J., Ponomarenko, O., Gordon, R.A., Heald, S.M., Janz, D.M., Krone, P.H., Coulthard, I., George, G.N., Pickering, I.J. (2015) Selenium preferentially accumulates in the eye lens following embryonic exposure: a confocal X-ray fluorescence imaging study. Environmental science & technology. 49(4):2255-61
Gerger, C.J., Thomas, J.K., Janz, D.M., Weber, L.P. (2015) Acute effects of β-naphthoflavone on cardiorespiratory function and metabolism in adult zebrafish (Danio rerio). Fish physiology and biochemistry. 41(1):289-98
Thomas, J.K., Janz, D.M. (2014) In ovo exposure to selenomethionine via maternal transfer increases developmental toxicities and impairs swim performance in F1 generation zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 152C:20-29
Thomas, J.K., Wiseman, S., Giesy, J.P., and Janz, D.M. (2013) Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 130-131C:112-122
Masse, A., Thomas, J.K., and Janz, D.M. (2013) Reduced Swim Performance and Aerobic Capacity in Adult Zebrafish Exposed To Waterborne Selenite. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 157(3):266-271
Thomas, J.K., and Janz, D.M. (2011) Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response. Aquatic toxicology (Amsterdam, Netherlands). 102(1-2):79-86
Lin, L.L., and Janz, D.M. (2006) Effects of binary mixtures of xenoestrogens on gonadal development and reproduction in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 80(4):382-395
Weber, L.P., Hill, R.L., and Janz, D.M. (2003) Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity. Aquatic toxicology (Amsterdam, Netherlands). 63(4):431-446
Hill, R.L. and Janz, D.M. (2003) Developmental estrogenic exposure in zebrafish (Danio rerio): I. Effects on sex ratio and breeding success. Aquatic toxicology (Amsterdam, Netherlands). 63(4):417-429