ZFIN ID: ZDB-PERS-030312-4
Lescure, Alain
Email: a.lescure@ibmc.u-strasbg.fr
URL: http://www-ibmc.u-strasbg.fr/upr9002/krol/En/equipe.html
Affiliation:
Address: Structure des Macromolécules Biologiques et Mécanismes de Reconnaissance Unité Propre de Recherche 9002 Centre National de la Recherche Scientifique Institut de Biologie Moleculaire et Cellulaire 15, rue René Descartes Strasbourg , 67084 France
Country:
Phone: 33-3-88-41-70-69 or 80
Fax: 33-3-88-60-22-18
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
The scientific interest of our team concerns the elucidation of the biological and physiological role of the essential trace element selenium.
Selenium deficiencies can lead to various pathologies such as ageing, cardiomyopathies, increased succeptibility to cancers, male infertility. Selenocysteine, the major biological form of selenium, is considered to be the 21st amino acid and is cotranslationally incorporated into the active site of selenoproteins. These pleiotropic defects reflect the functional diversity of the selenoproteins, enzymes involved in a variety of redox pathways: reduction of reactive oxygen species and oxydized bio-molecules, maturation of the thyroid hormone, several reactions involved in sperm maturation. Besides, it was shown that patients carrying mutations in the gene encoding a recently discovered selenoprotein, develop a congenital muscular dystrophy.
Considering the obvious biomedical interest of selenoproteins, an important aspect of our research efforts is devoted to uncovering novel selenoproteins in eukaryotic genomes and to elucidating their function.


PUBLICATIONS
Castets, P., Lescure, A., Guicheney, P., and Allamand, V. (2012) Selenoprotein N in skeletal muscle: from diseases to function. Journal of molecular medicine (Berlin, Germany). 90(10):1095-1107
Deniziak, M., Thisse, C., Rederstorff, M., Hindelang, C., Thisse, B., and Lescure, A. (2007) Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Experimental cell research. 313(1):156-167
Castellano, S., Lobanov, A.V., Chapple, C., Novoselov, S.V., Albrecht, M., Hua, D., Lescure, A., Lengauer, T., Krol, A., Gladyshev, V.N., and Guigo, R. (2005) Diversity and functional plasticity of eukaryotic selenoproteins: Identification and characterization of the SelJ family. Proc Natl Acad Sci U S A. 2002. 102(45):16188-16193
Castellano, S., Novoselov, S.V., Kryukov, G.V., Lescure, A., Blanco, E., Krol, A., Gladyshev, V.N., and Guigo, R. (2004) Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO reports. 5(1):71-77
Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene expression patterns : GEP. 3(4):525-532
Fagegaltier, D., Lescure, A., Walczak, R., Carbon, P., and Krol, A. (2000) Structural analysis of new local features in SECIS RNA hairpins. Nucleic acids research. 28(14):2679-2689

NON-ZEBRAFISH PUBLICATIONS