ZFIN ID: ZDB-PERS-021220-2
Wong, Rachel
Email: wongr2@u.washington.edu
URL: http://thalamus.wustl.edu/Neuroweb/wong.htm
Affiliation: Wong Lab
Address: Department of Biological Structure University of Washington HSB G514, Box 357420 Seattle, WA 98195-7420 USA
Country: United States
Phone: (206) 616 3275
Fax: (206) 543-1524

Professor of Biological Structure

Research Interests: I am interested in how neurons in the central nervous system are wired up accurately during development. Using live imaging techniques, together with electrophysiology and molecular approaches, my lab. has been investigating how neural circuits are specified in the vertebrate visual system. Our studies in mammalian and chick retina have encouraged us to pursue an in vivo analysis of the development of synaptic layers in the zebrafish retina.

Nunley, H., Nagashima, M., Martin, K., Lorenzo Gonzalez, A., Suzuki, S.C., Norton, D.A., Wong, R.O.L., Raymond, P.A., Lubensky, D.K. (2020) Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation. PLoS Computational Biology. 16:e1008437
D'Orazi, F.D., Suzuki, S.C., Darling, N., Wong, R.O., Yoshimatsu, T. (2020) Conditional and biased regeneration of cone photoreceptor types in the zebrafish retina. The Journal of comparative neurology. 528(17):2816-2830
Yu, W.Q., El-Danaf, R.N., Okawa, H., Pacholec, J.M., Matti, U., Schwarz, K., Odermatt, B., Dunn, F.A., Lagnado, L., Schmitz, F., Huberman, A.D., Wong, R.O.L. (2018) Synaptic Convergence Patterns onto Retinal Ganglion Cells Are Preserved despite Topographic Variation in Pre- and Postsynaptic Territories. Cell Reports. 25:2017-2026.e3
Jorstad, N.L., Wilken, M.S., Grimes, W.N., Wohl, S.G., VandenBosch, L.S., Yoshimatsu, T., Wong, R.O., Rieke, F., Reh, T.A. (2017) Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature. 548(7665):103-107
D'Orazi, F.D., Zhao, X.F., Wong, R.O., Yoshimatsu, T. (2016) Mismatch of Synaptic Patterns between Neurons Produced in Regeneration and during Development of the Vertebrate Retina. Current biology : CB. 26(17):2268-79
Yoshimatsu, T., D'Orazi, F.D., Gamlin, C.R., Suzuki, S.C., Suli, A., Kimelman, D., Raible, D.W., Wong, R.O. (2016) Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. Nature communications. 7:10590
Hoon, M., Okawa, H., Della Santina, L., Wong, R.O. (2014) Functional Architecture of the Retina: Development and Disease. Progress in Retinal and Eye Research. 42C:44-84
Yoshimatsu, T., Williams, P.R., D'Orazi, F.D., Suzuki, S.C., Fadool, J.M., Allison, W.T., Raymond, P.A., Wong, R.O. (2014) Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells. Nature communications. 5:3699
Suzuki, S.C., Bleckert, A., Williams, P.R., Takechi, M., Kawamura, S., and Wong, R.O. (2013) Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors. Proceedings of the National Academy of Sciences of the United States of America. 110(37):15109-14
Randlett, O., MacDonald, R.B., Yoshimatsu, T., Almeida, A.D., Suzuki, S.C., Wong, R.O., Harris, W.A. (2013) Cellular requirements for building a retinal neuropil. Cell Reports. 3:282-90
Williams, P.R., Morgan, J.L., Kerschensteiner, D., and Wong, R.O. (2013) In vivo imaging of zebrafish retina. Cold Spring Harbor protocols. 2013(1):4671-80
Choi, J.H., Law, M.Y., Chien, C.B., Link, B.A., and Wong, R.O. (2010) In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. Neural Development. 5:29
Williams, P.R., Suzuki, S.C., Yoshimatsu, T., Lawrence, O.T., Waldron, S.J., Parsons, M.J., Nonet, M.L., and Wong, R.O. (2010) In vivo development of outer retinal synapses in the absence of glial contact. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(36):11951-11961
Mumm, J.S., Williams, P.R., Godinho, L., Koerber, A., Pittman, A.J., Roeser, T., Chien, C.B., Baier, H., and Wong, R.O. (2006) In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron. 52(4):609-621
Schroeter, E.H., Wong, R.O., and Gregg, R.G. (2006) In vivo development of retinal ON-bipolar cell axonal terminals visualized in nyx::MYFP transgenic zebrafish. Visual neuroscience. 23(5):833-843
Morris, A.C., Schroeter, E.H., Bilotta, J., Wong, R.O., and Fadool, J.M. (2005) Cone Survival Despite Rod Degeneration in XOPS-mCFP Transgenic Zebrafish. Investigative ophthalmology & visual science. 46(12):4762-4771
Godinho, L., Mumm, J.S., Williams, P.R., Schroeter, E.H., Koerber, A., Park, S.W., Leach, S.D., and Wong, R.O. (2005) Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina. Development (Cambridge, England). 132(22):5069-5079

Lohmann, C., Myhr, K.L. and Wong, R.O.L. (2002) Transmitter-evoked local calcium release stabilizes developing dendrites. Nature 418:177-181.

Wong, R.O.L. and Ghosh, A. (2002) Regulation of dendritic growth and patterning by neuronal calcium signaling. Nature Rev. Neurosci. 3: 803-812.

Wong, R.O.L. and Lichtman, J.W. (2002) Synapse Elimination. In: Fundamental Neuroscience, Zigmond, M.J., Bloom, F.E., Landis, S.C., Roberts, J.L. and Squire, L.R. (eds.), pp 533-554, Academic Press, San Diego.