Person
Peng, Gang
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Biography and Research Interest
Gang Peng is a Principal Investigator at the Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University. He received his B.Sc. degree in Peking University in 1996 and his Ph.D. degree in Biochemistry and Molecular Biology from PennState University in 2002. He was a postdoctoral research associate in Dr. Monte Westerfield?s laboratory in the Institute of Neuroscience in the University of Oregon between 2002 and 2008. He joined the Institutes of Brain Science and the State Key Laboratory of Medical Neurobiology, Fudan University in 2008.
Our research has been focused on the molecular mechanisms underlying nervous system development and behavior in the zebrafish Danio rerio. The long term goal of his research is two-fold: to determine how external stimuli are processed by the neural circuits in the zebrafish brain to direct its adaptive behaviors; and to learn how the central neural circuits responsible for these behaviors are specified genetically and molecularly. In addition, his research group is generating zebrafish models of nervous system diseases and mental disorders, with the goal to provide novel routes for the understanding of the genetic underpinnings and the treatment of those diseases.
Our research has been focused on the molecular mechanisms underlying nervous system development and behavior in the zebrafish Danio rerio. The long term goal of his research is two-fold: to determine how external stimuli are processed by the neural circuits in the zebrafish brain to direct its adaptive behaviors; and to learn how the central neural circuits responsible for these behaviors are specified genetically and molecularly. In addition, his research group is generating zebrafish models of nervous system diseases and mental disorders, with the goal to provide novel routes for the understanding of the genetic underpinnings and the treatment of those diseases.
- Li, Y., Zhang, C., Peng, G. (2023) Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 83(8):753-764
- Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:
- Guo, S., Gao, G., Zhang, C., Peng, G. (2022) Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Veterinary sciences. 9(2):
- Wang, J., Yan, H.B., Zhang, Q., Liu, W.Y., Jiang, Y.H., Peng, G., Wu, F.Z., Liu, X., Yang, P.Y., Liu, F. (2021) Enhancement of E-cadherin expression and processing and driving of cancer cell metastasis by ARID1A deficiency. Oncogene. 40(36):5468-5481
- Wang, T., Zhou, M., Zhang, Q., Zhang, C., Peng, G. (2021) ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish. Neuroscience Bulletin. 37(12):1658-1670
- Zhang, W., Li, Y., Chen, S., Zhang, C., Chen, L., Peng, G. (2021) nr0b1 (DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation. Journal of genetics and genomics = Yi chuan xue bao. 49(3):217-229
- Zhou, Q., Lei, L., Zhang, H., Chiu, S.C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., Xiong, J.W. (2021) Proprotein Convertase Furina Is Required for Heart Development in Zebrafish. Journal of Cell Science. 134(21):
- Kan, Y., Meng, L., Xie, L., Liu, L., Dong, W., Feng, J., Yan, Y., Zhao, C., Peng, G., Wang, D., Lu, M., Yang, C., Niu, C. (2019) Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection. Fish & shellfish immunology. 96:78-85
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Liu, T., Shi, Y., Chan, M.T.V., Peng, G., Zhang, Q., Sun, X., Zhu, Z., Xie, Y., Sham, K.W.Y., Li, J., Liu, X., Ho, I.H.T., Gin, T., Lu, Z., Wu, W.K.K., Cheng, C.H.K. (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Translational psychiatry. 8:232
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