ZFIN ID: ZDB-PERS-020809-3
Hadzhiev, Yavor
Email: y.hadzhiev@bham.ac.uk
Affiliation: Ferenc Müller Lab
Address: IBR West, Level 1 School of Clinical and Experimental Medicine College of Medical and Dental Sciences University of Birmingham Birmingham, B15 2TT
Country: United Kingdom
Phone: +44 121 414 4529


Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F. (2023) The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation. Developmental Cell. 58:155170.e8155-170.e8
Dix, T., Haussmann, I., Brivio, S., Nallasivan, M., Hadzhiev, Y., Muller, F., Pettitt, J., Müller, B., Soller, M. (2022) CMTr mediated 2`-O-ribose methylation status of cap adjacent-nucleotides across animals. RNA (New York, N.Y.). 28(10):1377-1390
D'Orazio, F.M., Balwierz, P.J., González, A.J., Guo, Y., Hernández-Rodríguez, B., Wheatley, L., Jasiulewicz, A., Hadzhiev, Y., Vaquerizas, J.M., Cairns, B., Lenhard, B., Müller, F. (2021) Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization. Developmental Cell. 56(5):641-656.e5
D'Orazio, F.M., Jasiulewicz, A., Hadzhiev, Y., Müller, F. (2021) Visualization of Transcriptional Activity in Early Zebrafish Primordial Germ Cells. Methods in molecular biology (Clifton, N.J.). 2218:185-194
Nepal, C., Hadzhiev, Y., Balwierz, P., Tarifeño-Saldivia, E., Cardenas, R., Wragg, J.W., Suzuki, A.M., Carninci, P., Peers, B., Lenhard, B., Andersen, J.B., Müller, F. (2020) Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing. Nature communications. 11:168
Hadzhiev, Y., Qureshi, H.K., Wheatley, L., Cooper, L., Jasiulewicz, A., Van Nguyen, H., Wragg, J.W., Poovathumkadavil, D., Conic, S., Bajan, S., Sik, A., Hutvàgner, G., Tora, L., Gambus, A., Fossey, J.S., Müller, F. (2019) A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation. Nature communications. 10:691
Bakos, K., Kovacs, R., Balogh, E., Sipos, D.K., Reining, M., Gyomorei-Neuberger, O., Balazs, A., Kriszt, B., Bencsik, D., Csepeli, A., Gazsi, G., Hadzhiev, Y., Urbanyi, B., Mueller, F., Kovacs, B., Csenki, Z. (2019) Estrogen sensitive liver transgenic zebrafish (Danio rerio) line (Tg(vtg1:mCherry)) suitable for the direct detection of estrogenicity in environmental samples. Aquatic toxicology (Amsterdam, Netherlands). 208:157-167
Dong, X., Liao, Z., Gritsch, D., Hadzhiev, Y., Bai, Y., Locascio, J.J., Guennewig, B., Liu, G., Blauwendraat, C., Wang, T., Adler, C.H., Hedreen, J.C., Faull, R.L.M., Frosch, M.P., Nelson, P.T., Rizzu, P., Cooper, A.A., Heutink, P., Beach, T.G., Mattick, J.S., Müller, F., Scherzer, C.R. (2018) Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience. 21(10):1482-1492
Basu, S., Hadzhiev, Y., Petrosino, G., Nepal, C., Gehrig, J., Armant, O., Ferg, M., Strahle, U., Sanges, R., Müller, F. (2016) The Tetraodon nigroviridis reference transcriptome: developmental transition, length retention and microsynteny of long non-coding RNAs in a compact vertebrate genome. Scientific Reports. 6:33210
Kenyon, E.J., Luijten, M.N., Gill, H., Li, N., Rawlings, M., Bull, J.C., Hadzhiev, Y., van Steensel, M.A., Maher, E., Mueller, F. (2016) Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Developmental Biology. 16:23
Nepal, C., Coolen, M., Hadzhiev, Y., Cussigh, D., Mydel, P., Steen, V.M., Carninci, P., Andersen, J.B., Bally-Cuif, L., Müller, F., Lenhard, B. (2016) Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs. Nucleic acids research. 44(7):3070-81
Hadzhiev, Y., Miguel-Escalada, I., Balciunas, D., Müller, F. (2016) Testing of Cis-Regulatory Elements by Targeted Transgene Integration in Zebrafish Using PhiC31 Integrase. Methods in molecular biology (Clifton, N.J.). 1451:81-91
Zaucker, A., Bodur, T., Roest Crollius, H., Hadzhiev, Y., Gehrig, J., Loosli, F., Watson, C., Müller, F. (2014) Description of Embryonic Development of Spotted Green Pufferfish (Tetraodon nigroviridis). Zebrafish. 11(6):509-17
Haberle, V., Li, N., Hadzhiev, Y., Plessy, C., Previti, C., Nepal, C., Gehrig, J., Dong, X., Akalin, A., Suzuki, A.M., van IJcken, W.F., Armant, O., Ferg, M., Strähle, U., Carninci, P., Müller, F., and Lenhard, B. (2014) Two independent transcription initiation codes overlap on vertebrate core promoters. Nature. 507(7492):381-385
Roberts, J.A., Miguel-Escalada, I., Slovik, K.J., Walsh, K.T., Hadzhiev, Y., Sanges, R., Stupka, E., Marsh, E.K., Balciuniene, J., Balciunas, D., and Müller, F. (2014) Targeted transgene integration overcomes variability of position effects in zebrafish. Development (Cambridge, England). 141(3):715-724
Nepal, C., Hadzhiev, Y., Previty, C., Haberle, V., Li, N., Takahashi, H., Suzuki, A.M., Sheng, Y., Abdelhamid, R., Anand, S., Gehrig, J., Akalin, A., Kockx, C., van der Sloot, A., van Ijcken, W., Armant, O., Rastegar, S., Straehle, U., Stupka, E., Carninci, P., Lenhard, B., and Muller, F. (2013) Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis. Genome research. 23(11):1938-50
Parajes, S., Griffin, A., Taylor, A.E., Rose, I.T., Miguel-Escalada, I., Hadzhiev, Y., Arlt, W., Shackleton, C., Muller, F., and Krone, N. (2013) Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme Cyp11a2. Endocrinology. 154(8):2702-11
Sanges, R., Hadzhiev, Y., Gueroult-Bellone, M., Roure, A., Ferg, M., Meola, N., Amore, G., Basu, S., Brown, E.R., De Simone, M., Petrera, F., Licastro, D., Strahle, U., Banfi, S., Lemaire, P., Birney, E., Muller, F., and Stupka, E. (2013) Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during development. Nucleic acids research. 41(6):3600-3618
Peravali, R., Gehrig, J., Giselbrecht, S., Lutjohann, D.S., Hadzhiev, Y., Muller, F., and Liebel, U. (2011) Automated feature detection and imaging for high-resolution screening of zebrafish embryos. Biotechniques. 50(5):319-324
Bem, D., Yoshimura, S., Nunes-Bastos, R., Bond, F.F., Kurian, M.A., Rahman, F., Handley, M.T., Hadzhiev, Y., Masood, I., Straatman-Iwanowska, A.A., Cullinane, A.R., McNeill, A., Pasha, S.S., Kirby, G.A., Foster, K., Ahmed, Z., Morton, J.E., Williams, D., Graham, J.M., Dobyns, W.B., Burglen, L., Ainsworth, J.R., Gissen, P., Muller, F., Maher, E.R., Barr, F.A., and Aligianis, I.A. (2011) Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome. American journal of human genetics. 88(4):499-507
Lang, M., Hadzhiev, Y., Siegel, N., Amemiya, C.T., Parada, C., Strähle, U., Becker, M.B., Muller, F., and Meyer, A. (2010) Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position. EvoDevo. 1(1):11
Kano, S., Xiao, J.H., Osorio, J., Ekker, M., Hadzhiev, Y., Muller, F., Casane, D., Magdelenat, G., and Retaux, S. (2010) Two lamprey hedgehog genes share non-coding regulatory sequences and expression patterns with gnathostome hedgehogs. PLoS One. 5(10):e13332
Csenki, Z., Zaucker, A., Kovacs, B., Hadzhiev, Y., Hegyi, R., Lefler, K.K., Muller, T., Kovacs, R., Urbanyi, B., Varadi, L., and Muller, F. (2010) Intraovarian transplantation of stage I-II follicles results in viable zebrafish embryos. The International journal of developmental biology. 54(4):585-589
Gehrig, J., Reischl, M., Kalmar, E., Ferg, M., Hadzhiev, Y., Zaucker, A., Song, C., Schindler, S., Liebel, U., and Muller, F. (2009) Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nature Methods. 6(12):911-916
Rastegar, S., Hess, I., Dickmeis, T., Nicod, J.C., Ertzer, R., Hadzhiev, Y., Thies, W.G., Scherer, G., and Strähle, U. (2008) The words of the regulatory code are arranged in a variable manner in highly conserved enhancers. Developmental Biology. 318(2):366-377
Hadzhiev, Y., Lele, Z., Schindler, S., Wilson, S.W., Ahlberg, P., Straehle, U., and Mueller, F. (2007) Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Developmental Biology. 7(1):75
Ertzer, R., Muller, F., Hadzhiev, Y., Rathnam, S., Fischer, N., Rastegar, S., and Strähle, U. (2007) Cooperation of sonic hedgehog enhancers in midline expression. Developmental Biology. 301(2):578-589
Bartfai, R., Balduf, C., Hilton, T., Rathmann, Y., Hadzhiev, Y., Tora, L., Orbán, L., and Muller, F. (2004) TBP2, a Vertebrate-Specific Member of the TBP Family, Is Required in Embryonic Development of Zebrafish. Current biology : CB. 14(7):593-598