ZFIN ID: ZDB-PERS-020807-4
Osborn, Dan
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URL:
Affiliation:
Address: MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics King's College London 4th Floor South New Hunt's House Guy's Campus London, SE1 1UL United Kingdom
Country:
Phone: 44-20-7848-6445
Fax: 44-20-7848-6798
ORCID ID: 0000-0002-5266-404X


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
Kolatsi-Joannou, M., Osborn, D. (2020) A Technique for Studying Glomerular Filtration Integrity in the Zebrafish Pronephros. Methods in molecular biology (Clifton, N.J.). 2067:25-39
Wagner, M., Osborn, D.P.S., Gehweiler, I., Nagel, M., Ulmer, U., Bakhtiari, S., Amouri, R., Boostani, R., Hentati, F., Hockley, M.M., Hölbling, B., Schwarzmayr, T., Karimiani, E.G., Kernstock, C., Maroofian, R., Müller-Felber, W., Ozkan, E., Padilla-Lopez, S., Reich, S., Reichbauer, J., Darvish, H., Shahmohammadibeni, N., Tafakhori, A., Vill, K., Zuchner, S., Kruer, M.C., Winkelmann, J., Jamshidi, Y., Schüle, R. (2019) Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia. Nature communications. 10:4790
Osborn, D.P., Pond, H.L., Mazaheri, N., Dejardin, J., Munn, C.J., Mushref, K., Cauley, E.S., Moroni, I., Pasanisi, M.B., Sellars, E.A., Hill, R.S., Partlow, J.N., Willaert, R.K., Bharj, J., Malamiri, R.A., Galehdari, H., Shariati, G., Maroofian, R., Mora, M., Swan, L.E., Voit, T., Conti, F.J., Jamshidi, Y., Manzini, M.C. (2017) Mutations in INPP5K Cause a Form of Congenital Muscular Dystrophy Overlapping Marinesco-Sjögren Syndrome and Dystroglycanopathy. American journal of human genetics. 100(3):537-545
Marshall, R.A., Osborn, D.P. (2016) Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function. Cilia. 5:16
Christou-Savina, S., Beales, P.L., Osborn, D.P. (2015) Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay. Journal of visualized experiments : JoVE. (96):e52540
Osborn, D.P., Roccasecca, R.M., McMurray, F., Hernandez-Hernandez, V., Mukherjee, S., Barroso, I., Stemple, D., Cox, R., Beales, P.L., and Christou-Savina, S. (2014) Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. PLoS One. 9(2):e87662
Cardenas-Rodriguez, M., Osborn, D.P., Irigoín, F., Graña, M., Romero, H., Beales, P.L., and Badano, J.L. (2013) Characterization of CCDC28B reveals its role in ciliogenesis and provides insight to understand its modifier effect on Bardet-Biedl syndrome. Human genetics. 132(1):91-105
Prodromou, N.V., Thompson, C., Osborn, D.P., Cogger, K.F., Ashworth, R., Knight, M.M., Beales, P.L., and Chapple, J.P. (2012) Heat shock induces rapid resorption of primary cilia. Journal of Cell Science. 125(18):4297-4305
Rooryck, C., Diaz-Font, A., Osborn, D.P., Chabchoub, E., Hernandez-Hernandez, V., Shamseldin, H., Kenny, J., Waters, A., Jenkins, D., Kaissi, A.A., Leal, G.F., Dallapiccola, B., Carnevale, F., Bitner-Glindzicz, M., Lees, M., Hennekam, R., Stanier, P., Burns, A.J., Peeters, H., Alkuraya, F.S., and Beales, P.L. (2011) Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nature Genetics. 43(3):197-203
Osborn, D.P., Li, K., Hinits, Y., and Hughes, S.M. (2011) Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Developmental Biology. 350(2):464-475
May-Simera, H.L., Kai, M., Hernandez, V., Osborn, D.P., Tada, M., and Beales, P.L. (2010) Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. Developmental Biology. 345(2):215-225
Walczak-Sztulpa, J., Eggenschwiler, J., Osborn, D., Brown, D.A., Emma, F., Klingenberg, C., Hennekam, R.C., Torre, G., Garshasbi, M., Tzschach, A., Szczepanska, M., Krawczynski, M., Zachwieja, J., Zwolinska, D., Beales, P.L., Ropers, H.H., Latos-Bielenska, A., and Kuss, A.W. (2010) Cranioectodermal Dysplasia, Sensenbrenner Syndrome, Is a Ciliopathy Caused by Mutations in the IFT122 Gene. American journal of human genetics. 86(6):949-956
Pearson, C.G., Osborn, D.P., Giddings, T.H. Jr, Beales, P.L., and Winey, M. (2009) Basal body stability and ciliogenesis requires the conserved component Poc1. The Journal of cell biology. 187(6):905-920
Hinits, Y., Osborn, D.P., and Hughes, S.M. (2009) Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations. Development (Cambridge, England). 136(3):403-414
Mann, C.J., Osborn, D.P., and Hughes, S.M. (2007) Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord. Gene expression patterns : GEP. 7(8):827-836
Hinits, Y., Osborn, D.P., Carvajal, J.J., Rigby, P.W., and Hughes, S.M. (2007) Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle. Gene expression patterns : GEP. 7(7):738-745
Hammond, C.L., Hinits, Y., Osborn, D.P., Minchin, J.E., Tettamanti, G., and Hughes, S.M. (2007) Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish. Developmental Biology. 302(2):504-521

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