Person
Raya, Angel
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Biography and Research Interest
2020-present Coordinator, Regenerative Medicine Program at Bellvitge Biomedical Research Institute (IDIBELL).
2017-present Director, Program for Translation of Regenerative Medicine in Catalonia (P-CMRC).
2014-2019: Director, Center of Regenerative Medicine in Barcelona, Barcelona, Spain.
2010-2015: Group Leader, Institute for Bioengineering of Catalonia, Barcelona Science Park, Barcelona, Spain.
2008-present: Group Leader, Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN).
2006-2009: Scientific Coordinator, Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain.
2006-present: ICREA Research Professor.
2004-2006: Senior Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
2000-2004: Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
1999-2000: Senior Research Associate. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1996: Assistant Professor. Department of Physiology, University of Valencia, Spain.
1995-1999: Postdoctoral Research Fellow. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1994-1995: Special Project Associate. Peripheral Nerve Center, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Supervisor: Phillip A. Low.
1991-1995: Graduate student. Department of Physiology, University of Valencia, Spain. Supervisor: Joaquín Romá.
1990: MD, University of Valencia, Spain
Research interests:
Our laboratory employs a multipronged approach to address one basic question: How can a discrete and defined degree of developmental potency be imposed onto a somatic cell so that it regains the ability to regenerate a functional tissue or structure? For this purpose, we use in vivo approaches in animal models (zebrafish heart regeneration), as well as cell-based paradigms built around human pluripotent stem cells.
2017-present Director, Program for Translation of Regenerative Medicine in Catalonia (P-CMRC).
2014-2019: Director, Center of Regenerative Medicine in Barcelona, Barcelona, Spain.
2010-2015: Group Leader, Institute for Bioengineering of Catalonia, Barcelona Science Park, Barcelona, Spain.
2008-present: Group Leader, Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN).
2006-2009: Scientific Coordinator, Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain.
2006-present: ICREA Research Professor.
2004-2006: Senior Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
2000-2004: Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
1999-2000: Senior Research Associate. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1996: Assistant Professor. Department of Physiology, University of Valencia, Spain.
1995-1999: Postdoctoral Research Fellow. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1994-1995: Special Project Associate. Peripheral Nerve Center, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Supervisor: Phillip A. Low.
1991-1995: Graduate student. Department of Physiology, University of Valencia, Spain. Supervisor: Joaquín Romá.
1990: MD, University of Valencia, Spain
Research interests:
Our laboratory employs a multipronged approach to address one basic question: How can a discrete and defined degree of developmental potency be imposed onto a somatic cell so that it regains the ability to regenerate a functional tissue or structure? For this purpose, we use in vivo approaches in animal models (zebrafish heart regeneration), as well as cell-based paradigms built around human pluripotent stem cells.
Non-Zebrafish Publications
- Ferrer-Lorente R, …, Raya A. (2021) Cationic carbosilane dendrimers prevent abnormal alpha-synuclein accumulation in Parkinson’s disease patient-specific dopamine neurons. Biomacromolecules, 22:4582-91.
- Carola G, …, Raya A*, Consiglio A*. (2021) Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration. npj Parkinsons Dis, 7:55.
- Valls-Margarit M, …, Raya A. (2019) Engineered macroscale cardiac constructs elicit human myocardial tissue-like functionality. Stem Cell Rep, 13:207-20.
- Carrió M, …, Raya A*, Serra E* (2019) Reprogramming captures the genetic and tumorigenic properties of Neurofibromatosis Type 1 plexiform neurofibromas. Stem Cell Rep, 12:411-26.
- di Domenico A, …, Raya A*, Consiglio A* (2019) Patient-specific iPSC-derived astrocytes contribute to non-cell autonomous neurodegeneration in Parkinson’s disease. Stem Cell Rep, 12:213-29.
- Notari M, …, Raya A. (2018) The local microenvironment limits the regenerative potential of the mouse neonatal heart. Sci Adv, 4:eaao5553.
- Ojosnegros S, …, Raya A*, Fraser SE*. (2017) Eph-ephrin signaling modulated by polymerization and condensation of receptors. Proc Natl Acad Sci USA, 114(50):13188-93.
- Pulecio J, …, Raya A. (2017) CRISPR/Cas9-based engineering of the epigenome. Cell Stem Cell, 21:431-47.
- Pulecio J, …, Raya A. (2016) Direct conversion of fibroblasts to megakaryocyte progenitors. Cell Rep 17(3):671-683.
- Canals I, …, Raya A. (2015) Activity and High-Order Effective Connectivity Alterations in Sanfilippo C Patient-Specific Neuronal Networks. Stem Cell Rep, 5: 546-57.
- Sanchez-Danés A, …, Raya A. (2012) Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease. EMBO Mol Med, 4:380-395.
- Raya A, …, Izpisúa-Belmonte JC. (2010) A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. Nat Protoc, 5:647-60.
- Raya A, , Belmonte, JC. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature, 460:53-9.
- Raya A, Izpisua Belmonte JC. (2006) Left-right in the vertebrate embryo: from early information to higher-level integration. Nat Rev Genet, 7:283-93.
- Raya A, …, Izpisúa Belmonte JC. (2004) Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. Nature, 427:121-8.
- Raya A, …, Izpisúa Belmonte JC. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev, 17:1213-8.
- Raya A, …, Saus J. (2000) Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternative spliced variant implicated in autoimmune pathogenesis. J Biol Chem, 275:40392-9.
- Raya A, …, Saus J. (1999) Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen. J Biol Chem, 274:12642-9.
- Raya A, …, Romero FJ. (1995) Phenytoin-induced glutathione depletion in rat peripheral nerve. Free Radic Biol Med, 19:665-7.
- Raya A, …, Romá J. (1994) Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats. Neurotoxicol Teratol, 16:11-5.
- Raya A, …, Romero FJ. (1993) Alterations in the antioxidant defense of peripheral nervous tissue following acute ethanol administration. Biochem Soc Trans, 21:92S.
- Raya A, …, Romá J. (1992) Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C. Toxicology, 75:249-56.