ZFIN Person: Caparon, Michael

ZFIN ID: ZDB-PERS-020627-1

ZFIN ID: ZDB-PERS-020627-1

Caparon, Michael

Email:	caparon@borcim.wustl.edu
URL:	http://www.microbiology.wustl.edu/dept/fac/caparon.html
Affiliation:
Address:	Department of Molecular Microbiology Center for Infectious Disease Research Campus Box 8230 Washington University School of Medicine 660 South Euclid Avenue St. Louis, MO 63110-1093 USA
Country:
Phone:	(314) 362-1485
Fax:	(314) 362-3203
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My lab is interested in host-pathogen interaction in bacterial infectious disease with a particular interest in the pathogenesis of infections caused by gram positive bacteria. We have focused on the mechansims that Streptococcus pyogenes (group A streptococcus) uses to modulate signaling behaviour of host cells during the early stagesof infection, and how S. pyogenes modulates expression of its genome to adapt to different host compartments encountered during the infectious process.

PUBLICATIONS

Lin, A., Loughman, J.A., Zinselmeyer, B.H., Miller, M.J., and Caparon, M.G. (2009) Streptolysin S Inhibits Neutrophil Recruitment During the Early Stages of Streptococcus pyogenes Infection. Infection and Immunity. 77(11):5190-5201

Rosch, J.W., Vega, L.A., Beyer, J., Lin, A., and Caparon, M.G. (2008) The Signal Recognition Particle Pathway is Required for Virulence in Streptococcus pyogenes. Infection and Immunity. 76(6):2612-2619

Cho, K.H., and Caparon, M.G. (2005) Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Molecular Microbiology. 57(6):1545-1556

Neely, M.N., Pfeifer, J.D., and Caparon, M. (2002) Streptococcus-zebrafish model of bacterial pathogenesis. Infection and Immunity. 70(7):3904-3914

NON-ZEBRAFISH PUBLICATIONS