ZFIN Person: Posner, Mason

ZFIN ID: ZDB-PERS-020605-1

ZFIN ID: ZDB-PERS-020605-1

Posner, Mason

Email:	mposner@ashland.edu
URL:	http://masonposner.com
Affiliation:	Mason Posner Lab
Address:	Department of Biology/Toxicology Ashland University 401 College Avenue Ashland, OH 44805 USA
Country:
Phone:	(419) 289-5691
Fax:	(419) 289-5283
ORCID ID:	0000-0003-2817-3395

BIOGRAPHY AND RESEARCH INTERESTS

We are interested in the role that crystallin proteins play in the development of the eye lens and maintenance of transparency. Our current projects involve using the cloche mutant to test the ability of overexpressed proteins to prevent lens cataract, analyzing the function of lens crystallin promoters, and producing targeted gene knockouts of several lens crystallins. We also use a comparative approach to investigate the evolution and thermal adaptation of alpha A-crystallin and the evolution of tissue specific expression.

PUBLICATIONS

Posner, M., Murray, K.L., Andrew, B., Brdicka, S., Roberts, A., Franklin, K., Hussen, A., Kaye, T., Kepp, E., McDonald, M.S., Snodgrass, T., Zientek, K., David, L.L. (2022) Impact of α-crystallin protein loss on zebrafish lens development. Experimental Eye Research. 227:109358

Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535

Posner, M., McDonald, M.S., Murray, K.L., Kiss, A.J. (2019) Why does the zebrafish cloche mutant develop lens cataract?. PLoS One. 14:e0211399

Posner, M., Murray, K.L., McDonald, M.S., Eighinger, H., Andrew, B., Drossman, A., Haley, Z., Nussbaum, J., David, L.L., Lampi, K.J. (2017) The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function.. PeerJ. 5:e4093

Posner, M., Skiba, J., Brown, M., Liang, J.O., Nussbaum, J., and Prior, H. (2013) Loss of the small heat shock protein alphaA-crystallin does not lead to detectable defects in early zebrafish lens development. Experimental Eye Research. 116:227-33

Wages, P., Horwitz, J., Ding, L., Corbin, R.W., and Posner, M. (2013) Changes in zebrafish (Danio rerio) lens crystallin content during development. Molecular Vision. 19:408-417

Posner, M., Kiss, A.J., Skiba, J., Drossman, A., Dolinska, M.B., Hejtmancik, J.F., and Sergeev, Y.V. (2012) Functional Validation of Hydrophobic Adaptation to Physiological Temperature in the Small Heat Shock Protein alphaA-crystallin. PLoS One. 7(3):e34438

Posner, M., Hawke, M., Lacava, C., Prince, C.J., Bellanco, N.R., and Corbin, R.W. (2008) A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression. Molecular Vision. 14:806-814

Smith, A.A., Wyatt, K., Vacha, J., Vihtelic, T.S., Samuel Zigler, J. Jr, Wistow, G.J., and Posner, M. (2006) Gene duplication and separation of functions in alphaB-crystallin from zebrafish (Danio rerio). The FEBS journal. 273(3):481-490

Dahlman, J.M., Margot, K.L., Ding, L., Horwitz, J., and Posner, M. (2005) Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs. Molecular Vision. 11:88-96

Runkle, S., Hill, J., Kantorow, M., Horwitz, J., and Posner, M. (2002) Sequence and spatial expression of zebrafish (Danio rerio) alphaA-crystallin. Molecular Vision. 8:45-50

Posner, M., Kantorow, M., and Horwitz, J. (1999) Cloning, sequencing and differential expression of alphaB-crystallin in the zebrafish, Danio rerio. BBA Gene Structure and Expression. 1447(2-3):271-277

NON-ZEBRAFISH PUBLICATIONS