ZFIN Person: Knight, Robert

ZFIN ID: ZDB-PERS-020425-5

ZFIN ID: ZDB-PERS-020425-5

Knight, Robert

Email:	robert.knight@kcl.ac.uk
URL:	https://www.kcl.ac.uk/research/knight-group
Affiliation:
Address:	Craniofacial Development and Stem Cell Biology King's College London London, United Kingdom
Country:
Phone:	+44 20 7188 1798
Fax:	+44 20 7188 1674
ORCID ID:	0000-0001-9920-836X

BIOGRAPHY AND RESEARCH INTERESTS

The focus of the group is to understand the cellular and molecular basis for
musculoskeletal development and regeneration. Current projects include (1) investigating the regulatory basis for head muscle patterning (2) analysing regulators of muscle progenitor cells during regeneration (3)determining the role of the innate immune system during muscle injury and repair. There is also a long standing interest in understanding how proprioceptive neurons make connections to the jaw muscles during development.

PUBLICATIONS

Brondolin, M., Herzog, D., Sultan, S., Warburton, F., Vigilante, A., Knight, R.D. (2023) Migration and differentiation of muscle stem cells are coupled by RhoA signalling during regeneration. Open Biology. 13:230037230037

Baldera, D., Baxendale, S., van Hateren, N.J., Marzo, M., Glendenning, E., Geng, F.S., Yokoya, K., Knight, R.D., Whitfield, T.T. (2023) Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear. Journal of anatomy. 243(1):78-89

Pipalia, T.G., Sultan, S.H.A., Koth, J., Knight, R.D., Hughes, S.M. (2023) Skeletal Muscle Regeneration in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2640:227248227-248

Sultan, S.H.A., Dyer, C., Knight, R.D. (2021) Notch Signaling Regulates Muscle Stem Cell Homeostasis and Regeneration in a Teleost Fish. Frontiers in cell and developmental biology. 9:726281

Lam, S., Hartmann, N., Benfeitas, R., Zhang, C., Arif, M., Turkez, H., Uhlén, M., Englert, C., Knight, R., Mardinoglu, A. (2021) Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. Biomedicines. 9(10):

Mitchell, C., Caroff, L., Solis-Lemus, J.A., Reyes-Aldasoro, C.C., Vigilante, A., Warburton, F., de Chaumont, F., Dufour, A., Dallongeville, S., Olivo-Marin, J.C., Knight, R. (2020) Cell Tracking Profiler: a user-driven analysis framework for evaluating 4D live cell imaging data. Journal of Cell Science. 133(22):

Lleras-Forero, L., Newham, E., Teufel, S., Kawakami, K., Hartmann, C., Hammond, C.L., Knight, R.D., Schulte-Merker, S. (2020) Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis. Aging. 12(18):18603-18621

Roy, S.D., Williams, V.C., Pipalia, T.G., Li, K., Hammond, C.L., Knappe, S., Knight, R.D., Hughes, S.M. (2017) Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration. Developmental Biology. 431(2):321-335

Schall, K.A., Holoyda, K.A., Isani, M., Schlieve, C., Salisbury, T., Khuu, T., Debelius, J.W., Moats, R.A., Pollack, H.A., Lien, C.L., Fowler, K., Hou, X., Knight, R., Grikscheit, T.C. (2017) Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation. Surgery. 161(4):1016-1027

Mitchell, C.A., Poland, S.P., Seyforth, J., Nedbal, J., Gelot, T., Huq, T., Holst, G., Knight, R.D., Ameer-Beg, S.M. (2017) Functional in vivo imaging using fluorescence lifetime light-sheet microscopy. Optics letters. 42:1269-1272

Dyer, C., Blanc, E., Stanley, R.J., Knight, R.D. (2015) Dissecting the role of Wnt signaling and its interactions with FGF signaling during midbrain neurogenesis. Neurogenesis (Austin, Tex.). 2:e1057313

Knappe, S., Zammit, P.S., Knight, R.D. (2015) A population of Pax7-expressing muscle progenitor cells show differential responses to muscle injury dependent on developmental stage and injury extent. Frontiers in aging neuroscience. 7:161

Dyer, C., Linker, C., Graham, A., Knight, R. (2014) Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(11):1429-39

Seedorf, H., Griffin, N.W., Ridaura, V.K., Reyes, A., Cheng, J., Rey, F.E., Smith, M.I., Simon, G.M., Scheffrahn, R.H., Woebken, D., Spormann, A.M., Van Treuren, W., Ursell, L.K., Pirrung, M., Robbins-Pianka, A., Cantarel, B.L., Lombard, V., Henrissat, B., Knight, R., Gordon, J.I. (2014) Bacteria from Diverse Habitats Colonize and Compete in the Mouse Gut. Cell. 159(2):253-66

Poland, S.P., Krstajic, N., Knight, R.D., Henderson, R.K., Ameer-Beg, S.M. (2014) Development of a doubly weighted Gerchberg-Saxton algorithm for use in multibeam imaging applications. Optics letters. 39:2431-2434

Dyer, C., Blanc, E., Hanisch, A., Roehl, H., Otto, G.W., Yu, T., Basson, M.A., and Knight, R. (2014) A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. Development (Cambridge, England). 141(1):63-72

Ericsson, R., Knight, R., and Johanson, Z. (2013) Evolution and development of the vertebrate neck. Journal of anatomy. 222(1):67-78

Knight, R.D., Mebus, K., d'Angelo, A., Yokoya, K., Heanue, T., and Roehl, H. (2011) Ret signalling integrates a craniofacial muscle module during development. Development (Cambridge, England). 138(10):2015-2024

Knight, R.D., Mebus, K., and Roehl, H.H. (2008) Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 310(4):355-369

Elworthy, S., Hargrave, M., Knight, R., Mebus, K., and Ingham, P.W. (2008) Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity. Development (Cambridge, England). 135(12):2115-2126

Hoffman, T.L., Javier, A.L., Campeau, S.A., Knight, R.D., and Schilling, T.F. (2007) Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):679-691

Knight, R.D., and Schilling, T.F. (2006) Cranial neural crest and development of the head skeleton. Advances in experimental medicine and biology. 589:120-133

Knight, R.D., Javidan, Y., Zhang, T., Nelson, S., and Schilling, T.F. (2005) AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Development (Cambridge, England). 132(13):3127-3138

Knight, R.D., Javidan, Y., Nelson, S., Zhang, T., and Schilling, T. (2004) Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Developmental Dynamics : an official publication of the American Association of Anatomists. 229(1):87-98

Knight, R.D., Nair, S., Nelson, S.S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.J., and Schilling, T.F. (2003) lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development (Cambridge, England). 130(23):5755-5768

NON-ZEBRAFISH PUBLICATIONS
Haroon M, Klein-Nulend J, Bakker A. D., Jin J, Seddiqi H, Offringa C, de Wit G. M. J., Le Grand F, Giordani L, Liu K. J., Knight R. D., Jaspers R. T. Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche. Biophys J. 2021 Jul 6;120(13):2665-2678.
doi: 10.1016/j.bpj.2021.05.021.

Moyle, L. M., Blanc, E., Jaka, O., Prueller, J., Banerji, C. R. S., Tedesco, F.S., Harridge, S. D. R., Knight, R. D., Zammit, P. S. 'Ret function in muscle stem cell function points to tyrosine kinase inhibitor therapy for fascioscapulohumeral muscle dystrophy'. eLife (2016) 5:1-35 (e11405).