ZFIN Person: Scott, Ian

ZFIN ID: ZDB-PERS-020424-4

Scott, Ian

Email:	ian.scott@sickkids.ca
URL:	https://lab.research.sickkids.ca/scott/
Affiliation:	Scott Laboratory
Address:	The Hospital for Sick Children The Peter Gilgan Centre for Research and Learning 686 Bay Street Rm 15.9709 Toronto, ON M5G 0A4 Canada
Country:	Canada
Phone:	(416) 813-7654 x301572
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Espinosa, K.G., Geissah, S., Groom, L., Volpatti, J., Scott, I.C., Dirksen, R.T., Zhao, M., Dowling, J.J. (2022) Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy. Disease models & mechanisms. 15(5):

Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834

van Eif, V.W.W., Protze, S.I., Bosada, F.M., Yuan, X., Sinha, T., van Duijvenboden, K., Ernault, A.C., Mohan, R.A., Wakker, V., de Gier-de Vries, C., Hooijkaas, I.B., Wilson, M.D., Verkerk, A.O., Bakkers, J., Boukens, B.J., Black, B.L., Scott, I.C., Christoffels, V.M. (2020) Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer. Circulation research. 127:1522-1535

Lee, S.H., Hadipour-Lakmehsari, S., Murthy, H.R., Gibb, N., Miyake, T., Teng, A.C.T., Cosme, J., Yu, J.C., Moon, M., Lim, S., Wong, V., Liu, P., Billia, F., Fernandez-Gonzalez, R., Stagljar, I., Sharma, P., Kislinger, T., Scott, I.C., Gramolini, A.O. (2020) REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Nature communications. 11:965

Yuan, X., Song, M., Devine, P., Bruneau, B.G., Scott, I.C., Wilson, M.D. (2018) Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. Nature communications. 9:4977

Gibb, N., Lazic, S., Yuan, X., Deshwar, A.R., Leslie, M., Wilson, M.D., Scott, I.C. (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development (Cambridge, England). 145(22):

Zhang, L., Yang, Y., Li, B., Scott, I.C., Lou, X. (2018) The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development (Cambridge, England). 145(8)

Ma, D., Tu, C., Sheng, Q., Yang, Y., Kan, Z., Guo, Y., Shyr, Y., Scott, I.C., Lou, X. (2018) Dynamics of zebrafish heart regeneration using an HPLC-ESI-MS/MS approach. Journal of Proteome Research. 17(3):1300-1308

Razaghi, B., Steele, S.L., Prykhozhij, S.V., Stoyek, M.R., Hill, J.A., Cooper, M.D., McDonald, L., Lin, W., Daugaard, M., Crapoulet, N., Chacko, S., Lewis, S., Scott, I.C., Sorensen, P.H.B., Berman, J.N. (2017) hace1 influences zebrafish cardiac development via ROS-dependent mechanisms. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(2):289-303

Kenney, J.W., Scott, I.C., Josselyn, S.A., Frankland, P.W. (2017) Contextual fear conditioning in zebrafish. Learning & memory (Cold Spring Harbor, N.Y.). 24:516-523

Hou, N., Yang, Y., Scott, I.C., Lou, X. (2017) The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis. Developmental Biology. 421(1):8-15

Deshwar, A.R., Onderisin, J.C., Aleksandrova, A., Yuan, X., Burrows, J.T., Scott, I.C. (2016) Mespaa can potently induce cardiac fates in zebrafish. Developmental Biology. 418(1):17-27

Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63

Deshwar, A.R., Chng, S.C., Ho, L., Reversade, B., Scott, I.C. (2016) The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development. eLIFE. 5

Lou, X., Burrows, J.T., Scott, I.C. (2015) Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. BMC Developmental Biology. 15:41

Sharma, P., Abbasi, C., Lazic, S., Teng, A.C., Wang, D., Dubois, N., Ignatchenko, V., Wong, V., Liu, J., Araki, T., Tiburcy, M., Ackerley, C., Zimmermann, W.H., Hamilton, R., Sun, Y., Liu, P.P., Keller, G., Stagljar, I., Scott, I.C., Kislinger, T., Gramolini, A.O. (2015) Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nature communications. 6:8391

Burrows, J.T., Pearson, B.J., Scott, I.C. (2015) An In Vivo Requirement for the Mediator Subunit Med14 in the Maintenance of Stem Cell Populations. Stem Cell Reports. 4(4):670-84

Liu, Y.C., Couzens, A.L., Deshwar, A.R., B McBroom-Cerajewski, L.D., Zhang, X., Puviindran, V., Scott, I.C., Gingras, A.C., Hui, C.C., Angers, S. (2014) The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Science signaling. 7:ra117

Nesan, D., Kamkar, M., Burrows, J., Scott, I.C., Marsden, M., Vijayan, M.M. (2012) Glucocorticoid Receptor Signaling Is Essential for Mesoderm Formation and Muscle Development in Zebrafish. Endocrinology. 153(3):1288-1300

Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C. (2012) Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Developmental Biology. 362(2):121-131

Lou, X., Deshwar, A.R., Crump, J.G., and Scott, I.C. (2011) Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development (Cambridge, England). 138(15):3113-23

Lazic, S., and Scott, I.C. (2011) Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish. Developmental Biology. 354(1):123-133

Delgado-Olguin, P., Brand-Arzamendi, K., Scott, I.C., Jungblut, B., Stainier, D.Y., Bruneau, B.G., and Recillas-Targa, F. (2011) CTCF Promotes Muscle Differentiation by Modulating the Activity of Myogenic Regulatory Factors. The Journal of biological chemistry. 286(14):12483-94

Chi, N.C., Shaw, R.M., Jungblut, B., Huisken, J., Ferrer, T., Arnaout, R., Scott, I., Beis, D., Xiao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M., and Stainier, D.Y. (2008) Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System. PLoS Biology. 6(5):e109

Davis, J.L., Long, X., Georger, M.A., Scott, I.C., Rich, A., and Miano, J.M. (2008) Expression and comparative genomics of two serum response factor genes in zebrafish. The International journal of developmental biology. 52(4):389-396

Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42

Scott, I.C., Masri, B., D'Amico, L.A., Jin, S.W., Jungblut, B., Wehman, A.M., Baier, H., Audigier, Y., and Stainier, D.Y. (2007) The G protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Developmental Cell. 12(3):403-413

D'Amico, L., Scott, I.C., Jungblut, B., and Stainier, D.Y. (2007) A Mutation in Zebrafish hmgcr1b Reveals a Role for Isoprenoids in Vertebrate Heart-Tube Formation. Current biology : CB. 17(3):252-259

Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204

Scott, I.C. and Stainier, D.Y. (2002) Fishing out a new heart. Science (New York, N.Y.). 298(5601):2141-2142

NON-ZEBRAFISH PUBLICATIONS