ZFIN ID: ZDB-PERS-020116-10
Deflorian, Gianluca
Email: gianluca.deflorian@ifom-ieo-campus.it
URL:
Affiliation: Zebrafish Unit - Cogentech Srl
Address: IFOM, Istituto FIRC di Oncologia Molecolare Via Adamello 16 Milan, I-20139 Italy
Country:
Phone: 39-49-827-6229
Fax: 39-49-827-6300
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
de Latouliere, L., Manni, I., Ferrari, L., Pisati, F., Totaro, M.G., Gurtner, A., Marra, E., Pacello, L., Pozzoli, O., Aurisicchio, L., Capogrossi, M.C., Deflorian, G., Piaggio, G. (2021) MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo. Scientific Reports. 11:671
Spreafico, M., Gruszka, A.M., Valli, D., Mazzola, M., Deflorian, G., Quintè, A., Totaro, M.G., Battaglia, C., Alcalay, M., Marozzi, A., Pistocchi, A. (2020) HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. 8:844
Cafora, M., Deflorian, G., Forti, F., Ferrari, L., Binelli, G., Briani, F., Ghisotti, D., Pistocchi, A. (2019) Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model. Scientific Reports. 9:1527
Mastrodonato, V., Beznoussenko, G., Mironov, A., Ferrari, L., Deflorian, G., Vaccari, T. (2019) A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Scientific Reports. 9:1211
Mazzola, M., Deflorian, G., Pezzotta, A., Ferrari, L., Fazio, G., Bresciani, E., Saitta, C., Ferrari, L., Fumagalli, M., Parma, M., Marasca, F., Bodega, B., Riva, P., Cotelli, F., Biondi, A., Marozzi, A., Cazzaniga, G., Pistocchi, A. (2019) NIPBL: a new player in myeloid cells differentiation. Haematologica. 104(7):1332-1341
Carra, S., Sangiorgio, L., Pelucchi, P., Cermenati, S., Mezzelani, A., Martino, V., Palizban, M., Albertini, A., Götte, M., Kehler, J., Deflorian, G., Beltrame, M., Giordano, A., Reinbold, R., Cotelli, F., Bellipanni, G., Zucchi, I. (2018) Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels. Journal of Cellular Physiology. 233(2):1455-1467
Barbieri, E., Deflorian, G., Pezzimenti, F., Valli, D., Saia, M., Meani, N., Gruszka, A.M., Alcalay, M. (2016) Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development. Oncotarget. 7(34):55302-55312
Loponte, S., Segré, C.V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M.A., Visintin, R., Seiser, C., Chiocca, S. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports. 6:30213
Marchesi, S., Montani, F., Deflorian, G., D'Antuono, R., Cuomo, A., Bologna, S., Mazzoccoli, C., Bonaldi, T., Di Fiore, P.P., Nicassio, F. (2014) DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis. Developmental Cell. 31:420-433
Kobia, F., Duchi, S., Deflorian, G., and Vaccari, T. (2014) Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. Molecular Oncology. 8(2):207-20
Guarani, V., Deflorian, G., Franco, C.A., Krüger, M., Phng, L.K., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M.H., Zimmermann, B., Brandes, R.P., Mione, M., Westphal, C.H., Braun, T., Zeiher, A.M., Gerhardt, H., Dimmeler, S., and Potente, M. (2011) Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature. 473(7346):234-238
Bernardi, E., Deflorian, G., Pezzinenti, F., Diaz, V.M., Mione, M., and Blasi, F. (2010) Characterization of the Regulatory Region of the Zebrafish Prep1.1 Gene: Analogies to the Promoter of the Human PREP1. PLoS One. 5(12):e15047
Vaccari, E., Deflorian, G., Bernardi, E., Pauls, S., Tiso, N., Bortolussi, M., and Argenton, F. (2010) prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Developmental Biology. 343(1-2):94-103
Deflorian, G., Cinquanta, M., Beretta, C., Venuto, A., Santoriello, C., Baldessari, D., Pezzimenti, F., Aliprandi, M., Mione, M., and de Marco, A. (2009) Monoclonal antibodies isolated by large-scale screening are suitable for labeling adult zebrafish (Danio rerio) tissues and cell structures. Journal of immunological methods. 346(1-2):9-17
Meani, N., Pezzimenti, F., Deflorian, G., Mione, M., and Alcalay, M. (2009) The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development. PLoS One. 4(1):e4273
Santoriello, C., Deflorian, G., Pezzimenti, F., Kawakami, K., Lanfrancone, L., d'Adda di Fagagna, F., and Mione, M. (2009) Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells. Disease models & mechanisms. 2(1-2):56-67
Mione, M., Baldessari, D., Deflorian, G., Nappo, G., and Santoriello, C. (2008) How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish. Developmental neuroscience. 30(1-3):65-81
Filippi, A., Tiso, N., Deflorian, G., Zecchin, E., Bortolussi, M., and Argenton, F. (2005) The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 102(12):4377-4382
Deflorian, G., Tiso, N., Ferretti, E., Meyer, D., Blasi, F., Bortolussi, M., and Argenton, F. (2004) Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development (Cambridge, England). 131(3):613-627
Argenton, F., Giudici, S., Deflorian, G., Cimbro, S., Cotelli, F., and Beltrame, M. (2004) Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a transcriptional repressor in early development. Mechanisms of Development. 121(2):131-142
Devos, N., Deflorian, G., Biemar, F., Bortolussi, M., Martial, J.A., Peers, B., and Argenton, F. (2002) Differential expression of two somatostatin genes during zebrafish embryonic development. Mechanisms of Development. 115(1-2):133-137

NON-ZEBRAFISH PUBLICATIONS