ZFIN Person: Dickmeis, Thomas

ZFIN ID: ZDB-PERS-010827-8

ZFIN ID: ZDB-PERS-010827-8

Dickmeis, Thomas

Email:	thomas.dickmeis@kit.edu
URL:	http://www.itg.kit.edu/dickmeis.php
Affiliation:	Dickmeis Lab
Address:	Institute of Toxicology and Genetics (ITG) Karlsruhe Institute of Technology (KIT) Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen
Country:	Germany
Phone:	+49 -721-6082-8485
Fax:	+49-721-6082-3354
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Research interest: Zebrafish endocrinology and metabolism

PhD in the laboratory of Uwe Strähle, Strasbourg, on identification of target genes of the Nodal signalling pathway and analysis of differential gene expression in the midline of the zebrafish embryo. Postdoc on regulation and function of peripheral circadian clocks in the zebrafish in the laboratory of Nicholas Foulkes, Tübingen. Current research interest: endocrine and metabolic timing of cell proliferation.

PUBLICATIONS

Breus, O., Dickmeis, T. (2020) Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration. Biological chemistry. 402(3):363-378

Weger, M., Weger, B.D., Schink, A., Takamiya, M., Stegmaier, J., Gobet, C., Parisi, A., Kobitski, A.Y., Mertes, J., Krone, N., Strähle, U., Nienhaus, G.U., Mikut, R., Gachon, F., Gut, P., Dickmeis, T. (2020) MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLIFE. 9:

Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774

Adhikari, S.S., Zhao, L., Dickmeis, T., Korvink, J.G., Badilita, V. (2019) Inductively coupled magic angle spinning microresonators benchmarked for high-resolution single embryo metabolomic profiling. The Analyst. 144(24):7192-7199

Neukum, A., Bartschat, A., Breitwieser, H., Strähle, U., Dickmeis, T., Pylatiuk, C. (2019) Automated Classification of Fertilized Zebrafish Embryos. Zebrafish. 16(3):326-328

Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15

Leidner, A., Bauer, J., Ebrahimi Khonachah, M., Takamiya, M., Strähle, U., Dickmeis, T., Rabe, K.S., Niemeyer, C.M. (2019) Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles. Biomaterials. 190-191:76-85

Weger, M., Weger, B.D., Görling, B., Poschet, G., Yildiz, M., Hell, R., Luy, B., Akcay, T., Güran, T., Dickmeis, T., Müller, F., Krone, N. (2018) Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine. 36:376-389

Breitwieser, H., Dickmeis, T., Vogt, M., Ferg, M., Pylatiuk, C. (2017) Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos. SLAS technology. 23(2):128-133

Tsachaki, M., Meyer, A., Weger, B., Kratschmar, D.V., Tokarz, J., Adamski, J., Belting, H.G., Affolter, M., Dickmeis, T., Odermatt, A. (2017) Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. The Journal of endocrinology. 232(2):323-335

Geisler, R., Köhler, A., Dickmeis, T., Strähle, U. (2017) Archiving of zebrafish lines can reduce animal experiments in biomedical research. EMBO reports. 18(1):1-2

Weger, B.D., Weger, M., Görling, B., Schink, A., Gobet, C., Keime, C., Poschet, G., Jost, B., Krone, N., Hell, R., Gachon, F., Luy, B., Dickmeis, T. (2016) Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids. PLoS Genetics. 12:e1006512

Schutera, M., Dickmeis, T., Mione, M., Peravali, R., Marcato, D., Reischl, M., Mikut, R., Pylatiuk, C. (2016) Automated Phenotype Pattern Recognition of Zebrafish for High-throughput Screening. Bioengineered. 7(4):261-5

Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016) Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports. 6:23768

Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645

Ferg, M., Armant, O., Yang, L., Dickmeis, T., Rastegar, S., and Strähle, U. (2014) Gene transcription in the zebrafish embryo: regulators and networks. Briefings in Functional Genomics. 13(2):131-43

Tixier, V., Bataillé, L., Etard, C., Jagla, T., Weger, M., Daponte, J.P., Strähle, U., Dickmeis, T., and Jagla, K. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America. 110(47):18982-7

Weger, B.D., Weger, M., Jung, N., Lederer, C., Bräse, S., and Dickmeis, T. (2013) A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. Journal of visualized experiments : JoVE. (79)

Mikut, R., Dickmeis, T., Driever, W., Geurts, P., Hamprecht, F.A., Kausler, B.X., Ledesma-Carbayo, M.J., Marée, R., Mikula, K., Pantazis, P., Ronneberger, O., Santos, A., Stotzka, R., Strähle, U., and Peyriéras, N. (2013) Automated Processing of Zebrafish Imaging Data: A Survey. Zebrafish. 10(3):401-21

Weger, M., Weger, B.D., Diotel, N., Rastegar, S., Hirota, T., Kay, S.A., Strähle, U., and Dickmeis, T. (2013) Real-time in vivo monitoring of circadian E-box enhancer activity: A robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology. 380(2):259-73

Weger, B.D., Weger, M., Nusser, M., Brenner-Weiss, G., and Dickmeis, T. (2012) A Chemical Screening System for Glucocorticoid Stress Hormone Signaling in an Intact Vertebrate. ACS Chemical Biology. 7(7):1178-1183

Weger, B.D., Sahinbas, M., Otto, G.W., Mracek, P., Armant, O., Dolle, D., Lahiri, K., Vallone, D., Ettwiller, L., Geisler, R., Foulkes, N.S., and Dickmeis, T. (2011) The light responsive transcriptome of the zebrafish: function and regulation. PLoS One. 6(2):e17080

Rastegar, S., Hess, I., Dickmeis, T., Nicod, J.C., Ertzer, R., Hadzhiev, Y., Thies, W.G., Scherer, G., and Strähle, U. (2008) The words of the regulatory code are arranged in a variable manner in highly conserved enhancers. Developmental Biology. 318(2):366-377

Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS One. 3(1):e1434

Dickmeis, T., Lahiri, K., Nica, G., Vallone, D., Santoriello, C., Neumann, C.J., Hammerschmidt, M., and Foulkes, N.S. (2007) Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms. PLoS Biology. 5(4):e78

Lahiri, K., Vallone, D., Gondi, S.B., Santoriello, C., Dickmeis, T., and Foulkes, N.S. (2005) Temperature Regulates Transcription in the Zebrafish Circadian Clock. PLoS Genetics. 3(11):e351

Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U. (2005) Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. Trends in genetics : TIG. 21(4):207-210

Vallone, D., Lahiri, K., Dickmeis, T., and Foulkes, N.S. (2005) Zebrafish Cell Clocks Feel the Heat and See the Light!. Zebrafish. 2(3):171-187

Dickmeis, T., Plessy, C., Rastegar, S., Aanstad, P., Herwig, R., Chalmel, F., Fischer, N., and Strähle, U. (2004) Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Genome research. 14(2):228-238

Mathieu, J., Griffin, K., Herbomel, P., Dickmeis, T., Strähle, U., Kimelman, D., Rosa, F.M., and Peyriéras, N. (2004) Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Development (Cambridge, England). 131(3):629-641

Dickmeis, T., Rastegar, S., Lam, C.S., Aanstad, P., Clark, M., Fischer, N., Rosa, F., Korzh, V., and Strähle, U. (2002) Expression of the helix-loop-helix gene id3 in the zebrafish embryo. Mechanisms of Development. 113(1):99-109

Aoki T.O., David, N.B., Minchiotti, G., Saint-Etienne, L., Dickmeis, T., Persico, G.M., Strähle, U., Mourrain, P., and Rosa, F.M. (2002) Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation. Development (Cambridge, England). 129(2):275-286

Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U. (2001) Expression of brain subtype creatine kinase in the zebrafish embryo. Mechanisms of Development. 109(2):409-412

Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Korzh, V., and Strähle, U. (2001) Expression of the anti-dorsalizing morphogenetic protein gene in the zebrafish embryo. Development genes and evolution. 211(11):568-572

Dickmeis, T., Aanstad, P., Clark, M., Fischer, N., Herwig, R., Mourrain, P., Blader, P., Rosa, F., Lehrach, H., and Strähle, U. (2001) Identification of nodal signaling targets by array analysis of induced complex probes. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):571-580

Dickmeis, T., Mourrain, P., Saint-Etienne, L., Fischer, N., Aanstad, P., Clark, M., Strähle, U., and Rosa, F. (2001) A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene. Genes & Development. 15(12):1487-1492

NON-ZEBRAFISH PUBLICATIONS
Glucocorticoids and the circadian clock.
Dickmeis T.
J Endocrinol. 2009 Jan;200(1):3-22. Epub 2008 Oct 29.
PMID: 18971218 [PubMed - in process]

The identification and functional characterisation of conserved regulatory elements in developmental genes.
Dickmeis T, Müller F.
Brief Funct Genomic Proteomic. 2005 Feb;3(4):332-50. Review.
PMID: 15814024 [PubMed - indexed for MEDLINE]