Biography and Research Interest

Publications

Non-Zebrafish Publications

Sturr, M. G., Ablooglu, A. J., and Krulwich, T. A. (1997). A Bacillus subtilis locus encoding several gene products affecting transport of cations. Gene 188, 91-94.

Cann, A. D., Bishop, S. M., Ablooglu, A. J., and Kohanski, R. A. (1998). Partial activation of the insulin receptor kinase domain by juxtamembrane autophosphorylation. Biochemistry 37, 11289-11300.

Frankel, M., Bishop, S. M., Ablooglu, A. J., Han, Y. P., and Kohanski, R. A. (1999). Conformational changes in the activation loop of the insulin receptor's kinase domain. Protein Sci. 8, 2158-2165.

Ablooglu, A. J., Till, J. H., Kim, K., Parang, K., Cole, P. A., Hubbard, S. R., and Kohanski, R. A. (2000). Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. J. Biol. Chem. 275, 30394-30398.

Till, J. H., Ablooglu, A. J., Frankel, M., Bishop, S. M., Kohanski, R.A., and Hubbard, S. R. (2001). Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase: Insights into Kinase Mechanism. J. Biol. Chem. 276, 10049-10055.

Ablooglu, A. J., and Kohanski, R. A. (2001). Activation of the Insulin Receptor's Kinase Domain Changes the Rate- Determining Step of Substrate Phosphorylation. Biochemistry 40, 504-513.

Ablooglu, A. J.,* Parang, K.,* Till, J. H.,* Kohanski, R. A., Hubbard, S. R., and Cole, P. A. (2001). Mechanism-based design of a protein kinase inhibitor. Nat. Struct. Biol. 8, 37-41.

Frankel, M. F., Ablooglu, A. J., Leone, J. W., Rusinova, E., Ross, J.B.A., Heinrikson, R. L., and Kohanski, R. A. (2001). Intrasteric Inhibition of ATP Binding is not Required to Prevent Unregulated Autophosphorylation or Signaling By the Insulin Receptor. Mol. Cell. Biol. 21, 4197-4207.

Ablooglu, A. J., Frankel, M., Rusinova, E., Ross, J. B. A., and Kohanski, R. A. (2001). Multiple Activation Loop Conformations and their Regulatory Properties the Insulin Receptor’s Kinase Domain. J. Biol. Chem. 276, 46933-40.

Petrich, B. G., Fogelstrand, R., Partridge, A. W., Yousefi, N., Ablooglu, A. J., Shattil, S. J., and Ginsberg, M. H. (2007). The Anti-Thrombotic Potential of Selective Blockade of Talin-Dependent Integrin ±IIb²3 (Platelet GPIIb-IIIa) Activation. The Journal of Clinical Investigation 117, 2250-2259.

Ablooglu. A.J., Kang J., Petrich B.G., Ginsberg M.H., and Shattil S.J. (2009). Anti-Thrombotic Effects of Targeting ±IIbβ3 Signaling in Platelets. Blood 113, 3585-3592.