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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-001205-4
Liu, Yan
Email: yliu@receptor.mgh.harvard.edu
URL:
Affiliation: Drummond Lab
Address: Renal Unit Massachusetts General Hospital Harvard Medical School 149 13th Street Charlestown, MA 02129 USA
Country:
Phone: 617-724-9693
Fax: (617) 726-5669
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Pu, Y.Z., Liang, L., Fu, A.L., Liu, Y., Sun, L., Li, Q., Wu, D., Sun, M.J., Zhang, Y.G., Zhao, B.Q. (2017) Generation of Alzheimer's Disease Transgenic Zebrafish Expressing Human APP Mutation under Control of Zebrafish appb Promotor. Current Alzheimer research. 14(6):668-679
Liu, Y., Zhang, Y., Tao, S., Guan, Y., Zhang, T., Wang, Z. (2016) Global DNA methylation in gonads of adult zebrafish Danio rerio under bisphenol A exposure. Ecotoxicology and environmental safety. 130:124-132
Ou, C., Zhang, S., Liu, J., Shen, J., Liu, Y., Sun, X., Li, J., Wang, L. (2015) Removal of multi-substituted nitroaromatic pollutants by zero valent iron: a comparison of performance, kinetics, toxicity and mechanisms. Physical chemistry chemical physics : PCCP. 17:22072-8
Kamei, C.N., Liu, Y., Drummond, I.A. (2015) Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury. Journal of visualized experiments : JoVE. (102):e51912
Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., Sosnovik, D.E., Shin, J.T., Haber, D.A., Berman, J.N., Chao, W., Peterson, R.T. (2014) Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science Translational Medicine. 6:266ra170
Xu, M., Liu, D., Dong, Z., Wang, X., Wang, X., Liu, Y., Baas, P.W., Liu, M. (2014) Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton (Hoboken, N.J.). 71(10):555-63
Pathak, N., Austin-Tse, C.A., Liu, Y., Vasilyev, A., Drummond, I.A. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Molecular biology of the cell. 25(12):1836-44
Huang, L.D., Fan, Y.Z., Tian, Y., Yang, Y., Liu, Y., Wang, J., Zhao, W.S., Zhou, W.C., Cheng, X.Y., Cao, P., Lu, X.Y., Yu, Y. (2014) Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations. PLoS One. 9:e97528
Lam, P.Y., Kamei, C.N., Mangos, S., Mudumana, S., Liu, Y., and Drummond, I.A. (2013) odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 242(11):1284-92
Austin-Tse, C., Halbritter, J., Zariwala, M.A., Gilberti, R.M., Gee, H.Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J.R., Patel-King, R.S., Tritschler, D., Bower, R., O'Toole, E., Porath, J.D., Hurd, T.W., Chaki, M., Diaz, K.A., Kohl, S., Lovric, S., Hwang, D.Y., Braun, D.A., Schueler, M., Airik, R., Otto, E.A., Leigh, M.W., Noone, P.G., Carson, J.L., Davis, S.D., Pittman, J.E., Ferkol, T.W., Atkinson, J.J., Olivier, K.N., Sagel, S.D., Dell, S.D., Rosenfeld, M., Milla, C.E., Loges, N.T., Omran, H., Porter, M.E., King, S.M., Knowles, M.R., Drummond, I.A., and Hildebrandt, F. (2013) Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American journal of human genetics. 93(4):672-686
Sanna-Cherchi, S., Sampogna, R.V., Papeta, N., Burgess, K.E., Nees, S.N., Perry, B.J., Choi, M., Bodria, M., Liu, Y., Weng, P.L., Lozanovski, V.J., Verbitsky, M., Lugani, F., Sterken, R., Paragas, N., Caridi, G., Carrea, A., Dagnino, M., Materna-Kiryluk, A., Santamaria, G., Murtas, C., Ristoska-Bojkovska, N., Izzi, C., Kacak, N., Bianco, B., Giberti, S., Gigante, M., Piaggio, G., Gesualdo, L., Vukic, D.K., Vukojevic, K., Saraga-Babic, M., Saraga, M., Gucev, Z., Allegri, L., Latos-Bielenska, A., Casu, D., State, M., Scolari, F., Ravazzolo, R., Kiryluk, K., Al-Awqati, Q., D'Agati, V.D., Drummond, I.A., Tasic, V., Lifton, R.P., Ghiggeri, G.M., and Gharavi, A.G. (2013) Mutations in DSTYK and Dominant Urinary Tract Malformations. New. Engl. J. Med.. 369(7):621-9
Nath, A.K., Roberts, L.D., Liu, Y., Mahon, S.B., Kim, S., Ryu, J.H., Werdich, A., Januzzi, J.L., Boss, G.R., Rockwood, G.A., MacRae, C.A., Brenner, M., Gerszten, R.E., and Peterson, R.T. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(5):1928-1938
Jin, S., Sarkar, K.S., Jin, Y.N., Liu, Y., Kokel, D., Van Ham, T.J., Roberts, L.D., Gerszten, R.E., MacRae, C.A., and Peterson, R.T. (2013) An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action. Journal of Biomolecular Screening. 18(1):108-115
Manning, D.K., Sergeev, M., van Heesbeen, R.G., Wong, M.D., Oh, J.H., Liu, Y., Henkelman, R.M., Drummond, I., Shah, J.V., and Beier, D.R. (2013) Loss of the ciliary kinase nek8 causes left-right asymmetry defects. Journal of the American Society of Nephrology : JASN. 34(1):100-112
Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012) CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics. 44(6):714-719
Cui, J., Zhang, Z., Bai, W., Zhang, L., He, X., Ma, Y., Liu, Y., and Chai, Z. (2012) Effects of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos. Journal of environmental sciences (China). 24(2):209-213
Vasilyev, A., Liu, Y., Hellman, N., Pathak, N., and Drummond, I.A. (2012) Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros. PLoS One. 7(7):e39992
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Zhang, M., Liu, Y., Wang, S.Z., Zhong, W., Liu, B.H., and Tao, H.W. (2011) Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14):5460-5469
Hellman, N.E., Liu, Y., Merkel, E., Austin, C., Le Corre, S., Beier, D.R., Sun, Z., Sharma, N., Yoder, B.K., and Drummond, I.A. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc. Natl. Acad. Sci. USA. 107(43):18499-18504
Mangos, S., Lam, P.Y., Zhao, A., Liu, Y., Mudumana, S., Vasilyev, A., Liu, A., and Drummond, I.A. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Disease models & mechanisms. 3(5-6):354-365
Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9
Mudumana, S.P., Hentschel, D., Liu, Y., Vasilyev, A., and Drummond, I.A. (2008) odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development (Cambridge, England). 135(20):3355-3367
Pathak, N., Obara, T., Mangos, S., Liu, Y., and Drummond, I.A. (2007) The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation. Molecular biology of the cell. 18(11):4353-4364
Liu, Y., Pathak, N., Kramer-Zucker, A., and Drummond, I.A. (2007) Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development (Cambridge, England). 134(6):1111-1122
Mangos, S., Liu, Y., and Drummond, I.A. (2007) Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish. Gene expression patterns : GEP. 7(4):480-484
Smear, M.C., Tao, H.W., Staub, W., Orger, M.B., Gosse, N.J., Liu, Y., Takahashi, K., Poo, M.M., and Baier, H. (2007) Vesicular Glutamate Transport at a Central Synapse Limits the Acuity of Visual Perception in Zebrafish. Neuron. 53(1):65-77
Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., and Drummond, I.A. (2006) Polycystin-2 Immunolocalization and Function in Zebrafish. Journal of the American Society of Nephrology : JASN. 17(10):2706-2718
Sayer, J.A., Otto, E.A., O'toole, J.F., Nurnberg, G., Kennedy, M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett, B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J., Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S., Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R., and Hildebrandt, F. (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nature Genetics. 38(6):674-681
Liu, Y., and Halloran, M.C. (2005) Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(45):10556-10563
Wolman, M.A., Liu, Y., Tawarayama, H., Shoji, W., and Halloran, M.C. (2004) Repulsion and attraction of axons by Semaphorin3D are mediated by different neuropilins in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(39):8428-8435
Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J.Y., and Halloran, M.C. (2004) Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(2):310-318

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