ZFIN Person: Kamermans, Maarten

ZFIN ID: ZDB-PERS-000913-3

ZFIN ID: ZDB-PERS-000913-3

Kamermans, Maarten

Email:	m.kamermans@ioi.knaw.nl
URL:	http://www.nin.knaw.nl/research_groups/kamermans_group/
Affiliation:	Kamermans Lab
Address:	Retinal Signal Processing Group The Netherlands Ophthalmic Research Institute Meibergdreef 47 Amsterdam, 1105 BA Netherlands
Country:
Phone:	31-20-566-5180 or 31-20-566-6101
Fax:	31-20-566-6121
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My current research involves the signal processing in the retina of zebrafish and goldfish. The projects are focussed on the synaptic interaction between retinal neurons and the coding patterns of ganglion cells. One of the goals is to account for the behavior of the retinal network based on the cellular and sub-cellular properties of the retinal neurons. In this respect is the retina a unique preparation because it contains two types of synapses: synapses between spiking neurons and synapses working in a graded mode. The analogies and differences between these types of synapses, both on functional and molecular level are one of my main interests. The research in my group covers in three themes: 1) the mechanism of synaptic transmission of sustained responding neurons, 2) integration of neural signals in the retinal network, and 3) neuroplasicity of the retinal network.
In my group we use intracellular, extracellular and patch-clamp recording techniques in isolated retinae, retinal slices and dissociated cells as well as morphological, molecular, computational and behavioral techniques.

PUBLICATIONS

Montijn, J.S., Seignette, K., Howlett, M.H., Cazemier, J.L., Kamermans, M., Levelt, C.N., Heimel, J.A. (2021) A parameter-free statistical test for neuronal responsiveness. eLIFE. 10:

Greb, H., Klaassen, L.J., Schultz, K., Kamermans, M., Zoidl, G., Weiler, R., Janssen-Bienhold, U. (2018) An alternative splice variant of zebrafish cx52.6 is expressed in retinal horizontal cells. Neuroscience. 388:191-202

Dona, M., Slijkerman, R., Lerner, K., Broekman, S., Wegner, J., Howat, T., Peters, T., Hetterschijt, L., Boon, N., de Vrieze, E., Sorusch, N., Wolfrum, U., Kremer, H., Neuhauss, S., Zang, J., Kamermans, M., Westerfield, M., Phillips, J., van Wijk, E. (2018) Usherin defects lead to early-onset retinal dysfunction in zebrafish. Experimental Eye Research. 173:148-159

Cenedese, V., de Graaff, W., Csikós, T., Poovayya, M., Zoidl, G., Kamermans, M. (2017) Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones. Frontiers in molecular neuroscience. 10:403

Klaassen, L.J., de Graaff, W., Van Asselt, J.B., Klooster, J., Kamermans, M. (2016) Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina. Journal of neurophysiology. 116(6):2799-2814

Lodder, E.M., De Nittis, P., Koopman, C.D., Wiszniewski, W., Moura de Souza, C.F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E.A., Boualla, L., Blom, N.A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Akdemir, Z.H., Fish, R.J., Eldomery, M.K., Ratbi, I., Wilde, A.A., de Boer, T., Simonds, W.F., Neerman-Arbez, M., Sutton, V.R., Kok, F., Lupski, J.R., Reymond, A., Bezzina, C.R., Bakkers, J., Merla, G. (2016) GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability. American journal of human genetics. 99(3):704-10

Vroman, R., Klaassen, L.J., Howlett, M.H., Cenedese, V., Klooster, J., Sjoerdsma, T., Kamermans, M. (2014) Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. PLoS Biology. 12:e1001864

Kurtenbach, S., Prochnow, N., Kurtenbach, S., Klooster, J., Zoidl, C., Dermietzel, R., Kamermans, M., and Zoidl, G. (2013) Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One. 8(10):e77722

Endeman, D., Klaassen, L.J., and Kamermans, M. (2013) Action spectra of zebrafish cone photoreceptors. PLoS One. 8(7):e68540

Klaassen, L., Fahrenfort, I., and Kamermans, M. (2012) Connexin Hemichannel Mediated Ephaptic Inhibition in the Retina. Brain research. 1487:25-38

Sun, Z., Risner, M.L., van Asselt, J.B., Zhang, D.Q., Kamermans, M., and McMahon, D.G. (2012) Physiological and Molecular Characterization of Connexin Hemichannels in Zebrafish Retinal Horizontal Cells. Journal of neurophysiology. 107(10):2624-2632

Peachey, N.S., Ray, T.A., Florijn, R., Rowe, L.B., Sjoerdsma, T., Contreras-Alcantara, S., Baba, K., Tosini, G., Pozdeyev, N., Iuvone, P.M., Bojang, P., Pearring, J.N., Simonsz, H.J., van Genderen, M., Birch, D.G., Traboulsi, E.I, Dorfman, A., Lopez, I., Ren, H., Goldberg, A.F., Nishina, P.M., Lachapelle, P., McCall, M.A., Koenekoop, R.K., Bergen, A.A., Kamermans, M., and Gregg, R.G. (2012) GPR179 Is Required for Depolarizing Bipolar Cell Function and Is Mutated in Autosomal-Recessive Complete Congenital Stationary Night Blindness. American journal of human genetics. 90(2):331-339

Klaassen, L.J., Sun, Z., Steijaert, M.N., Bolte, P., Fahrenfort, I., Sjoerdsma, T., Klooster, J., Claassen, Y., Shields, C.R., Ten Eikelder, H.M., Janssen-Bienhold, U., Zoidl, G., McMahon, D.G., and Kamermans, M. (2011) Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels. PLoS Biology. 9(7):e1001107

Kasher, P.R., Namavar, Y., van Tijn, P., Fluiter, K., Sizarov, A., Kamermans, M., Grierson, A.J., Zivkovic, D., and Baas, F. (2011) Impairment of the tRNA splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of Pontocerebellar Hypoplasia. Human molecular genetics. 20(8):1574-84

Prochnow, N., Hoffmann, S., Vroman, R., Klooster, J., Bunse, S., Kamermans, M., Dermietzel, R., and Zoidl, G. (2009) Pannexin1 in the outer retina of the zebrafish, Danio rerio. Neuroscience. 162(4):1039-1054

Klooster, J., Yazulla, S., and Kamermans, M. (2009) Ultrastructural analysis of the glutamatergic system in the outer plexiform layer of zebrafish retina. Journal of chemical neuroanatomy. 37(4):254-265

Ul-Hussain, M., Zoidl, G., Kloster, J., Kamermans, M., and Dermietzel, R. (2008) IRES-mediated translation of the carboxy-terminal domain of the horizontal cell specific connexin Cx55.5 in vivo and in vitro. BMC Molecular Biology. 9:52

Godinho, L., Williams, P.R., Claassen, Y., Provost, E., Leach, S.D., Kamermans, M., and Wong, R.O. (2007) Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo. Neuron. 56(4):597-603

Shields, C.R., Klooster, J., Claassen, Y., Ul-Hussain, M., Zoidl, G., Dermietzel, R., and Kamermans, M. (2007) Retinal horizontal cell-specific promoter activity and protein expression of zebrafish connexin 52.6 and connexin 55.5. The Journal of comparative neurology. 501(5):765-779

NON-ZEBRAFISH PUBLICATIONS
1. W. Kamphuis, J. Klooster, F. Dijk (2002) Expression of AMPA-type Glutamate receptor subunits (GluR2) in ON-bipolar neurons in the rat retina. J. Comp. Neurol. 455: 172-186.
2. J. Klooster, K. Studholme and S. Yazulla (2001) Localization of the AMPA subunit GluR2 in the outer plexiform layer of goldfish retina. J. Comp. Neurol. 441: 155-167.
3. M. Kamermans, D.A. Kraaij and H. Spekreijse (2001) The dynamics of the signal from horizontal cells to cones in the goldfish retina . J Physiol 534.2: 480-500.
4. M. Kamermans, I. Fahrenfort, K. Schultz, U. Janssen-Bienhold, T. Sjoerdsma and R. Weiler (2001) Hemichannel-mediated inhibition in the outer retina. Science 292: 1178-1180.
5. P. Hardus, W.M. Verduin, M. Kamermans, G. Postma, J.S. Stilma, T.T.J.M. Berendschot and C.W.M. van Veelen (2001) The value of electrophysiological results in patients with epilepsy and vigabatrin associated visual field loss. Acta Ophthal Scan 79:169-174.
6. C.A.V. Vandenbranden, W. Kamphuis, B. Nunes Cardozo and M. Kamermans (2000) Immunocytochemical localization of glutamate receptor subunits in the goldfish retina. J Neurocytol. 29(10):729-742.
7. D.A.Kraaij, H., Spekreijse and M. Kamermans (2000) The open and closed loop characteristics of the cone/horizontal cell synapse in goldfish retina J Neurophysiol 84: 1256-1265.
8. J. Klooster, W. Kamphuis, G.F.J.M. Vrensen (2000) Imunohistochemical localization of substance P and substance P receptor (NK1) in the olivary pretectal nucleus of the rat. Exp. Brain Res. 131: 57-63
9. C.A.V. Vandenbranden, S. Yazulla, K. Studholm, W. Kamphuis and M. Kamermans (2000) Immunolocalization of the glutamate transporter GLT-1 in the goldfish (Carassius auratus) retina. J Comp Neurol 423(3):440-451.
10. D.A. Kraaij, H. Spekreijse and M. Kamermans (2000) The nature of surround induced depolarizing responses in goldfish cones. J Gen Physiol 115:1-14.
11. D.A. Kraaij (2000) Spectral and dynamic properties of cone/horizontal cell interaction in goldfish retina. Ph.D. thesis. University of Amsterdam.
12. Fahrenfort, R. Habets, H. Spekreijse and M. Kamermans (1999) Intrinsic cone adaptation modulates feedback efficiency from horizontal cells to cones. J Gen Physiol 114:511-524.
13. T. Sjoerdsma, M. Kamermans and H. Spekreijse (1999) Modulating wavelength discrimination in goldfish with ethambutol and stimulus intensity. Vision Res 39(17):2955-2962
14. M. Kamermans and H. Spekreijse (1999) The feedback pathway from horizontal cells to cones in the goldfish retina. A mini review with a look ahead. Vision Res 39(15):2449-2468
15. M. Kamermans, D.A. Kraaij and H. Spekreijse (1998) The Cone/Horizontal cell network: A possible site for color constancy. Vis Neurosci 15:787-797
16. D.A. Kraaij, M. Kamermans and H. Spekreijse (1998) Spectral sensitivity of the feedback signal from horizontal cells to cones in the goldfish retina. Vis Neurosci 15:799-808
17. J. Verweij, M. Kamermans, K. Negishi and H. Spekreijse (1998) GABA sensitivity of spectrally classified horizontal cells in goldfish retina. Vis Neurosci 15:77-86
18. J. Bhattacharjee, B. Nunes Cardozo, W. Kamphuis, M. Kamermans and G. F. J. M. Vrensen (1997) Pseudo-immunolabelling with the Avidin-Biotin-Peroxidase Complex (ABC) due to the presence of endogenous biotin in retinal Müller cells of goldfish and salamander. J Neurosci Meth 77:75-82
19. J. Verweij (1996) Synaptic interactions in the outer retina of goldfish. An electrophysiological and pharmacological study. Ph.D. thesis. University of Amsterdam.
20. M. Kamermans and H. Spekreijse (1996) The dynamics of the outer retina. A functional description based on morphology, physiology and neural modelling. Vision Res 36(24):3857-3858
21. J. Verweij, M. Kamermans, E.C. van den Aker and H. Spekreijse (1996) Modulation of horizontal cell receptive fields in the light adapted goldfish retina. Vision Res 36(24):3913-3923
22. J. Verweij, M. Kamermans and H. Spekreijse (1996) Horizontal cells feedback to cones by shifting the cone calcium current activation range. Vision Res 36(24):3943-3953
23. M. Kamermans, J. Haak, J.B.A. Habraken and H. Spekreijse (1996) The size of the horizontal cell receptive fields adapts to the stimulus in the light adapted retina. Vision Res 36(24):4105-4119
24. C.A.V. Vandenbranden, J. Verweij, M. Kamermans, L.J. Müller, J.M. Ruijter, G.F.J.M. Vrensen and H. Spekreijse (1996) Clearance of neurotransmitters from the synaptic cleft of goldfish retina. Vision Res 36(24):3859-3874
25. T. Sjoerdsma, M. Kamermans and H. Spekreijse (1996) Effect of ethambutol and stimulus intensity on wavelength discrimination in goldfish. Vision Res 36(21):3519-3523
26. J.J. Wietsma, M. Kamermans and H. Spekreijse (1995) Horizontal cells function normally in ethambutol-treated goldfish. Vision Res 35(12):1667-1674
27. M. Kamermans and H. Spekreijse (1995) Spectral coding of cone-driven horizontal cells in teleost retina. Prog in Ret and Eye Res 14(1):313-360
28. J.J. Wietsma (1994) Induced color blindness. A behavioral and electrophysiologcal study on pharmacologically induced color vision disturbances in goldfish. Ph.D. thesis. University of Amsterdam. Buijten & Schipperheijn, Amsterdam.
29. M. Kamermans and F.S. Werblin (1992) GABA-Mediated positive autofeedback loop controls horizontal cell kinetics in tiger salamander retina. J Neurosci 12(7):2451-2463
30. M. Kamermans, B.W. van Dijk, H. Spekreijse and F.S. Werblin (1991) A model for the changes in coupling and kinetics of cone driven retinal horizontal cells during light/dark adaptation. In: Proceedings of Analysis and Modelling of Neural Systems. Berkeley, July 25-27, 1990
31. M. Kamermans, B.W. van Dijk and H. Spekreijse (1991) Color opponency in cone driven horizontal cells in carp retina; Aspecific pathways between cones and horizontal cells. J Gen Physiol 87:819-843
32. M. Kamermans, B.W. van Dijk and H. Spekreijse (1990) Interaction between the soma and axon terminal of retinal horizontal cells. Vision Res 30:1011-1016.
33. M. Kamermans (1989) The functional organization of the horizontal cell layers in carp retina. Ph.D. thesis. University of Amsterdam. Rodopi, Amsterdam
34. M. Kamermans, B.W. van Dijk and H. Spekreijse (1989) Lateral feedback from monophasic horizontal cells to cones in carp retina. II: A quantitative model. J Gen Physiol 93: 695-714.
35. M. Kamermans, B.W. van Dijk, H. Spekreijse and R.C.V.J. Zweypfenning (1989) Lateral feedback from monophasic horizontal cells to cones in carp retina. I: Experiments. J Gen Physiol 93: 681-694.
36. M. Kamermans, B.W. van Dijk and H. Spekreijse (1989) Carp responses of color coded ganglion cells evoked by current injection into horizontal cells. Neurobiol. of the inner retina. Nato ASI Series. Ed. R. Weiler and N.N. Osborne. Springer Verlag. Vol. H31:503-512.