ZFIN ID: ZDB-PERS-000330-14
Xu, Xiaolei
Email: xu.xiaolei@mayo.edu
Affiliation: Xu Lab
Address: Department of Biochemistry and Molecular Biology Division of Cardiovascular Diseases Mayo Clinic College of Medicine 200 First Street SW Rochester, MN 55905 USA
Country: United States
Phone: (507) 284-0685
Fax: (507) 284-0762


Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
Koslow, M., Zhu, P., McCabe, C., Xu, X., Lin, X. (2023) Kidney transcriptome and cystic kidney disease genes in zebrafish. Frontiers in Physiology. 14:11840251184025
Moossavi, M., Lu, X., Herrmann, J., Xu, X. (2023) Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play. Frontiers in cardiovascular medicine. 10:10802991080299
Niu, Y., Sun, Y., Liu, Y., Du, K., Xu, X., Ding, Y. (2023) Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy. International Journal of Molecular Sciences. 24(4):
Koslow, M., Mondaca-Ruff, D., Xu, X. (2023) Transcriptome studies of inherited dilated cardiomyopathies. Mammalian genome : official journal of the International Mammalian Genome Society. 34(2):312-322
Sabharwal, A., Wishman, M.D., Cervera, R.L., Serres, M.R., Anderson, J.L., Holmberg, S.R., Kar, B., Treichel, A.J., Ichino, N., Liu, W., Yang, J., Ding, Y., Deng, Y., Lacey, J.M., Laxen, W.J., Loken, P.R., Oglesbee, D., Farber, S.A., Clark, K.J., Xu, X., Ekker, S.C. (2022) Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLIFE. 11:
Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
Sabharwal, A., Campbell, J.M., Schwab, T.L., WareJoncas, Z., Wishman, M.D., Ata, H., Liu, W., Ichino, N., Hunter, D.E., Bergren, J.D., Urban, M.D., Urban, R.M., Holmberg, S.R., Kar, B., Cook, A., Ding, Y., Xu, X., Clark, K.J., Ekker, S.C. (2022) A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes. 13(8):
Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):
Baek, K.I., Chang, S.S., Chang, C.C., Roustaei, M., Ding, Y., Wang, Y., Chen, J., O'Donnell, R., Chen, H., Ashby, J.W., Xu, X., Mack, J.J., Cavallero, S., Roper, M., Hsiai, T.K. (2022) Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network. Frontiers in cardiovascular medicine. 9:841101
Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2022) Corrigendum to 'Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration'. Journal of molecular cell biology. 13:921
Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
Le, T., Zhang, J., Nguyen, A.H., Trigo Torres, R.S., Vo, K., Dutt, N., Lee, J., Ding, Y., Xu, X., Lau, M.P.H., Cao, H. (2021) A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies. Biosensors & bioelectronics. 197:113808
Wang, Y., Lu, X., Wang, X., Qiu, Q., Zhu, P., Ma, L., Ma, X., Herrmann, J., Lin, X., Wang, W., Xu, X. (2021) atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circulation research. 129(8):e166-e182
Ma, X., Xu, X. (2021) A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models. Bio-protocol. 11:e4114
Naderi, A.M., Bu, H., Su, J., Huang, M.H., Vo, K., Trigo Torres, R.S., Chiao, J.C., Lee, J., Lau, M.P.H., Xu, X., Cao, H. (2021) Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos. Computers in Biology and Medicine. 135:104565
Kim, M., Lu, L., Dvornikov, A.V., Ma, X., Ding, Y., Zhu, P., Olson, T.M., Lin, X., Xu, X. (2021) TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy. International Journal of Molecular Sciences. 22(11):
Zhu, P., Qiu, Q., Harris, P.C., Xu, X., Lin, X. (2021) mtor Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish tmem67 Mutants. Journal of the American Society of Nephrology : JASN. 32(4):822-836
Ding, Y., Bu, H., Xu, X. (2020) Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine. Frontiers in Physiology. 11:599244
Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
Yan, J., Li, H., Bu, H., Jiao, K., Zhang, A.X., Le, T., Cao, H., Li, Y., Ding, Y., Xu, X. (2020) Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish. PLoS One. 15:e0232457
Zhang, X., Zhang, A.X., Zhou, B., Xu, X. (2020) A feasibility study for noninvasive measurement of shear wave speed in live zebrafish. Ultrasonics. 107:106170
Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939
Ding, Y., Dvornikov, A.V., Ma, X., Zhang, H., Wang, Y., Lowerison, M., Packard, R.R., Wang, L., Chen, J., Zhang, Y., Hsiai, T., Lin, X., Xu, X. (2019) Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Disease models & mechanisms. 12(10):
Dvornikov, A.V., Wang, M., Yang, J., Zhu, P., Le, T., Lin, X., Cao, H., Xu, X. (2019) Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy. Journal of Molecular and Cellular Cardiology. 133:199-208
Chen, J., Ding, Y., Chen, M., Gau, J., Jen, N., Nahal, C., Tu, S., Chen, C., Zhou, S., Chang, C.C., Lyu, J., Xu, X., Hsiai, T.K., Packard, R.R.S. (2019) Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI insight. 4(8)
Zhang, H., Dvornikov, A.V., Huttner, I.G., Ma, X., Santiago, C.F., Fatkin, D., Xu, X. (2018) A Langendorff-like system to quantify cardiac pump function in adult zebrafish. Disease models & mechanisms. 11(9):
Ma, X., Ding, Y., Wang, Y., Xu, X. (2018) A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish. Journal of visualized experiments : JoVE. (136):
Dvornikov, A.V., de Tombe, P.P., Xu, X. (2018) Phenotyping cardiomyopathy in adult zebrafish. Progress in Biophysics and Molecular Biology. 138:116-125
Lenning, M., Fortunato, J., Le, T., Clark, I., Sherpa, A., Yi, S., Hofsteen, P., Thamilarasu, G., Yang, J., Xu, X., Han, H.D., Hsiai, T.K., Cao, H. (2017) Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection. Sensors (Basel, Switzerland). 18(1)
Packard, R.R.S., Baek, K.I., Beebe, T., Jen, N., Ding, Y., Shi, F., Fei, P., Kang, B.J., Chen, P.H., Gau, J., Chen, M., Tang, J.Y., Shih, Y.H., Ding, Y., Li, D., Xu, X., Hsiai, T.K. (2017) Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Scientific Reports. 7:8603
Long, P.A., Theis, J.L., Shih, Y.H., Maleszewski, J.J., Abell Aleff, P.C., Evans, J.M., Xu, X., Olson, T.M. (2017) Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy. Human molecular genetics. 26(15):2874-2881
Wang, L., Ma, X., Xu, X., Zhang, Y. (2017) Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Scientific Reports. 7:1250
Zhu, P., Sieben, C.J., Xu, X., Harris, P.C., Lin, X. (2017) Autophagy Activators Suppress Cystogenesis in an Autosomal Dominant Polycystic Kidney Disease Model. Human molecular genetics. 26(1):158-172
Shih, Y.H., Dvornikov, A.V., Zhu, P., Ma, X., Kim, M.J., Ding, Y., Xu, X. (2016) Exon- and contraction-dependent functions of titin in sarcomere assembly. Development (Cambridge, England). 143(24):4713-4722
Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
Fei, P., Lee, J., Packard, R.R., Sereti, K.I., Xu, H., Ma, J., Ding, Y., Kang, H., Chen, H., Sung, K., Kulkarni, R., Ardehali, R., Kuo, C.C., Xu, X., Ho, C.M., Hsiai, T.K. (2016) Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Scientific Reports. 6:22489
Yang, J., Shah, S., Olson, T.M., Xu, X. (2016) Modeling GATAD1-Associated Dilated Cardiomyopathy in Adult Zebrafish.. Journal of cardiovascular development and disease. 3(1)
Zhu, P., Xu, X., Lin, X. (2015) Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biology Open. 4(11):1376-86
Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
Sun, Y., Fang, Y., Xu, X., Lu, G., Chen, Z. (2015) Evidence of an Association between Age-Related Functional Modifications and Pathophysiological Changes in Zebrafish Heart. Gerontology. 61(5):435-47
Yang, J., Shih, Y.H., Xu, X. (2014) Understanding cardiac sarcomere assembly with zebrafish genetics. Anatomical record (Hoboken, N.J. : 2007). 297:1681-93
Yang, J., Hartjes, K.A., Nelson, T.J., and Xu, X. (2014) Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis. American journal of physiology. Heart and circulatory physiology. 306(3):H382-H395
Campbell, J.M., Hartjes, K.A., Nelson, T.J., Xu, X., and Ekker, S.C. (2013) New and TALENted Genome Engineering Toolbox. Circulation research. 113(5):571-587
Ding, Y., Liu, W., Deng, Y., Jomok, B., Yang, J., Huang, W., Clark, K.J., Zhong, T., Lin, X., Ekker, S.C., and Xu, X. (2013) Trapping Cardiac Recessive Mutants via Expression-based Insertional Mutagenesis Screening. Circulation research. 112(4):606-617
Yang, J., and Xu, X. (2012) alpha-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4230-4242
Caron, A., Xu, X., and Lin, X. (2012) Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer’s vesicle. Development (Cambridge, England). 139(3):514-24
Kushwaha, S., and Xu, X. (2012) Target of Rapamycin (TOR)-Based Therapy for Cardiomyopathy: Evidence from Zebrafish and Human Studies. Trends in cardiovascular medicine. 22(2):39-43
Ding, Y., Sun, X., Redfield, M., Kushwaha, S., and Xu, X. (2012) Target of rapamcyin (TOR)-based therapeutics for cardiomyopathy: Insights from zebrafish genetics. Cell cycle (Georgetown, Tex.). 11(3):428-429
Yang, J., and Xu, X. (2012) Immunostaining of dissected zebrafish embryonic heart. Journal of visualized experiments : JoVE. (59):e3510
Hoage, T., Ding, Y., and Xu, X. (2012) Quantifying cardiac functions in embryonic and adult zebrafish. Methods in molecular biology (Clifton, N.J.). 843:11-20
Ding, Y., Sun, X., and Xu, X. (2012) TOR-autophagy signaling in adult zebrafish models of cardiomyopathy. Autophagy. 8(1):142-143
Hoage, T., Sun, X., and Xu, X. (2011) Functions of the Wnt/β-catenin pathway in an anemia-induced zebrafish model of cardiomyopathy are location dependent. Biochemical and Biophysical Research Communications. 415(3):490-6
Ding, Y., Sun, X., Huang, W., Hoage, T., Redfield, M., Kushwaha, S., Sivasubbu, S., Lin, X., Ekker, S., and Xu, X. (2011) Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish. Circulation research. 109(6):658-69
Clark, K.J., Balciunas, D., Pogoda, H.M., Ding, Y., Westcot, S.E., Bedell, V.M., Greenwood, T.M., Urban, M.D., Skuster, K.J., Petzold, A.M., Ni, J., Nielsen, A.L., Patowary, A., Scaria, V., Sivasubbu, S., Xu, X., Hammerschmidt, M., and Ekker, S.C. (2011) In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nature Methods. 8(6):506-512
Zhang, R., Yang, J., Zhu, J., and Xu, X. (2009) Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Human molecular genetics. 18(21):4130-4140
Sun, X., Hoage, T., Bai, P., Ding, Y., Chen, Z., Zhang, R., Huang, W., Jahangir, A., Paw, B., Li, Y.G., and Xu, X. (2009) Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One. 4(8):e6596
Huang, W., Zhang, R., and Xu, X. (2009) Myofibrillogenesis in the Developing Zebrafish Heart: A Functional Study of tnnt2. Developmental Biology. 331(2):237-249
Zhang, R., and Xu, X. (2009) Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: An inhibitory mechanism of ventricle-specific gene expression. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(6):1564-1573
Lin, X., and Xu, X. (2009) Distinct functions of Wnt/{beta}-catenin signaling in KV development and cardiac asymmetry. Development (Cambridge, England). 136(2):207-217
Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M.J., and Xu, X. (2008) Depletion of Zebrafish Essential and Regulatory Myosin Light Chains Reduces Cardiac Function Through Distinct Mechanisms. Cardiovascular research. 79(1):97-108
Sun, X., Zhang, R., Lin, X., and Xu, X. (2008) Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-Rich Intestinal Protein 2 in Rhombomere 6. Circulation research. 102(7):831-839
Wang, L., Dutta, S.K., Kojima, T., Xu, X., Khosravi-Far, R., Ekker, S.C., and Mukhopadhyay, D. (2007) Neuropilin-1 Modulates p53/Caspases Axis to Promote Endothelial Cell Survival. PLoS One. 2(11):e1161
Lin, X., Rinaldo, L., Fazly, A.F., and Xu, X. (2007) Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Developmental Biology. 303(2):536-548
Rich, A., Leddon, S.A., Hess, S.L., Gibbons, S.J., Miller, S., Xu, X., and Farrugia, G. (2007) Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(3):903-911
Seeley, M., Huang, W., Chen, Z., Wolff, W.O., Lin, X., and Xu, X. (2007) Depletion of Zebrafish Titin Reduces Cardiac Contractility by Disrupting the Assembly of Z-Discs and A-Bands. Circulation research. 100(2):238-245
Wang, L., Mukhopadhyay, D., and Xu, X. (2006) C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(9):1513-1515
Xu, X., Meiler, S.E., Zhong, T.P., Mohideen, M., Crossley, D.A., Burggren, W.W., and Fishman, M.C. (2002) Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nature Genetics. 30(2):205-209