ZFIN ID: ZDB-PERS-000330-13
Xiong, Jing-Wei
Email: jingwei_xiong@pku.edu.cn
URL: http://www.imm.pku.edu.cn
Affiliation: Jing-Wei Xiong Lab
Address: Laboratory of Cardiovascular Development Institute of Molecular Medicine Peking University New Life Science Research Building Room 102 Mail Box 140 Beijing 100871 China
Country: China
Phone: 010-6276-6239
ORCID ID: 0000-0001-8438-4782

Professor, Developmental Biology
Peking University, Beijing, China

Research Interests: Cardiovascular development and regeneration

Zhang, Z., Chen, Y., Zheng, L., Du, J., Wei, S., Zhu, X., Xiong, J.W. (2023) A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction. Disease models & mechanisms. 16(5):
Zhou, X., Zhang, C., Wu, X., Hu, X., Zhang, Y., Wang, X., Zheng, L., Gao, P., Du, J., Zheng, W., Shang, H., Hu, K., Jiang, Z., Nie, Y., Hu, S., Xiao, R.P., Zhu, X., Xiong, J.W. (2022) Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Nature communications. 13:6672
Du, J., Zheng, L., Gao, P., Yang, H., Yang, W.J., Guo, F., Liang, R., Feng, M., Wang, Z., Zhang, Z., Bai, L., Bu, Y., Xing, S., Zheng, W., Wang, X., Quan, L., Hu, X., Wu, H., Chen, Z., Chen, L., Wei, K., Zhang, Z., Zhu, X., Zhang, X., Tu, Q., Zhao, S.M., Lei, X., Xiong, J.W. (2022) A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell. 29:545-558.e13
Zhou, Q., Lei, L., Zhang, H., Chiu, S.C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., Xiong, J.W. (2021) Proprotein Convertase Furina Is Required for Heart Development in Zebrafish. Journal of Cell Science. 134(21):
Wang, F., Hou, W., Xiao, C., Hao, Y., Su, N., Deng, Y., Wang, J., Yu, L., Xie, J.M., Xiong, J.W., Luo, Y. (2021) Endothelial cell membrane-based biosurface for targeted delivery to acute injury: analysis of leukocyte-mediated nanoparticle transportation. Nanoscale. 13:14636-14643
Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Corrigendum: Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:699796
Zheng, L., Du, J., Wang, Z., Zhou, Q., Zhu, X., Xiong, J.W. (2021) Molecular regulation of myocardial proliferation and regeneration. Cell regeneration (London, England). 10:13
Xiong, J.W. (2020) Evolutionary insights into heart regeneration. Cell regeneration (London, England). 9:23
Pang, M., Bai, L., Zong, W., Wang, X., Bu, Y., Xiong, C., Zheng, J., Li, J., Gao, W., Feng, Z., Chen, L., Zhang, J., Cheng, H., Zhu, X., Xiong, J.W. (2020) Light-sheet fluorescence imaging charts the gastrula origin of vascular endothelial cells in early zebrafish embryos. Cell discovery. 6:74
Pang, M., Xiong, C., Xiao, C., Du, J., Zheng, L., Bai, L., Zhu, X., Xiong, J.W. (2020) Critical role of zebrafish dnajb5 in myocardial proliferation and regeneration. Journal of genetics and genomics = Yi chuan xue bao. 47(8):493-496
Ye, S., Zhao, T., Zhang, W., Tang, Z., Gao, C., Ma, Z., Xiong, J.W., Peng, J., Tan, W.Q., Chen, J. (2020) p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death & Disease. 11:568
Wang, F., Wang, X., Gao, L., Meng, L.Y., Xie, J.M., Xiong, J.W., Luo, Y. (2019) Nanoparticle-mediated delivery of siRNA into zebrafish heart: a cell-level investigation on the biodistribution and gene silencing effects. Nanoscale. 11(39):18052-18064
Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L. (2019) Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nature cell biology. 21:966-977
Zhao, J., Zong, W., Zhao, Y., Gou, D., Liang, S., Shen, J., Wu, Y., Zheng, X., Wu, R., Wang, X., Niu, F., Wang, A., Zhang, Y., Xiong, J.W., Chen, L., Liu, Y. (2019) In Vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development. eLIFE. 8:
Zhu, X., Xiao, C., Xiong, J.W. (2018) Epigenetic Regulation of Organ Regeneration in Zebrafish. Journal of cardiovascular development and disease. 5(4)
Ma, Z., Zhu, P., Pang, M., Guo, L., Chang, N., Zheng, J., Zhu, X., Gao, C., Huang, H., Cui, Z., Xiong, J.W., Peng, J., Chen, J. (2017) A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Scientific Reports. 7:10381
Lei, L., Yan, S.Y., Yang, R., Chen, J.Y., Li, Y., Bu, Y., Chang, N., Zhou, Q., Zhu, X., Li, C.Y., Xiong, J.W. (2017) Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors. Nucleic acids research. 45(6):3422-3436
Yang, R., Zhang, Y., Huang, D., Luo, X., Zhang, L., Zhu, X., Zhang, X., Liu, Z., Han, J., Xiong, J.W. (2017) Miconazole protects blood vessels from matrix metalloproteinase 9-dependent rupture and hemorrhage. Disease models & mechanisms. 10(3):337-348
Wang, F., Gao, L., Meng, L.Y., Xie, J.M., Xiong, J.W., and Luo, Y. (2016) A Neutralized Noncharged Polyethylenimine-Based System for Efficient Delivery of siRNA into Heart without Toxicity. ACS applied materials & interfaces. 8(49):33529-33538
Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., Peng, J., Tang, F., Zhu, X., Xiong, J.W. (2016) Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature communications. 7:13787
Cheng, F., Miao, L., Wu, Q., Gong, X., Xiong, J., Zhang, J. (2016) Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish. Development (Cambridge, England). 143(19):3522-3531
Wu, Q., Zhang, J., Koh, W., Yu, Q., Zhu, X., Amsterdam, A., Davis, G.E., Arnaout, M.A., Xiong, J.W. (2015) Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12):4989-5005
Diao, J., Wang, H., Chang, N., Zhou, X.H., Zhu, X., Wang, J., Xiong, J.W. (2015) PEG-PLA Nanoparticles facilitate siRNA knockdown in adult zebrafish heart. Developmental Biology. 406(2):196-202
Zhang, M., Sun, T., Jian, C., Lei, L., Han, P., Lv, Q., Yang, R., Zhou, X., Xu, J., Hu, Y., Men, Y., Huang, Y., Zhang, C., Zhu, X., Wang, X., Cheng, H., Xiong, J.W. (2015) Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLoS One. 10:e0132567
Gao, H., Bu, Y., Wu, Q., Wang, X., Chang, N., Lei, L., Chen, S., Liu, D., Zhu, X., Hu, K., Xiong, J.W. (2015) Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish. Journal of Cell Science. 128(12):2340-50
Yang, R., Yan, S., Zhu, X., Li, C.Y., Liu, Z., Xiong, J.W. (2015) Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish. Experimental hematology. 43(4):331-341.e8
Han, P., Zhou, X.H., Chang, N., Xiao, C.L., Yan, S., Ren, H., Yang, X.Z., Zhang, M.L., Wu, Q., Tang, B., Diao, J.P., Zhu, X., Zhang, C., Li, C.Y., Cheng, H., Xiong, J.W. (2014) Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research. 24(9):1091-107
Bu, Y., Su, F., Wang, X., Gao, H., Lei, L., Chang, N., Wu, Q., Hu, K., Zhu, X., Chang, Z., Meng, K., Xiong, J.W. (2014) Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. Journal of Cell Science. 127(Pt 12):2761-70
Yan, B., Han, P., Pan, L., Lu, W., Xiong, J., Zhang, M., Zhang, W., Li, L., Wen, Z. (2014) Il-1beta and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury-Induced Inflammation Model. Journal of immunology (Baltimore, Md. : 1950). 192(12):5998-6008
Zhu, Z., Chen, J., Xiong, J.W., Peng, J. (2014) Haploinsufficiency of Def Activates p53-Dependent TGFbeta Signalling and Causes Scar Formation after Partial Hepatectomy. PLoS One. 9:e96576
Xiong, J.W., and Chang N.N. (2013) Recent advances in heart regeneration. Birth defects research. Part C, Embryo today : reviews. 99(3):160-169
Chang, N., Sun, C., Gao, L., Zhu, D., Xu, X., Zhu, X., Xiong, J.W., and Xi, J.J. (2013) Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos. Cell Research. 23(4):465-472
Wang, X., Yu, Q., Wu, Q., Bu, Y., Changm, N.N., Yan, S., Zhou, X.H., Zhu, X., and Xiong, J.W. (2013) Genetic Interaction between pku300 and fbn2b Controls Endocardial Cell Proliferation and Valve Development in Zebrafish. Journal of Cell Science. 126(Pt 6):1381-91
Zhen, Y.S., Wu, Q., Xiao, C.L., Chang, N.N., Wang, X., Lei, L., Zhu, X., and Xiong, J.W. (2012) Overlapping cardiac programs in heart development and regeneration. Journal of genetics and genomics = Yi chuan xue bao. 39(9):443-449
Fei, P., Yu, Z., Wang, X., Lu, P.J., Fu, Y., He, Z., Xiong, J., and Huang, Y. (2012) High dynamic range optical projection tomography (HDR-OPT). Optics express. 20(8):8824-8836
Wang, W., Ni, L., Yu, Q., Xiong, J., Liu, H.C., and Rosenwaks, Z. (2010) Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1827-1837
Xiong, J.W., Yu, Q., Zhang, J., and Mably, J.D. (2008) An Acyltransferase Controls the Generation of Hematopoietic and Endothelial Lineages in Zebrafish. Circulation research. 102(9):1057-1064
Xiong, J.W. (2008) Molecular and developmental biology of the hemangioblast. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(5):1218-1231
Wang, C., Faloon, P.W., Tan, Z., Lv, Y., Zhang, P., Ge, Y., Deng, H., and Xiong, J.W. (2007) Mouse lycat controls the development of hematopoietic and endothelial lineages during in vitro ES cell differentiation. Blood. 110(10):3601-3609
Moser, M., Yu, Q., Bode, C., Xiong, J.W., and Patterson, C. (2007) BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish. Journal of Molecular and Cellular Cardiology. 43(3):243-253
Li, X., Xiong, J.W., Shelley, C.S., Park, H., and Arnaout, M.A. (2006) The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development (Cambridge, England). 133(18):3641-3650

1. Xiong JW, Battaglino B, Leahy A, and Stuhlmann H. (1998). Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Developmental Dynamics, 212: 181-197.
2. Xiong JW, Leahy A, Lee HH, and Stuhlmann H. (1999). Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors. Developmental Biology, 206: 123-141.
3. Xiong JW, Leahy A, and Stuhlmann H. (1999). Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development. Mechanism of Development, 86: 183-191.
4. Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Gardner H, and Stuhlmann H. (2005). Dosage-dependent requirement for mouse Vezf1 in vascular system development. Developmental Biology, 283: 140-156.
5. Wang C, Faloon PW, Tan Z, Lv Z, Zhang P, Ge Y, *Deng H, and *Xiong JW. (2007). Mouse Lycat controls the development of hematopoietic and endothelial lineages during in vitro ES cell differentiation. Blood, 110: 3601-3609.
6. Xiong JW. (2008). Molecular and developmental biology of the hemangioblast. Developmental Dynamics, 237(5):1218-1231.
7. *Hu XL, Chang N, Wang X, Zhou F, Zhou X, Zhu X and *Xiong JW (2013). Heritable gene targeting with gRNA/Cas9 in rats. Cell Research, 23: 1322-1325.