ZFIN Morpholino: MO1-nphp4

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-nphp4

Expressed Gene	Anatomy	Figures
spaw	lateral mesoderm	Fig. S2 from Burcklé et al., 2011

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Phenotype

Phenotype resulting from MO1-nphp4

Phenotype	Fish	Figures
brain hydrophilic, abnormal	WT + MO1-nphp4 + MO4-tp53	Fig. 2 from Slanchev et al., 2011
cloaca dilated, abnormal	hsc5Tg + MO1-nphp4	Fig. S12 from Garcia et al., 2022
cloaca development disrupted, abnormal	WT + MO1-nphp4	Fig. 3 from Burcklé et al., 2011
cloacal chamber cystic, abnormal	WT + MO1-nphp4	Fig. 3 from Burcklé et al., 2011
cloacal chamber deformed, abnormal	zf106Tg + MO1-nphp4	Fig. 3, Fig. 7 from Burcklé et al., 2011

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Phenotype of all Fish created by or utilizing MO1-nphp4

Phenotype	Fish	Conditions	Figures
pronephric duct cilium decreased length, abnormal	WT + MO1-nphp4	standard conditions	Fig. 2 from Burcklé et al., 2011
cloacal chamber cilium decreased length, abnormal	WT + MO1-nphp4	standard conditions	Fig. 2 from Burcklé et al., 2011
cloaca development disrupted, abnormal	WT + MO1-nphp4	standard conditions	Fig. 3 from Burcklé et al., 2011
cloacal chamber dilated, abnormal	WT + MO1-nphp4	standard conditions	Fig. 3 from Burcklé et al., 2011
convergent extension involved in gastrulation process quality, abnormal	WT + MO1-nphp4	standard conditions	Fig. 4 from Burcklé et al., 2011

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Citations

Include unpublished citations

Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
Epting, D., Decker, E., Ott, E., Eisenberger, T., Bader, I., Bachmann, N., Bergmann, C. (2022) The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Human molecular genetics. 31(14):2295-2306
Garcia, H., Serafin, A.S., Silbermann, F., Porée, E., Viau, A., Mahaut, C., Billot, K., Birgy, É., Garfa-Traore, M., Roy, S., Ceccarelli, S., Mehraz, M., Rodriguez, P.C., Deleglise, B., Furio, L., Jabot-Hanin, F., Cagnard, N., Del Nery, E., Fila, M., Sin-Monnot, S., Antignac, C., Lyonnet, S., Krug, P., Salomon, R., Annereau, J.P., Benmerah, A., Delous, M., Briseño-Roa, L., Saunier, S. (2022) Agonists of prostaglandin E₂ receptors as potential first in class treatment for nephronophthisis and related ciliopathies. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115960119
Kayser, N., Zaiser, F., Veenstra, A.C., Wang, H., Göcmen, B., Eckert, P., Franz, H., Köttgen, A., Walz, G., Yakulov, T.A. (2022) Clock genes rescue nphp mutations in zebrafish. Human molecular genetics. 31(24):4143-4158
Borgal, L., Habbig, S., Hatzold, J., Liebau, M.C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T., and Schermer, B. (2012) The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt-Regulator Jade-1 to the Nucleus to Negatively Regulate Beta-Catenin Signaling. The Journal of biological chemistry. 287(30):25370-25380
Burcklé, C., Gaudé, H.M., Vesque, C., Silbermann, F., Salomon, R., Jeanpierre, C., Antignac, C., Saunier, S., and Schneider-Maunoury, S. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Human molecular genetics. 20(13):2611-27
Slanchev, K., Pütz, M., Schmitt, A., Kramer-Zucker, A., and Walz, G. (2011) Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Human molecular genetics. 20(16):3119-28

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