ZFIN Morpholino: MO2-esr1

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-esr1

Expressed Gene	Anatomy	Figures
comtb	whole organism	Fig. 7 from Bertotto et al., 2018
drd1b	whole organism	Fig. 6 from Bertotto et al., 2018
mao	whole organism	Fig. 7 from Bertotto et al., 2018
runx1	ventral wall of dorsal aorta	Fig. 2 from Carroll et al., 2014
vtg1	whole organism	Fig. 5 from Bertotto et al., 2018

Phenotype

Phenotype resulting from MO2-esr1

Phenotype	Fish	Figures
whole organism mao expression decreased amount, abnormal	SPF 5-D + MO2-esr1	Fig. 7 from Bertotto et al., 2018
whole organism vtg1 expression decreased amount, abnormal	SPF 5-D + MO2-esr1	Fig. 5 from Bertotto et al., 2018
whole organism comtb expression decreased amount, abnormal	SPF 5-D + MO2-esr1	Fig. 7 from Bertotto et al., 2018
whole organism drd1b expression decreased amount, abnormal	SPF 5-D + MO2-esr1	Fig. 6 from Bertotto et al., 2018

Phenotype of all Fish created by or utilizing MO2-esr1

Phenotype	Fish	Conditions	Figures
whole organism vtg1 expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: 17alpha-ethynylestradiol	Fig. 5 from Bertotto et al., 2018
whole organism drd1b expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: 17alpha-ethynylestradiol	Fig. 6 from Bertotto et al., 2018
whole organism mao expression decreased amount, abnormal	SPF 5-D + MO2-esr1	control	Fig. 7 from Bertotto et al., 2018
whole organism comtb expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: 17alpha-ethynylestradiol	Fig. 7 from Bertotto et al., 2018
whole organism vtg1 expression decreased amount, abnormal	SPF 5-D + MO2-esr1	control	Fig. 5 from Bertotto et al., 2018
whole organism drd1b expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: bifenthrin	Fig. 6 from Bertotto et al., 2018
whole organism comtb expression decreased amount, abnormal	SPF 5-D + MO2-esr1	control	Fig. 7 from Bertotto et al., 2018
whole organism vtg1 expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: bifenthrin	Fig. 5 from Bertotto et al., 2018
whole organism drd1b expression decreased amount, abnormal	SPF 5-D + MO2-esr1	control	Fig. 6 from Bertotto et al., 2018
whole organism mao expression decreased amount, abnormal	SPF 5-D + MO2-esr1	chemical treatment by environment: 17alpha-ethynylestradiol	Fig. 7 from Bertotto et al., 2018
ventral wall of dorsal aorta runx1 expression decreased amount, abnormal	WT + MO2-esr1	chemical treatment by environment: 17beta-estradiol	Fig. 2 from Carroll et al., 2014

Citations

Include unpublished citations

Chaturantabut, S., Shwartz, A., Garnaas, M.K., LaBella, K., Li, C.C., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W. (2020) Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development. Hepatology (Baltimore, Md.). 72(5):1786-1799
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Bertotto, L.B., Dasgupta, S., Vliet, S., Dudley, S., Gan, J., Volz, D.C., Schlenk, D. (2018) Evaluation of the estrogen receptor alpha as a possible target of bifenthrin effects in the estrogenic and dopaminergic signaling pathways in zebrafish embryos. The Science of the total environment. 651:2424-2431
Moreman, J., Takesono, A., Trznadel, M., Winter, M., Perry, A., Wood, M., Rogers, N.J., Kudoh, T., Tyler, C.R. (2018) Estrogenic mechanisms and cardiac responses following early life exposure to Bisphenol A (BPA) and its metabolite 4-methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in zebrafish. Environmental science & technology. 52(11):6656-6665
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Pang, Y., and Thomas, P. (2010) Role of G protein-coupled estrogen receptor 1, GPER, in inhibition of oocyte maturation by endogenous estrogens in zebrafish. Developmental Biology. 342(2):194-206

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